Access the full text.
Sign up today, get DeepDyve free for 14 days.
Z. Horváth, I. Kovalszky, A. Fullár, K. Kiss, Z. Schaff, R. Iozzo, Kornélia Baghy (2014)
Decorin deficiency promotes hepatic carcinogenesis.Matrix biology : journal of the International Society for Matrix Biology, 35
H. Järveläinen, Annele Sainio, M. Koulu, T. Wight, R. Penttinen (2009)
Extracellular Matrix Molecules: Potential Targets in PharmacotherapyPharmacological Reviews, 61
T. Cawthorn, J. Moreno, M. Dharsee, D. Tran‐Thanh, S. Ackloo, P. Zhu, G. Sardana, Jian Chen, P. Kupchak, L. Jacks, N. Miller, B. Youngson, V. Iakovlev, C. Guidos, K. Vallis, K. Evans, D. McCready, W. Leong, S. Done (2012)
Proteomic Analyses Reveal High Expression of Decorin and Endoplasmin (HSP90B1) Are Associated with Breast Cancer Metastasis and Decreased SurvivalPLoS ONE, 7
V. Catalano, A. Turdo, S. Franco, F. Dieli, M. Todaro, G. Stassi (2013)
Tumor and its microenvironment: a synergistic interplay.Seminars in cancer biology, 23 6 Pt B
M. Santra, I. Eichstetter, R. Iozzo (2000)
An Anti-oncogenic Role for DecorinThe Journal of Biological Chemistry, 275
Francesca Cammarota, M. Laukkanen (2015)
Mesenchymal Stem/Stromal Cells in Stromal Evolution and Cancer ProgressionStem Cells International, 2016
H. Järveläinen, Annele Sainio, T. Wight (2015)
Pivotal role for decorin in angiogenesis.Matrix biology : journal of the International Society for Matrix Biology, 43
T. Neill, L. Schaefer, R. Iozzo (2016)
Decorin as a multivalent therapeutic agent against cancer.Advanced drug delivery reviews, 97
K. Mak, Indu Rajapaksha, P. Angus, C. Herath (2017)
The Adeno-associated Virus - A Safe and Promising Vehicle for Liverspecific Gene Therapy of Inherited and Non-inherited Disorders.Current gene therapy, 17 1
A. Theocharis, S. Skandalis, T. Neill, H. Multhaupt, M. Hubo, Helena Frey, Sandeep Gopal, A. Gomes, N. Afratis, H. Lim, J. Couchman, J. Filmus, R. Sanderson, L. Schaefer, R. Iozzo, Nikos Karamanos (2015)
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.Biochimica et biophysica acta, 1855 2
N. Eigėlienė, P. Härkönen, R. Erkkola (2006)
Effects of estradiol and medroxyprogesterone acetate on morphology, proliferation and apoptosis of human breast tissue in organ culturesBMC Cancer, 6
R. Walker (2001)
The complexities of breast cancer desmoplasiaBreast Cancer Research, 3
Hana Andrlová, Justin Mastroianni, J. Madl, J. Kern, W. Melchinger, H. Dierbach, F. Wernet, M. Follo, K. Technau-Hafsi, C. Has, V. Mittapalli, M. Idzko, Ricarda Herr, T. Brummer, H. Ungefroren, H. Busch, M. Boerries, A. Narr, G. Ihorst, C. Vennin, A. Schmitt-Graeff, S. Minguet, P. Timpson, J. Duyster, F. Meiss, W. Römer, R. Zeiser (2017)
Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expressionOncotarget, 8
B. Hennessy, A. González-Angulo, K. Stemke‐Hale, M. Gilcrease, S. Krishnamurthy, Ju-Seog Lee, J. Fridlyand, A. Sahin, R. Agarwal, C. Joy, Wenbin Liu, D. Stivers, K. Baggerly, M. Carey, A. Lluch, C. Monteagudo, Xiaping He, V. Weigman, C. Fan, J. Palazzo, G. Hortobagyi, L. Nolden, Nicholas Wang, V. Valero, J. Gray, C. Perou, G. Mills (2009)
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.Cancer research, 69 10
Y. Zhuang, R. Saaristo, T. Ylikomi (2003)
An in vitro long-term culture model for normal human mammary gland: expression and regulation of steroid receptorsCell and Tissue Research, 311
Hengzi Sun, Xiang Wang, Yifang Zhang, Xiaoxia Che, Zhiming Liu, Li-li Zhang, C. Qiu, Qing-tao Lv, Jie Jiang (2016)
Biglycan enhances the ability of migration and invasion in endometrial cancerArchives of Gynecology and Obstetrics, 293
F. Balkwill, M. Capasso, T. Hagemann (2012)
The tumor microenvironment at a glanceJournal of Cell Science, 125
T. Junttila, M. Laato, T. Vahlberg, K. Söderström, T. Visakorpi, J. Isola, K. Elenius (2003)
Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients.Clinical cancer research : an official journal of the American Association for Cancer Research, 9 14
D. Hanahan, L. Coussens
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Prospects and Obstacles for Therapeutic Targeting of Function-enabling Stromal Cell Types
M. Pérez, Isabel Rodriguez, A. Royloa, Javier Guisasola (2015)
Metaplastic Breast Carcinoma with Unusual Presentation: Review of Three CasesBreast Care, 10
D Hanahan, LM Coussens (2012)
Accessories to the crime: functions of cells recruited to the tumor microenvironmentCancer Cell, 21
Yuefeng Yang, Weidong Xu, T. Neill, Zebin Hu, Chi-Hsiung Wang, Xianghui Xiao, S. Stock, T. Guise, C. Yun, C. Brendler, R. Iozzo, P. Seth (2015)
Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases.Human gene therapy, 26 12
Lanlan Hui, Ye Chen (2015)
Tumor microenvironment: Sanctuary of the devil.Cancer letters, 368 1
D. Shah, Warren Tseng, S. Martinez (2012)
Treatment Options for Metaplastic Breast CancerISRN Oncology, 2012
N. Afratis, C. Gialeli, D. Nikitovic, T. Tsegenidis, E. Karousou, A. Theocharis, M. Pavão, G. Tzanakakis, Nikos Karamanos (2012)
Glycosaminoglycans: key players in cancer cell biology and treatmentThe FEBS Journal, 279
Xiuli Bi, Nicole Pohl, Z. Qian, George Yang, Yuan-bin Gou, G. Guzman, A. Kajdacsy-Balla, R. Iozzo, Wancai Yang (2012)
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice.Carcinogenesis, 33 2
Tsuyoshi Sasaki, H. Tazawa, J. Hasei, Shuhei Osaki, T. Kunisada, Aki Yoshida, Y. Hashimoto, Syuya Yano, R. Yoshida, S. Kagawa, F. Uno, Y. Urata, Toshifumi Ozaki, T. Fujiwara (2012)
A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirusGene Therapy, 20
Jacob Insua-Rodríguez, T. Oskarsson (2016)
The extracellular matrix in breast cancer.Advanced drug delivery reviews, 97
A. Theocharis, S. Skandalis, Chrysostomi Gialeli, Nikos Karamanos (2016)
Extracellular matrix structure.Advanced drug delivery reviews, 97
(2017)
An oncolytic adenovirus encoding decorin and GM-CSF inhibits tumor growth in a colorectal tumor model by targeting pro-tumorigenic signals and via immune-activation
Ken Shintani, A. Matsumine, K. Kusuzaki, J. Morikawa, T. Matsubara, T. Wakabayashi, K. Araki, H. Satonaka, H. Wakabayashi, T. Iino, A. Uchida (2008)
Decorin suppresses lung metastases of murine osteosarcoma.Oncology reports, 19 6
Clifford Whatcott, Haiyong Han, D. Hoff (2015)
Orchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer: Normalization, Not DestructionThe Cancer Journal, 21
S. Troup, C. Njue, E. Kliewer, M. Parisien, C. Roskelley, S. Chakravarti, P. Roughley, L. Murphy, P. Watson (2003)
Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer.Clinical cancer research : an official journal of the American Association for Cancer Research, 9 1
N. Maishi, Y. Ohba, Kosuke Akiyama, N. Ohga, J. Hamada, Hiroko Nagao-Kitamoto, M. Alam, Kazuyuki Yamamoto, T. Kawamoto, N. Inoue, A. Taketomi, M. Shindoh, Y. Hida, K. Hida (2016)
Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycanScientific Reports, 6
N. Arnberg (2012)
Adenovirus receptors: implications for targeting of viral vectors.Trends in pharmacological sciences, 33 8
S Dimmeler, AM Zeiher (2000)
Endothelial cell apoptosis in angiogenesis and vessel regressionCirc Res, 87
Shelly Kaushik, Michael Pickup, V. Weaver (2016)
From transformation to metastasis: deconstructing the extracellular matrix in breast cancerCancer and Metastasis Reviews, 35
K. Araki, H. Wakabayashi, Ken Shintani, J. Morikawa, A. Matsumine, K. Kusuzaki, A. Sudo, A. Uchida (2008)
Decorin Suppresses Bone Metastasis in a Breast Cancer Cell LineOncology, 77
Jeffry Dean, A. McClendon, Theresa Hickey, L. Butler, W. Tilley, A. Witkiewicz, E. Knudsen (2012)
Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumorsCell Cycle, 11
Z. Werb, Pengfei Lu (2015)
