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Hepatocurative effect of aqueous extract of Scoparia dulcis (sweet broom) root on carbon tetrachloride-induced hepatotoxicity in albino rats

Hepatocurative effect of aqueous extract of Scoparia dulcis (sweet broom) root on carbon... Most acute and chronic liver diseases today are due to drugs and other chemical-induced hepatotoxicity. A great number of herbal preparations have become increasingly popular for the treatment of liver disorders due to the absence of reliable hepatoprotective drugs in modern medicine. The aim of this work is to carry out acute toxicity study and investigate the hepatocurative effects of aqueous root extract of Scoparia dulcis against carbon tetrachloride (CCl4)-induced hepatoxicity in albino rats. Serum biomarkers of hepatic injury, alanine aminotransferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), albumine (ALB), and bilirubin, were assayed according to standard methods. The results of the biochemical studies of blood samples of CCl4-treated rats showed significant (P ˂ 0.05) increase in the levels of ALT and AST and decrease in ALB level reflecting the liver injury caused by CCl4 whereas blood samples from rats treated with aqueous root extract of Scoparia dulcis showed decreased levels of ALT and AST and increase in ALB indicating the protection of hepatic cells. Histopathological features showed decreased infiltration of inflammatory cells, staetosis, and level of fibrosis in the liver tissues of the treated compared to the untreated groups. This further confirms the hepatocurative effect of Scoparia dulcis extract. The lethal dose (LD50) of the root extract was greater than 5000 mg/kg. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Hepatocurative effect of aqueous extract of Scoparia dulcis (sweet broom) root on carbon tetrachloride-induced hepatotoxicity in albino rats

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References (68)

Publisher
Springer Journals
Copyright
Copyright © Springer-Verlag London Ltd., part of Springer Nature 2020
eISSN
1618-565X
DOI
10.1007/s00580-020-03120-0
Publisher site
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Abstract

Most acute and chronic liver diseases today are due to drugs and other chemical-induced hepatotoxicity. A great number of herbal preparations have become increasingly popular for the treatment of liver disorders due to the absence of reliable hepatoprotective drugs in modern medicine. The aim of this work is to carry out acute toxicity study and investigate the hepatocurative effects of aqueous root extract of Scoparia dulcis against carbon tetrachloride (CCl4)-induced hepatoxicity in albino rats. Serum biomarkers of hepatic injury, alanine aminotransferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), albumine (ALB), and bilirubin, were assayed according to standard methods. The results of the biochemical studies of blood samples of CCl4-treated rats showed significant (P ˂ 0.05) increase in the levels of ALT and AST and decrease in ALB level reflecting the liver injury caused by CCl4 whereas blood samples from rats treated with aqueous root extract of Scoparia dulcis showed decreased levels of ALT and AST and increase in ALB indicating the protection of hepatic cells. Histopathological features showed decreased infiltration of inflammatory cells, staetosis, and level of fibrosis in the liver tissues of the treated compared to the untreated groups. This further confirms the hepatocurative effect of Scoparia dulcis extract. The lethal dose (LD50) of the root extract was greater than 5000 mg/kg.

Journal

Comparative Clinical Pathology – Springer Journals

Published: May 25, 2020

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