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G. Seki, E. Frömter (1992)
Acetazolamide inhibition of basolateral base exit in rabbit renal proximal tubule S2 segmentPflügers Archiv, 422
C. Faisy, F. Meziani, B. Planquette, M. Clavel, A. Gacouin, C. Bornstain, F. Schneider, A. Duguet, S. Gibot, N. Lerolle, J. Ricard, O. Sanchez, M. Djibré, J. Ricome, A. Rabbat, N. Heming, S. Urien, M. Esvan, S. Katsahian (2016)
Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.JAMA, 315 5
N. Yunos, R. Bellomo, D. Story, J. Kellum (2010)
Bench-to-bedside review: Chloride in critical illnessCritical Care, 14
(US National Institutes of Health. ClinicalTrials.gov Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure. https://clinicaltrials.gov/ct2/show/NCT03446651?term=chloride&cond=Heart+Failure&draw=2&rank=2. Accessed 09 June 2020.)
US National Institutes of Health. ClinicalTrials.gov Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure. https://clinicaltrials.gov/ct2/show/NCT03446651?term=chloride&cond=Heart+Failure&draw=2&rank=2. Accessed 09 June 2020.US National Institutes of Health. ClinicalTrials.gov Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure. https://clinicaltrials.gov/ct2/show/NCT03446651?term=chloride&cond=Heart+Failure&draw=2&rank=2. Accessed 09 June 2020., US National Institutes of Health. ClinicalTrials.gov Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure. https://clinicaltrials.gov/ct2/show/NCT03446651?term=chloride&cond=Heart+Failure&draw=2&rank=2. Accessed 09 June 2020.
(2010)
Acid–base transport by the renal proximal tubuleJ Nephrol., 23
A. Maciel (2009)
Severe metabolic alkalosis due to the combination of unmeasured cations and hypochloraemia in a patient with gastroparesia and frequent emesisBMJ Case Reports, 2009
Chao‐ling Yang, Xiaoman Zhu, D. Ellison (2007)
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.The Journal of clinical investigation, 117 11
A. Peixoto, R. Alpern (2013)
Treatment of severe metabolic alkalosis in a patient with congestive heart failure.American journal of kidney diseases : the official journal of the National Kidney Foundation, 61 5
H. Clemo, Joseph Feher, C. Baumgarten (1992)
Modulation of rabbit ventricular cell volume and Na+/K+/2Cl- cotransport by cGMP and atrial natriuretic factorThe Journal of General Physiology, 100
M. Griffin, Aaron Soufer, Erden Goljo, Matthew Colna, V. Rao, S. Jeon, P. Raghavendra, Julie D’Ambrosi, R. Riello, S. Coca, Devin Mahoney, D. Jacoby, T. Ahmad, Michael Chen, W. Tang, Jeffrey Turner, W. Mullens, F. Wilson, J. Testani (2020)
Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center's Experience.JACC. Heart failure
G. Ackerman (1976)
Metabolic alkalosis.The Journal of the Arkansas Medical Society, 73 2
Richa Gupta, J. Testani, S. Collins (2019)
Diuretic Resistance in Heart FailureCurrent heart failure reports, 16
F. Verbrugge, P. Martens, K. Ameloot, Veerle Haemels, J. Penders, M. Dupont, W. Tang, W. Droogné, W. Mullens (2019)
Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistanceEuropean Journal of Heart Failure, 21
D. Levine, D. Vandorpe, M. Iacovitti (1990)
Luminal chloride modulates rat distal tubule bidirectional bicarbonate flux in vivo.The Journal of clinical investigation, 85 6
C. Flear, P. Hilton (1979)
Hyponatraemia and severity and outcome of myocardial infarction.British Medical Journal, 1
G. Felker, L. Allen, S. Pocock, L. Shaw, J. McMurray, M. Pfeffer, K. Swedberg, Duolao Wang, S. Yusuf, E. Michelson, C. Granger (2007)
Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank.Journal of the American College of Cardiology, 50 1
(2006)
Metabolic alkalosisJ Nephrol., 19
J. Grodin, F. Verbrugge, Stephen Ellis, W. Mullens, J. Testani, W. Tang (2016)
Importance of Abnormal Chloride Homeostasis in Stable Chronic Heart FailureCirculation: Heart Failure, 9
H. Kataoka (2019)
Acetazolamide as a potent chloride-regaining diuretic: short- and long-term effects, and its pharmacologic role under the ‘chloride theory’ for heart failure pathophysiologyHeart and Vessels
F. Verbrugge, P. Steels, L. Grieten, P. Nijst, W. Tang, W. Mullens (2015)