The Role of Stroma in Tumor Development.Cancer journal, 21 4
Antonio Wolff, M. Hammond, David Hicks, M. Dowsett, Lisa Mcshane, Kimberly Allison, D. Allred, John Bartlett, M. Bilous, P. Fitzgibbons, W. Hanna, Robert Jenkins, P. Mangu, S. Paik, Edith Perez, Michael Press, Patricia Spears, Gail Vance, G. Viale, Daniel Hayes (2014)
Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.Archives of pathology & laboratory medicine, 138 2
D Hanahan, RA Weinberg (2000)
The hallmarks of cancerCell, 100
A. Wolff, M. Hammond, D. Hicks, M. Dowsett, L. McShane, K. Allison, D. Allred, J. Bartlett, M. Bilous, P. Fitzgibbons, W. Hanna, Robert Jenkins, P. Mangu, S. Paik, E. Perez, M. Press, P. Spears, G. Vance, G. Viale, D. Hayes (2013)
Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31 31
N. Dhomen, J. Mariadason, N. Tebbutt, A. Scott (2012)
Therapeutic targeting of the epidermal growth factor receptor in human cancer.Critical reviews in oncogenesis, 17 1
T. Järvinen, Stuart Prince (2015)
Decorin: A Growth Factor Antagonist for Tumor Growth InhibitionBioMed Research International, 2015
Tony Gutschner, S. Diederichs (2012)
The hallmarks of cancerRNA Biology, 9
Pengfei Lu, K. Takai, V. Weaver, Z. Werb (2011)
Extracellular matrix degradation and remodeling in development and disease.Cold Spring Harbor perspectives in biology, 3 12
Yongcan Xu, Q. Xia, Q. Rao, S. Shi, Q. Shi, Heng‐hui Ma, Zhen‐feng Lu, Hui Chen, Xiao-jun Zhou (2016)
DCN deficiency promotes renal cell carcinoma growth and metastasis through downregulation of P21 and E-cadherinTumor Biology, 37
Annele Sainio, H. Järveläinen (2014)
Extracellular matrix macromolecules: potential tools and targets in cancer gene therapyMolecular and cellular therapies, 2
Pengfei Lu, V. Weaver, Z. Werb (2012)
The extracellular matrix: A dynamic niche in cancer progressionThe Journal of Cell Biology, 196
H. Järveläinen, M. Kinsella, T. Wight, L. Sandell (1991)
Differential expression of small chondroitin/dermatan sulfate proteoglycans, PG-I/biglycan and PG-II/decorin, by vascular smooth muscle and endothelial cells in culture.The Journal of biological chemistry, 266 34
Xiaojing Xing, Xiaohu Gu, Tianfei Ma, Huinan Ye (2015)
Biglycan up-regulated vascular endothelial growth factor (VEGF) expression and promoted angiogenesis in colon cancerTumor Biology, 36
F. Geyer, Maryou Lambros, R. Natrajan, R. Mehta, A. Mackay, K. Savage, S. Parry, A. Ashworth, S. Badve, J. Reis-Filho (2010)
Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breastModern Pathology, 23
O. Jungmann, K. Nikolovska, C. Stock, Jan-Niklas Schulz, B. Eckes, C. Riethmüller, R. Owens, R. Iozzo, D. Seidler (2012)
The Dermatan Sulfate Proteoglycan Decorin Modulates α2β1 Integrin and the Vimentin Intermediate Filament System during Collagen SynthesisPLoS ONE, 7
E. Leygue, L. Snell, Helmut Dotzlaw, S. Troup, T. Hiller‐Hitchcock, L. Murphy, P. Roughley, P. Watson (2000)
Lumican and decorin are differentially expressed in human breast carcinomaThe Journal of Pathology, 192
Emma Watson, Zoe Grant, L. Coultas (2017)
Endothelial cell apoptosis in angiogenesis and vessel regressionCellular and Molecular Life Sciences, 74
R. Iozzo, D. Moscatello, D. McQuillan, I. Eichstetter (1999)
Decorin Is a Biological Ligand for the Epidermal Growth Factor Receptor*The Journal of Biological Chemistry, 274
Sausan Abouharb, S. Moulder (2015)
Metaplastic Breast Cancer: Clinical Overview and Molecular Aberrations for Potential Targeted TherapyCurrent Oncology Reports, 17
D. Feugaing, M. Götte, M. Viola (2013)
More than matrix: the multifaceted role of decorin in cancer.European journal of cell biology, 92 1
L. Fiedler, E. Schönherr, R. Waddington, S. Niland, D. Seidler, D. Aeschlimann, J. Eble (2008)
Decorin Regulates Endothelial Cell Motility on Collagen I through Activation of Insulin-like Growth Factor I Receptor and Modulation of α2β1 Integrin Activity*Journal of Biological Chemistry, 283
