Access the full text.
Sign up today, get DeepDyve free for 14 days.
Salah Tawill, L. Goff, Fahimeda Ali, M. Blaxter, J. Allen (2004)
Both Free-Living and Parasitic Nematodes Induce a Characteristic Th2 Response That Is Dependent on the Presence of Intact GlycansInfection and Immunity, 72
P. Matricardi, F. Rosmini, S. Riondino, M. Fortini, L. Ferrigno, M. Rapicetta, S. Bonini (2000)
Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological studyBMJ : British Medical Journal, 320
R. Aalberse, T. Platts-Mills (2004)
How do we avoid developing allergy: modifications of the TH2 response from a B-cell perspective.The Journal of allergy and clinical immunology, 113 5
P. Thomas, M. Carter, O. Atochina, A. Da'dara, D. Piskorska, E. McGuire, D. Harn (2003)
Maturation of Dendritic Cell 2 Phenotype by a Helminth Glycan Uses a Toll-Like Receptor 4-Dependent Mechanism 1The Journal of Immunology, 171
J. Riedler, C. Braun‐Fahrländer, W. Eder, M. Schreuer, M. Waser, S. Maisch, D. Carr, R. Schierl, D. Nowak, E. Mutius (2001)
Exposure to farming in early life and development of asthma and allergy: a cross-sectional surveyThe Lancet, 358
M. Bashir, P. Andersen, I. Fuss, H. Shi, C. Nagler‐Anderson (2002)
An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen1The Journal of Immunology, 169
M. Rodríguez-Sosa, A. Satoskar, Rodrigo Calderón, L. Gómez-García, R. Saavedra, R. Bojalil, L. Terrazas (2002)
Chronic Helminth Infection Induces Alternatively Activated Macrophages Expressing High Levels of CCR5 with Low Interleukin-12 Production and Th2-Biasing AbilityInfection and Immunity, 70
C. Faveeuw, T. Mallevaey, K. Paschinger, I. Wilson, J. Fontaine, R. Mollicone, R. Oriol, F. Altmann, P. Lerouge, M. Capron, F. Trottein (2003)
Schistosome N‐glycans containing core α3‐fucose and core β2‐xylose epitopes are strong inducers of Th2 responses in miceEuropean Journal of Immunology, 33
R. Beasley (1998)
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAACThe Lancet, 351
N. Sudo, S. Sawamura, Kazuo Tanaka, Y. Aiba, C. Kubo, Y. Koga (1997)
The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction.Journal of immunology, 159 4
L. Terrazas, Kristen Walsh, D. Piskorska, E. McGuire, D. Harn (2001)
The Schistosome Oligosaccharide Lacto-N-neotetraose Expands Gr1+ Cells That Secrete Anti-inflammatory Cytokines and Inhibit Proliferation of Naive CD4+ Cells: A Potential Mechanism for Immune Polarization in Helminth InfectionsThe Journal of Immunology, 167
A. Doetze, J. Satoguina, G. Burchard, T. Rau, C. Löliger, B. Fleischer, A. Hoerauf (2000)
Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by Th3/Tr1-type cytokines IL-10 and transforming growth factor-β but not by a Th1 to Th2 shiftInternational Immunology, 12
A. McKee, E. Pearce (2004)
CD25+CD4+ Cells Contribute to Th2 Polarization during Helminth Infection by Suppressing Th1 Response Development1The Journal of Immunology, 173
M. Araújo, A. Lopes, M. Medeiros, Á. Cruz, Luiza Sousa-Atta, D. Solé, E. Carvalho (2000)
Inverse Association between Skin Response to Aeroallergens and Schistosoma mansoni InfectionInternational Archives of Allergy and Immunology, 123
O. Nyan, G. Walraven, Winston Banya, P. Milligan, M. Sande, S. Ceesay, G. Prete, K. McAdam (2001)
Atopy, intestinal helminth infection and total serum IgE in rural and urban adult Gambian communitiesClinical & Experimental Allergy, 31
I. Die, S. Vliet, A. Nyame, R. Cummings, C. Bank, B. Appelmelk, T. Geijtenbeek, Y. Kooyk (2003)
The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x.Glycobiology, 13 6
J. Grogan, P. Kremsner, A. Deelder, M. Yazdanbakhsh (1998)
Antigen-specific proliferation and interferon-gamma and interleukin-5 production are down-regulated during Schistosoma haematobium infection.The Journal of infectious diseases, 177 5
P. Cooper, M. Chico, L. Rodrigues, Marisol Ordóñez, D. Strachan, G. Griffin, T. Nutman (2003)
Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics.The Journal of allergy and clinical immunology, 111 5