Hyponatremia in acute decompensated heart failure: depletion versus dilution.Journal of the American College of Cardiology, 65 5
K. Bomsztyk (1986)
Chloride transport by rat renal proximal tubule: effects of bicarbonate absorption.The American journal of physiology, 250 6 Pt 2
J. Grodin, Jie-Lena Sun, K. Anstrom, Horng Chen, R. Starling, J. Testani, W. Tang (2017)
Implications of Serum Chloride Homeostasis in Acute Heart Failure (from ROSE-AHF).The American journal of cardiology, 119 1
O. Hutter, D. Noble (1961)
Anion conductance of cardiac muscleThe Journal of Physiology, 157
K. Kahle, J. Rinehart, R. Lifton (2010)
Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.Biochimica et biophysica acta, 1802 12
Sylvie Breton (2001)
The cellular physiology of carbonic anhydrases.JOP : Journal of the pancreas, 2 4 Suppl
Y. Chan (1980)
Adrenergic control of bicarbonate absorption in the proximal convoluted tubule of the rat kidneyPflügers Archiv, 388
BY Carmeliet (1961)
Chloride ions and the membrane potential of Purkinje fibresThe Journal of Physiology, 156
Y. Wakabayashi, T. Mishina, F. Marumo, R. Kikawada (1986)
Two cases of saline-responsive metabolic alkalosis associated with high urinary chloride concentrations.The Tohoku journal of experimental medicine, 150 4
José Ponce‐Coria, Pedro San-Cristobal, K. Kahle, N. Vázquez, Diana Pacheco‐Alvarez, P. Heros, Patricia Juárez, E. Muñoz, G. Michel, N. Bobadilla, I. Giménez, R. Lifton, S. Hebert, G. Gamba (2008)
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinasesProceedings of the National Academy of Sciences, 105
J. Ferreira, N. Girerd, K. Duarte, S. Coiro, J. McMurray, H. Dargie, B. Pitt, K. Dickstein, J. Testani, F. Zannad, P. Rossignol (2017)
Serum Chloride and Sodium Interplay in Patients With Acute Myocardial Infarction and Heart Failure With Reduced Ejection Fraction: An Analysis From the High-Risk Myocardial Infarction Database InitiativeCirculation: Heart Failure, 10
Silvana Bazúa-Valenti, María Chávez-Canales, Lorena Rojas‐vega, Xochiquetzal González-Rodríguez, N. Vázquez, Alejandro Rodríguez-Gama, Eduardo Argaiz, Zesergio Melo, C. Plata, D. Ellison, J. García-Valdés, J. Hadchouel, G. Gamba (2015)
The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride.Journal of the American Society of Nephrology : JASN, 26 8
M. Khan (1980)
Treatment of refractory congestive heart failure and normokalemic hypochloremic alkalosis with acetazolamide and spironolactone.Canadian Medical Association journal, 123 9
A. Terker, María Castañeda-Bueno, Mohammed Ferdaus, Ryan Cornelius, Kayla Erspamer, X. Su, Lauren Miller, J. McCormick, Wen‐Hui Wang, G. Gamba, Chao‐ling Yang, D. Ellison (2018)
With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo.American journal of physiology. Renal physiology, 315 4
J. Pichake, P. Kharkar, M. Ceruso, C. Supuran, M. Toraskar (2014)
Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives.ACS medicinal chemistry letters, 5 7
G. Planelles (2004)
Chloride transport in the renal proximal tubulePflügers Archiv, 448
W. Mullens, F. Verbrugge, P. Nijst, P. Martens, Katrien Tartaglia, E. Theunissen, L. Bruckers, W. Droogné, P. Troisfontaines, K. Damman, Johan Lassus, A. Mebazaa, G. Filippatos, F. Ruschitzka, M. Dupont (2018)
Rationale and design of the ADVOR (Acetazolamide in Decompensated Heart Failure with Volume Overload) trialEuropean Journal of Heart Failure, 20
A. Terker, Chong Zhang, Kayla Erspamer, G. Gamba, Chao‐ling Yang, D. Ellison (2015)
Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasisKidney international, 89
F. Zannad (1995)
Aldosterone and heart failure.European heart journal, 16 Suppl N
Paul Jones, Michael Greenstone (2001)
Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease.The Cochrane database of systematic reviews, 1
(2020)
of Health
D. Dobyan, R. Bulger (1982)
Renal carbonic anhydrase.The American journal of physiology, 243 4
Fu-Ying, Liu, Martin, G. Cogan (1988)
Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule. Modes of action, mechanism, and kinetics.The Journal of clinical investigation, 82 2
G. Williams (2005)
Aldosterone and Heart Failure: The Rest of the StoryHeart Failure Reviews, 10