M. Santra, M. Katakowski, R. Zhang, He Meng, F. Jiang, M. Chopp (2006)
Protection of Adult Mouse Progenitor Cells and Human Glioma Cells by de novo Decorin Expression in an Oxygen- and Glucose-Deprived Cell Culture Model SystemJournal of Cerebral Blood Flow & Metabolism, 26
I. Chen, Ching-Hung Lin, Chiun-Sheng Huang, H. Lien, Chiun Hsu, W. Kuo, Yen-Shen Lu, A. Cheng (2011)
Lack of efficacy to systemic chemotherapy for treatment of metaplastic carcinoma of the breast in the modern eraBreast Cancer Research and Treatment, 130
B. Kubista, Florian Klinglmueller, M. Bilban, M. Pfeiffer, R. Lass, A. Giurea, P. Funovics, C. Toma, M. Dominkus, R. Kotz, T. Thalhammer, K. Trieb, T. Zettl, C. Singer (2011)
Microarray analysis identifies distinct gene expression profiles associated with histological subtype in human osteosarcomaInternational Orthopaedics, 35
A. Zafiropoulos, D. Nikitovic, P. Katonis, A. Tsatsakis, Nikos Karamanos, G. Tzanakakis (2008)
Decorin-Induced Growth Inhibition Is Overcome through Protracted Expression and Activation of Epidermal Growth Factor Receptors in Osteosarcoma CellsMolecular Cancer Research, 6
S. Lakhani (2012)
WHO classification of tumours of the breast
P. Bianco, L. Fisher, M. Young, J. Termine, P. Robey (1990)
Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 38
Henriikka Salomäki, Annele Sainio, M. Söderström, Sari Pakkanen, J. Laine, H. Järveläinen (2008)
Differential Expression of Decorin by Human Malignant and Benign Vascular TumorsJournal of Histochemistry & Cytochemistry, 56
S. Goldoni, D. Seidler, J. Heath, M. Fassan, R. Baffa, M. Thakur, R. Owens, D. McQuillan, R. Iozzo (2008)
An antimetastatic role for decorin in breast cancer.The American journal of pathology, 173 3
Yanhong Zhang, K. Toy, C. Kleer (2012)
Metaplastic breast carcinomas are enriched in markers of tumor-initiating cells and epithelial to mesenchymal transitionModern Pathology, 25
L. Brown, Anthony Guidi, S. Schnitt, L. Water, M. Iruela-Arispe, T. Yeo, K. Tognazzi, H. Dvorak (1999)
Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast.Clinical cancer research : an official journal of the American Association for Cancer Research, 5 5
(2013)
Biological functions of decorin in cancer
Annele Sainio, Marie Nyman, R. Lund, Sanna Vuorikoski, P. Boström, M. Laato, P. Boström, H. Järveläinen (2013)
Lack of Decorin Expression by Human Bladder Cancer Cells Offers New Tools in the Therapy of Urothelial MalignanciesPLoS ONE, 8
E. Rakha, P. Tan, Z. Varga, G. Tse, A. Shaaban, F. Climent, C. Deurzen, D. Purnell, D. Dodwell, T. Chan, I. Ellis (2014)
Prognostic factors in metaplastic carcinoma of the breast: a multi-institutional studyBritish Journal of Cancer, 112
L. Schaefer, R. Iozzo (2008)
Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction*Journal of Biological Chemistry, 283
Michael Pickup, J. Mouw, V. Weaver (2014)
The extracellular matrix modulates the hallmarks of cancerEMBO reports, 15
T. Oskarsson (2013)
Extracellular matrix components in breast cancer progression and metastasis.Breast, 22 Suppl 2
(2015)
Decorin in human Colon cancer: localization in vivo and effect on cancer cell behavior in vitro
M. Dieci, E. Orvieto, M. Dominici, P. Conte, V. Guarneri (2014)
Rare breast cancer subtypes: histological, molecular, and clinical peculiarities.The oncologist, 19 8
P. Boström, Annele Sainio, T. Kakko, M. Savontaus, M. Söderström, H. Järveläinen (2012)
Localization of decorin gene expression in normal human breast tissue and in benign and malignant tumors of the human breastHistochemistry and Cell Biology, 139
Cristiano Farace, J. Oliver, C. Melguizo, P. Álvarez, P. Bandiera, A. Rama, G. Malaguarnera, R. Ortiz, R. Madeddu, J. Prados (2015)
Microenvironmental Modulation of Decorin and Lumican in Temozolomide-Resistant Glioblastoma and Neuroblastoma Cancer Stem-Like CellsPLoS ONE, 10
