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Heritability of Sleep and Its Disorders in Childhood and Adolescence

Heritability of Sleep and Its Disorders in Childhood and Adolescence Purpose of ReviewThis review summarizes recent literature on the heritability of sleep and sleep disorders in childhood and adolescence. We also identify gaps in the literature and priorities for future research.Recent FindingsFindings indicate that age, measurement method, reporter, and timing of sleep measurements can influence heritability estimates. Recent genome-wide association studies (GWAS) have identified differences in the heritability of sleep problems when ancestral differences are considered, but sample sizes are small compared to adult GWAS. Most studies focus on sleep variables in the full range rather than on disorder. Studies using objective measures of sleep typically comprised small samples.SummaryCurrent evidence demonstrates a wide range of heritability estimates across sleep phenotypes in childhood and adolescence, but research in larger samples, particularly using objective sleep measures and GWAS, is needed. Further understanding of environmental mechanisms and the interaction between genes and environment is key for future research. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sleep Medicine Reports Springer Journals

Heritability of Sleep and Its Disorders in Childhood and Adolescence

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References (89)

Publisher
Springer Journals
Copyright
Copyright © Crown 2021
eISSN
2198-6401
DOI
10.1007/s40675-021-00216-z
Publisher site
See Article on Publisher Site

Abstract

Purpose of ReviewThis review summarizes recent literature on the heritability of sleep and sleep disorders in childhood and adolescence. We also identify gaps in the literature and priorities for future research.Recent FindingsFindings indicate that age, measurement method, reporter, and timing of sleep measurements can influence heritability estimates. Recent genome-wide association studies (GWAS) have identified differences in the heritability of sleep problems when ancestral differences are considered, but sample sizes are small compared to adult GWAS. Most studies focus on sleep variables in the full range rather than on disorder. Studies using objective measures of sleep typically comprised small samples.SummaryCurrent evidence demonstrates a wide range of heritability estimates across sleep phenotypes in childhood and adolescence, but research in larger samples, particularly using objective sleep measures and GWAS, is needed. Further understanding of environmental mechanisms and the interaction between genes and environment is key for future research.

Journal

Current Sleep Medicine ReportsSpringer Journals

Published: Dec 1, 2021

Keywords: Adolescence; Childhood; Circadian rhythms; Heritability; Sleep

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