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Image-Guided Focused Ultrasound for the Treatment of Bone Metastases: Current Status and Future Direction

Image-Guided Focused Ultrasound for the Treatment of Bone Metastases: Current Status and Future... Bone metastases are a pervasive problem in oncology. For many of these patients, pain due to osseous metastases is the predominant factor negatively influencing quality of life. High-intensity focused ultrasound (FUS) therapy is a novel technology used for the treatment of bone metastases. FUS can be done with either ultrasound or magnetic resonance guidance (USgFUS or MRgFUS respectively). We review the outcomes and toxicity of current studies using USgFUS and MRgFUS for the treatment of bone metastases. A recently completed phase III trial has confirmed statistically and clinically significant benefit in pain control and quality of life for patients with painful bone metastases who were not candidates for radiation therapy. Future areas of research include expansion of sites suitable for MRgFUS treatment, applicability of MRgFUS as a primary treatment for painful bone metastases either as standalone therapy or in combination with radiation, and development of conformal treatment devices. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Radiology Reports Springer Journals

Image-Guided Focused Ultrasound for the Treatment of Bone Metastases: Current Status and Future Direction

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References (35)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Imaging / Radiology
eISSN
2167-4825
DOI
10.1007/s40134-013-0012-1
Publisher site
See Article on Publisher Site

Abstract

Bone metastases are a pervasive problem in oncology. For many of these patients, pain due to osseous metastases is the predominant factor negatively influencing quality of life. High-intensity focused ultrasound (FUS) therapy is a novel technology used for the treatment of bone metastases. FUS can be done with either ultrasound or magnetic resonance guidance (USgFUS or MRgFUS respectively). We review the outcomes and toxicity of current studies using USgFUS and MRgFUS for the treatment of bone metastases. A recently completed phase III trial has confirmed statistically and clinically significant benefit in pain control and quality of life for patients with painful bone metastases who were not candidates for radiation therapy. Future areas of research include expansion of sites suitable for MRgFUS treatment, applicability of MRgFUS as a primary treatment for painful bone metastases either as standalone therapy or in combination with radiation, and development of conformal treatment devices.

Journal

Current Radiology ReportsSpringer Journals

Published: May 5, 2013

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