Jing-xu Zhu, S. Goldoni, G. Bix, R. Owens, D. McQuillan, C. Reed, R. Iozzo (2005)
Decorin Evokes Protracted Internalization and Degradation of the Epidermal Growth Factor Receptor via Caveolar Endocytosis*Journal of Biological Chemistry, 280
T. Neill, Annabel Torres, Simone Buraschi, R. Owens, J. Hoek, R. Baffa, R. Iozzo (2014)
Decorin Induces Mitophagy in Breast Carcinoma Cells via Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and Mitostatin*The Journal of Biological Chemistry, 289
Yanni Song, Xiaolong Liu, Guoqiang Zhang, Hongtao Song, Yanlv Ren, Xiao-Guang He, Yanbo Wang, Jin-feng Zhang, You-xue Zhang, Shan-shan Sun, Xiaoshuan Liang, Qian Sun, D. Pang (2013)
Unique clinicopathological features of metaplastic breast carcinoma compared with invasive ductal carcinoma and poor prognostic indicatorsWorld Journal of Surgical Oncology, 11
Annele Sainio (2013)
Extracellular Matrix Macromolecules in Tumour Microenvironment with Special Reference to Desmoplastic Reaction and the Role of Matrix Proteoglycans and HyaluronanJournal of carcinogenesis & mutagenesis, 2013
B. Bozóky, Andrii Savchenko, H. Guvén, F. Pontén, G. Klein, L. Szekely (2014)
Decreased decorin expression in the tumor microenvironmentCancer Medicine, 3
Shuangjiang Li, Da-li Chen, Wen-Biao Zhang, Cheng Shen, G. Che (2015)
Prognostic value of stromal decorin expression in patients with breast cancer: a meta-analysis.Journal of thoracic disease, 7 11
D. Nikitovic, Katerina Kouvidi, Kallirroi Voudouri, A. Berdiaki, E. Karousou, A. Passi, G. Tzanakakis (2014)
The Motile Breast Cancer Phenotype Roles of Proteoglycans/GlycosaminoglycansBioMed Research International, 2014
X. Sastre-Garau, P. Génin, A. Rousseau, A. Ghuzlan, A. Nicolas, P. Fréneaux, C. Rosty, B. Sigal‐Zafrani, J. Couturier, J. Thiery, H. Magdelenat, A. Vincent-Salomon (2004)
Increased cell size and Akt activation in HER‐2/neu‐overexpressing invasive ductal carcinoma of the breastHistopathology, 45
Y. Kang, Shu Kang, Qingchang Li, Xinyu Zheng (2014)
Mixed epithelial and mesenchymal metaplastic carcinoma (carcinosarcoma) of the breast: a case reportEuropean Journal of Medical Research, 19
T. Neill, L. Schaefer, R. Iozzo (2015)
Oncosuppressive functions of decorinMolecular & Cellular Oncology, 2
T. Chien, J. Chou, T. Chang, Chetpin Lin (2010)
Successful treatment of biphasic metaplastic sarcomatoid carcinoma of the breast by evaluation of immunohistochemical markers.Hematology/oncology and stem cell therapy, 3 2
Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM). However, little is known about the composition of the ECM and its constituents in MBC. Decorin is a ubiquitous ECM macromolecule known of its oncosuppressive activity. As such, it provides an intriguing molecule in the development of novel therapeutics for different malignancies such as MBC. In this study, decorin immunoreactivity and the effect of adenoviral decorin cDNA (Ad-DCN) transduction were examined in MBC. Multiple immunohistochemical stainings were used to characterize a massive breast tumour derived from an old woman. Furthermore, three-dimensional (3D) explant cultures derived from the tumour were transduced with Ad-DCN to study the effect of the transduction on the explants. The MBC tumour was shown to be completely negative for decorin immunoreactivity demonstrating that the malignant cells were not able to synthesize decorin. Ad-DCN transduction resulted in a markedly altered cytological phenotype of MBC explants by decreasing the amount of atypical cells and by inhibiting cell proliferation. The results of this study support approaches to develop new, decorin-based adjuvant therapies for MBC.
Cancer Microenvironment – Springer Journals
Published: Jun 26, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.