P. Loke, A. MacDonald, A. Robb, R. Maizels, J. Allen (2000)
Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell‐to‐cell contactEuropean Journal of Immunology, 30
D. Strachan (1989)
Hay fever, hygiene, and household size.British Medical Journal, 299
M. Redondo, P. Fain, G. Eisenbarth (2001)
Genetics of type 1A diabetes.Recent progress in hormone research, 56
D. Elliott, Jie Li, A. Blum, A. Metwali, K. Qadir, J. Urban, J. Weinstock (2003)
Exposure to schistosome eggs protects mice from TNBS-induced colitis.American journal of physiology. Gastrointestinal and liver physiology, 284 3
MC Kullberg (1992)
3264J Immunol, 148
D. Negrão-Corrêa, M. Silveira, Cynthia Borges, D. Souza, M. Teixeira (2003)
Changes in Pulmonary Function and Parasite Burden in Rats Infected with Strongyloides venezuelensis Concomitant with Induction of Allergic Airway InflammationInfection and Immunity, 71
M. Okano, A. Satoskar, K. Nishizaki, D. Harn (2001)
Lacto-N-fucopentaose III Found on Schitosoma mansoni Egg Antigens Functions as Adjuvant for Proteins by Inducing Th2-Type Response1The Journal of Immunology, 167
N Sudo (1997)
1739J Immunol, 159
P Jeannin (1998)
3555J Immunol, 160
M. Holland, Y. Harcus, P. Riches, R. Maizels (2000)
Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responsesEuropean Journal of Immunology, 30
J. Actor, M. Shirai, M. Kullberg, R. Buller, Alan Sher, J. Berzofsky (1993)
Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance.Proceedings of the National Academy of Sciences of the United States of America, 90
U. Krämer, J. Heinrich, M. Wjst, H. Wichmann (1999)
Age of entry to day nursery and allergy in later childhoodThe Lancet, 353
Elizabeth Sabin, M. Araújo, Edgar Carvalho, Edward Pearce (1996)
Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni.The Journal of infectious diseases, 173 1
A. Balic, Y. Harcus, M. Holland, R. Maizels (2004)
Selective maturation of dendritic cells by Nippostrongylus brasiliensis‐secreted proteins drives Th2 immune responsesEuropean Journal of Immunology, 34
Mathieu Nacher, P. Singhasivanon, B. Traoré, S. Dejvorakul, W. Phumratanaprapin, S. Looareesuwan, F. Gay (2001)
Short report: Hookworm infection is associated with decreased body temperature during mild Plasmodium falciparum malaria.The American journal of tropical medicine and hygiene, 65 2
E. Sepp, K. Julge, M. Vasar, P. Naaber, B. Björkstén, Marika Mikelsaar (1997)
Intestinal microflora of Estonian and Swedish infantsActa Pædiatrica, 86
P. Onkamo, Saara Väänänen, M. Karvonen, J. Tuomilehto (1999)
Worldwide increase in incidence of Type I diabetes – the analysis of the data on published incidence trendsDiabetologia, 42
P. Cooper, I. Espinel, W. Paredes, R. Guderian, T. Nutman (1998)
Impaired tetanus-specific cellular and humoral responses following tetanus vaccination in human onchocerciasis: a possible role for interleukin-10.The Journal of infectious diseases, 178 4
J. Alm, J. Swartz, G. Lilja, A. Scheynius, G. Pershagen (1999)
Atopy in children of families with an anthroposophic lifestyleThe Lancet, 353
N. Lynch, I. Hagel, Mireya Perez, M. Prisco, R. López, N. Alvarez (1993)
Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum.The Journal of allergy and clinical immunology, 92 3
A Kurniawan (1993)
3941J Immunol, 150
Diane Sewell, Z. Qing, E. Reinke, David Elliot, J. Weinstock, M. Sandor, Z. Fabry (2003)
Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization.International immunology, 15 1
Sarah Scrivener, Haile Yemaneberhan, M. Zebenigus, Daniel Tilahun, S. Girma, S. Ali, P. McElroy, A. Custovic, A. Woodcock, D. Pritchard, A. Venn, J. Britton (2001)
Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control studyThe Lancet, 358
I. Adlerberth, B. Carlsson, P. Man, F. Jalil, SHAUKAT Khan, P. Larsson, L. Mellander, C. Svanborg, A. Wold, L. Hanson (1991)
Intestinal Colonization with Enterobacteriaceae in Pakistani and Swedish Hospital‐Delivered InfantsActa Pædiatrica, 80
