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Human Clock Genes and Cancer

Human Clock Genes and Cancer Purpose of Review Modern social life often demands aberrant light exposures (i.e., jet lag, shift work, or nocturnal life style), which results in desynchronization and misalignment of circadian rhythms. Experimental and epidemiological data suggest that circadian disruption, caused by genetic manipulations or forced light/dark conditions, promotes cancerogenesis. Human genetic studies highlight the contribution of individual clock genes to this process, though the exact function is somewhat controversial. Recent Findings Multiple reports demonstrate an association of genetic variations within clock genes with risk of tumor devel- opment. Mutations or deregulated expression of clock genes are frequently detected in different tumors and often show corre- lation with cancer progression and patient prognosis. Cellular studies report contradictory results that clock genes can inhibit as well as support tumor growth and proliferation in different cells. Summary Clock genes appear to have multifaceted functions during cancer development and can act both as tumor suppressors or promote cancerogenesis depending on the particular type of tumor. However, the exact conditions and factors which determine such behavior remain elusive and must be investigated in future studies. . . . . Keywords Clock genes Circadian clock Cancer SNP Mutation Introduction humoral and neuronal pathways, or temperature, is crucial http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sleep Medicine Reports Springer Journals

Human Clock Genes and Cancer

Shostak, Anton
Current Sleep Medicine Reports , Volume 4 (1) – Feb 12, 2018
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References (114)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Internal Medicine; General Practice / Family Medicine; Otorhinolaryngology; Neurology; Cardiology; Psychiatry
eISSN
2198-6401
DOI
10.1007/s40675-018-0102-y
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Modern social life often demands aberrant light exposures (i.e., jet lag, shift work, or nocturnal life style), which results in desynchronization and misalignment of circadian rhythms. Experimental and epidemiological data suggest that circadian disruption, caused by genetic manipulations or forced light/dark conditions, promotes cancerogenesis. Human genetic studies highlight the contribution of individual clock genes to this process, though the exact function is somewhat controversial. Recent Findings Multiple reports demonstrate an association of genetic variations within clock genes with risk of tumor devel- opment. Mutations or deregulated expression of clock genes are frequently detected in different tumors and often show corre- lation with cancer progression and patient prognosis. Cellular studies report contradictory results that clock genes can inhibit as well as support tumor growth and proliferation in different cells. Summary Clock genes appear to have multifaceted functions during cancer development and can act both as tumor suppressors or promote cancerogenesis depending on the particular type of tumor. However, the exact conditions and factors which determine such behavior remain elusive and must be investigated in future studies. . . . . Keywords Clock genes Circadian clock Cancer SNP Mutation Introduction humoral and neuronal pathways, or temperature, is crucial

Journal

Current Sleep Medicine Reports – Springer Journals

Published: Feb 12, 2018

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