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Identifying t-cell epitopes of the VP1 capsid protein of human rhinovirus

Identifying t-cell epitopes of the VP1 capsid protein of human rhinovirus Gaido et al. World Allergy Organization Journal 2015, 8(Suppl 1):A64 http://www.waojournal.org/content/8/S1/A64 MEETING ABSTRACT Open Access Identifying t-cell epitopes of the VP1 capsid protein of human rhinovirus 1* 1 1 2 Cibele Marina Gaido , Belinda J Hales , Peter Le Souëf , Peter Le Souëf From 3rd WAO International Scientific Conference (WISC) 2014 Rio de Janeiro, Brazil. 6-9 December 2014 Background Four pairs of cross-reactive peptides were identified for The newly identified HRV-C has been linked to more HRV-A and HRV-C that stimulated the cells of more severe symptoms of asthma and an increased risk of than 40% of the subjects tested. prior and subsequent hospital admission. Our research team has recently reported that despite their sequence Conclusions dissimilarity, the HRV-A and HRV-C species have a high To our knowledge, this is the first study to map T-cell epi- degree of antibody cross-reactivity and the HRV-C speci- topes in a genotype of HRV-C and also the first to map fic antibody response is low (Iwasaki et al., 2013). This the entire HRV VP1 protein. Future HLA typing and in study aims to identify species-specific and cross-reactive silico studies for other HRV-A and HRV-C genotypes T-cell epitopes for the HRV-A http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Allergy Organization Journal Springer Journals

Identifying t-cell epitopes of the VP1 capsid protein of human rhinovirus

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Identifying t-cell epitopes of the VP1 capsid protein of human rhinovirus

Abstract

Gaido et al. World Allergy Organization Journal 2015, 8(Suppl 1):A64 http://www.waojournal.org/content/8/S1/A64 MEETING ABSTRACT Open Access Identifying t-cell epitopes of the VP1 capsid protein of human rhinovirus 1* 1 1 2 Cibele Marina Gaido , Belinda J Hales , Peter Le Souëf , Peter Le Souëf From 3rd WAO International Scientific Conference (WISC) 2014 Rio de Janeiro, Brazil. 6-9 December 2014 Background Four pairs of cross-reactive peptides were identified for The newly...
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Publisher
Springer Journals
Copyright
Copyright © 2015 by Gaido et al; licensee BioMed Central Ltd.
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
1939-4551
DOI
10.1186/1939-4551-8-S1-A64
Publisher site
See Article on Publisher Site

Abstract

Gaido et al. World Allergy Organization Journal 2015, 8(Suppl 1):A64 http://www.waojournal.org/content/8/S1/A64 MEETING ABSTRACT Open Access Identifying t-cell epitopes of the VP1 capsid protein of human rhinovirus 1* 1 1 2 Cibele Marina Gaido , Belinda J Hales , Peter Le Souëf , Peter Le Souëf From 3rd WAO International Scientific Conference (WISC) 2014 Rio de Janeiro, Brazil. 6-9 December 2014 Background Four pairs of cross-reactive peptides were identified for The newly identified HRV-C has been linked to more HRV-A and HRV-C that stimulated the cells of more severe symptoms of asthma and an increased risk of than 40% of the subjects tested. prior and subsequent hospital admission. Our research team has recently reported that despite their sequence Conclusions dissimilarity, the HRV-A and HRV-C species have a high To our knowledge, this is the first study to map T-cell epi- degree of antibody cross-reactivity and the HRV-C speci- topes in a genotype of HRV-C and also the first to map fic antibody response is low (Iwasaki et al., 2013). This the entire HRV VP1 protein. Future HLA typing and in study aims to identify species-specific and cross-reactive silico studies for other HRV-A and HRV-C genotypes T-cell epitopes for the HRV-A

Journal

World Allergy Organization Journal – Springer Journals

Published: Apr 8, 2015

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