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IgE Test in Secretions of Patients with Respiratory Allergy

IgE Test in Secretions of Patients with Respiratory Allergy Purpose of Review IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP). Recent Findings Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Also, mucosal synthesis of IgE can occur in the absence of systemic atopy, and may be relevant in atopic and non- atopic phenotypes of rhinitis as demonstrated in LAR. Specific IgE (sIgE) detection varies depending on technique used for sample collection and its measurement. sIgE detection is highly specific for diagnosis of LAR. Moreover, measurement of sIgE in secretions could be useful in monitoring response to allergen-specific immunotherapy in both AR and LAR phenotypes. Summary This review will focus on recent developments in the role of IgE in respiratory diseases, and the clinical implications of its measurement in secretions. . . . . Keywords Allergic IgE Local allergic rhinitis Rhinitis Allergen-specific immunotherapy Introduction not always correlate with clinical allergy and does not give in- formation about the status of local IgE in the target organ [2, 3]. Immunoglobulin E (IgE) is the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

IgE Test in Secretions of Patients with Respiratory Allergy

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References (97)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Allergology
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-018-0821-7
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP). Recent Findings Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Also, mucosal synthesis of IgE can occur in the absence of systemic atopy, and may be relevant in atopic and non- atopic phenotypes of rhinitis as demonstrated in LAR. Specific IgE (sIgE) detection varies depending on technique used for sample collection and its measurement. sIgE detection is highly specific for diagnosis of LAR. Moreover, measurement of sIgE in secretions could be useful in monitoring response to allergen-specific immunotherapy in both AR and LAR phenotypes. Summary This review will focus on recent developments in the role of IgE in respiratory diseases, and the clinical implications of its measurement in secretions. . . . . Keywords Allergic IgE Local allergic rhinitis Rhinitis Allergen-specific immunotherapy Introduction not always correlate with clinical allergy and does not give in- formation about the status of local IgE in the target organ [2, 3]. Immunoglobulin E (IgE) is the

Journal

Current Allergy and Asthma Reports – Springer Journals

Published: Oct 13, 2018

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