R. Vaughan-Jones, K. Spitzer, P. Swietach (2009)
Intracellular pH regulation in heart.Journal of molecular and cellular cardiology, 46 3
J. Lorenz, H. Weihprecht, J. Schnermann, O. Skøtt, J. Briggs (1991)
Renin release from isolated juxtaglomerular apparatus depends on macula densa chloride transport.The American journal of physiology, 260 4 Pt 2
C. Orchard, H. Cingolani (1994)
Acidosis and arrhythmias in cardiac muscle.Cardiovascular research, 28 9
S. Eiam-Ong, N. Kurtzman, S. Sabatini (1993)
Effect of furosemide-induced hypokalemic metabolic alkalosis on renal transport enzymes.Kidney international, 43 5
J. Maaten, K. Damman, J. Hanberg, M. Givertz, M. Metra, C. O'connor, J. Teerlink, P. Ponikowski, G. Cotter, B. Davison, J. Cleland, D. Bloomfield, H. Hillege, D. Veldhuisen, A. Voors, J. Testani (2016)
Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart FailureCirculation: Heart Failure, 9
A. Piala, T. Moon, R. Akella, Haixia He, M. Cobb, E. Goldsmith (2014)
Chloride Sensing by WNK1 Involves Inhibition of AutophosphorylationScience Signaling, 7
J. Hanberg, V. Rao, J. Maaten, J. Maaten, O. Laur, Meredith Brisco, F. Wilson, J. Grodin, Mahlet Assefa, J. Broughton, N. Planavsky, T. Ahmad, L. Bellumkonda, W. Tang, C. Parikh, J. Testani (2016)
Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights.Circulation. Heart failure, 9 8
Y. Chan, B. Biagi, G. Giebisch (1982)
Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule.The American journal of physiology, 242 5
M. Romero (2005)
Molecular pathophysiology of SLC4 bicarbonate transportersCurrent Opinion in Nephrology and Hypertension, 14
J. Grodin, J. Testani, A. Pandey, K. Sambandam, M. Drazner, J. Fang, W. Tang (2018)
Perturbations in serum chloride homeostasis in heart failure with preserved ejection fraction: insights from TOPCATEuropean Journal of Heart Failure, 20
US National Institutes of Health. ClinicalTrials.gov Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure
Roman Marchenko, A. Sigal, T. Wasser, Jessica Reyer, Jared Green, C. Mercogliano, M. Khan, A. Donato (2020)
Hypochloraemia and 30 day readmission rate in patients with acute decompensated heart failureESC Heart Failure, 7
Jen-Chi Chen, Yi-Fen Lo, Ya-Wen Lin, Shih-Hua Lin, Chou-Long Huang, Chih-Jen Cheng (2019)
WNK4 kinase is a physiological intracellular chloride sensorProceedings of the National Academy of Sciences, 116
C. Richardson, D. Alessi (2008)
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathwayJournal of Cell Science, 121
J. Cuthbert, P. Pellicori, A. Rigby, D. Pan, S. Kazmi, P. Shah, A. Clark (2018)
Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significanceEuropean Journal of Heart Failure, 20
J. Grodin, J. Simon, R. Hachamovitch, Yuping Wu, G. Jackson, Meghana Halkar, R. Starling, J. Testani, W. Tang (2015)
Prognostic Role of Serum Chloride Levels in Acute Decompensated Heart Failure.Journal of the American College of Cardiology, 66 6
N. Jeck, H. Seyberth (2010)
Loop Disorders: Insights Derived from Defined GenotypesNephron Physiology, 118
B. Palmer (2011)
Metabolic complications associated with use of diuretics.Seminars in nephrology, 31 6
S. Gandhi, Wassim Mosleh, R. Myers (2014)
Hypertonic saline with furosemide for the treatment of acute congestive heart failure: a systematic review and meta-analysis.International journal of cardiology, 173 2
John Cleland, H. Dargie, Ian Robertson, J. Ian, S. Robertson, B. EASTt, Dr Cleland, Waller Department (1987)
Total body electrolyte composition in patients with heart failure: a comparison with normal subjects and patients with untreated hypertension.British Heart Journal, 58
Aleksandra Sinđić, Min-Hwang Chang, D. Mount, M. Romero (2007)
Renal physiology of SLC26 anion exchangersCurrent Opinion in Nephrology and Hypertension, 16
D. Duan, Luis Liu, Nathan Bozeat, Z. Huang, S. Xiang, Guan-lei Wang, L. Ye, J. Hume (2005)
Functional role of anion channels in cardiac diseasesActa Pharmacologica Sinica, 26
C. Orchard, J. Kentish (1990)
Effects of changes of pH on the contractile function of cardiac muscle.The American journal of physiology, 258 6 Pt 1
R. Star, M. Burg, M. Knepper (1985)
Bicarbonate secretion and chloride absorption by rabbit cortical collecting ducts. Role of chloride/bicarbonate exchange.The Journal of clinical investigation, 76 3
P. Agre, S. Sasaki, M. Chrispeels (1993)
Aquaporins: a family of water channel proteins.The American journal of physiology, 265 3 Pt 2
M. Soleimani, J. Bergman, M Hosford, T McKinney (1990)
Potassium depletion increases luminal Na+/H+ exchange and basolateral Na+:CO3=:HCO3- cotransport in rat renal cortex.The Journal of clinical investigation, 86 4
J. Testani, J. Hanberg, J. Arroyo, Meredith Brisco, J. Maaten, F. Wilson, L. Bellumkonda, D. Jacoby, W. Tang, C. Parikh (2016)
Hypochloraemia is strongly and independently associated with mortality in patients with chronic heart failureEuropean Journal of Heart Failure, 18
W. Boron (2006)
Acid-base transport by the renal proximal tubule.Journal of the American Society of Nephrology : JASN, 17 9
J. Wongboonsin, C. Thongprayoon, T. Bathini, P. Ungprasert, N. Aeddula, M. Mao, W. Cheungpasitporn (2019)
Acetazolamide Therapy in Patients with Heart Failure: A Meta-AnalysisJournal of Clinical Medicine, 8
F. Liu, M. Cogan (1987)
Angiotensin II: a potent regulator of acidification in the rat early proximal convoluted tubule.The Journal of clinical investigation, 80 1
R. Luke, J. Galla (2012)
It is chloride depletion alkalosis, not contraction alkalosis.Journal of the American Society of Nephrology : JASN, 23 2
J. Schnermann, D. Ploth, M. Hermle (1976)
Activation of tubulo-glomerular feedback by chloride transportPflügers Archiv, 362
S. Garella, J. Chazan, J. Cohen (1970)
Saline-resistant metabolic alkalosis or "chloride-wasting nephropathy". Report of four patients with severe potassium depletion.Annals of internal medicine, 73 1
E. Bartoli, A. Satta, R. Faedda, N. Olmeo, G. Soggia, GIAN Branca (1983)
A Furosemide Test in the Functional Evaluation of the Human Nephron in VivoThe Journal of Clinical Pharmacology, 23
Z. Huang, Chaithra Prasad, F. Britton, L. Ye, W. Hatton, D. Duan (2009)
Functional role of CLC-2 chloride inward rectifier channels in cardiac sinoatrial nodal pacemaker cells.Journal of molecular and cellular cardiology, 47 1
L. Cooper, R. Mentz, D. Gallup, Anuradha Lala-Trindade, J. Vader, Omar AbouEzzeddine, J. Butler, B. Bart, Horng Chen, Margaret Redfield, Lynne Stevenson, Christopher O’Connor, K. Anstrom, Adrian Hernandez, G. Felker (2015)
Serum Bicarbonate in Acute Heart Failure: Relationship to Treatment Strategies and Clinical Outcomes.Journal of cardiac failure, 22 9
K. Berend, L. Hulsteijn, R. Gans (2012)
Chloride: the queen of electrolytes?European journal of internal medicine, 23 3
Hypochloraemia is a common electrolyte abnormality in patients with heart failure (HF). It has a strong association with adverse outcome regardless of HF phenotype and independent of other prognostic markers. How hypochloraemia develops in a patient with HF and how it might influence outcome are not clear, and in this review we explore the possible mechanisms. Patients with HF and hypochloraemia almost invariably take higher doses of loop diuretic than patients with normal chloride levels. However, renal chloride and bicarbonate homeostasis are closely linked, and the latter may be influenced by neurohormonal activation: it is likely that the etiology of hypochloraemia in patients with HF is multifactorial and due to more than just diuretic-induced urinary losses. There are multiple proposed mechanisms by which low chloride concentrations may lead to an adverse outcome in patients with HF: by increasing renin release; by a stimulatory effect on the with-no-lysine kinases which might increase renal sodium-chloride co-transporter activity; and by an adverse effect on myocardial conduction and contractility. None of these proposed mechanisms are proven in humans with HF. However, if true, it might suggest that hypochloraemia is a therapeutic target that might be amenable to treatment with acetazolamide or chloride supplementation.
Cardiology and Therapy – Springer Journals
Published: Dec 9, 2020
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