J. Satoguina, M. Mempel, J. Larbi, Marlis Badusche, C. Löliger, O. Adjei, G. Gachelin, B. Fleischer, A. Hoerauf (2002)
Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis).Microbes and infection, 4 13
R. Hussain, R. Poindexter, Eric Ottesen (1992)
Control of allergic reactivity in human filariasis. Predominant localization of blocking antibody to the IgG4 subclass.Journal of immunology, 148 9
PM Matricardi (2001)
413Curr Opin Allergy Clin Immunol, 1
D. Kleij, E. Latz, J. Brouwers, Y. Kruize, M. Schmitz, E. Kurt-Jones, T. Espevik, E. Jong, M. Kapsenberg, D. Golenbock, A. Tielens, M. Yazdanbakhsh (2002)
A Novel Host-Parasite Lipid Cross-talkThe Journal of Biological Chemistry, 277
J. Fox, P. Beck, C. Dangler, M. Whary, T. Wang, H. Shi, C. Nagler‐Anderson (2000)
Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophyNature Medicine, 6
A. Biggelaar, L. Rodrigues, R. Ree, J. Zee, Yvonne Hoeksma-Kruize, J. Souverijn, M. Missinou, S. Borrmann, P. Kremsner, M. Yazdanbakhsh (2004)
Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren.The Journal of infectious diseases, 189 5
N. Lynch, R. López, MARÍA PRISCO‐FUENMAYOR, I. Hagel, Luisa Medouze, G. Viana, C. Ortega, G. Prato (1987)
Allergic reactivity and socio‐economic level in a tropical environmentClinical & Experimental Allergy, 17
P. Matricardi, R. Ronchetti (2001)
Are infections protecting from atopy?Current Opinion in Allergy and Clinical Immunology, 1
C. Zuany‐Amorim, E. Sawicka, C. Manlius, A. Moine, L. Brunet, D. Kemeny, G. Bowen, G. Rook, C. Walker (2002)
Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cellsNature Medicine, 8
M. Kapsenberg (2003)
Dendritic-cell control of pathogen-driven T-cell polarizationNature Reviews Immunology, 3
T. Platts-Mills, J. Vaughan, S. Squillace, J. Woodfolk, R. Sporik (2001)
Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional studyThe Lancet, 357
I. Adlerberth, Fehmida Jalil, Barbro Carlsson, L. Mellander, Lars Hanson, Peter Larsson, K. Khalil, Agnes Wold (1998)
High turnover rate of Escherichia coli strains in the intestinal flora of infants in PakistanEpidemiology and Infection, 121
Chun‐Chi Wang, T. Nolan, G. Schad, David Abraham (2001)
Infection of mice with the helminth Strongyloides stercoralis suppresses pulmonary allergic responses to ovalbuminClinical & Experimental Allergy, 31
A. Cooke, P. Tonks, F. Jones, H. O'Shea, P. Hutchings, A. Fulford, Dunne (1999)
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic miceParasite Immunology, 21
Jannie Buijs, Gerard Borsboom, Justus Gemund, Alice Hazebroek, Paul Dongen, F. Knapen, H. Neijens (1994)
Toxocara seroprevalence in 5-year-old elementary schoolchildren: relation with allergic asthma.American journal of epidemiology, 140 9
J. Kim, M. Ohsawa (1995)
Oral tolerance to ovalbumin in mice as a model for detecting modulators of the immunologic tolerance to a specific antigen.Biological & pharmaceutical bulletin, 18 6
C. Todd, R. Goodgame, D. Colley (1979)
Immune responses during human schistosomiasis mansoni. V. Suppression of schistosome antigen-specific lymphocyte blastogenesis by adherent/phagocytic cells.Journal of immunology, 122 4
Mathieu Nacher, F. Gay, P. Singhasivanon, S. Krudsood, S. Treeprasertsuk, D. Mazier, I. Vouldoukis, S. Looareesuwan (2000)
Ascaris lumbricoides infection is associated with protection from cerebral malariaParasite Immunology, 22
C. Braun‐Fahrländer, J. Riedler, U. Herz, W. Eder, M. Waser, L. Grize, S. Maisch, D. Carr, Florian Gerlach, A. Bufe, R. Lauener, R. Schierl, H. Renz, D. Nowak, E. Mutius (2002)
Environmental exposure to endotoxin and its relation to asthma in school-age children.The New England journal of medicine, 347 12
A. Linneberg, C. Ostergaard, M. Tvede, L. Andersen, N. Nielsen, F. Madsen, L. Frølund, A. Dirksen, T. Jørgensen (2003)
IgG antibodies against microorganisms and atopic disease in Danish adults: the Copenhagen Allergy Study.The Journal of allergy and clinical immunology, 111 4
R. Strien, R. Engel, O. Holst, A. Bufe, W. Eder, M. Waser, C. Braun‐Fahrländer, J. Riedler, D. Nowak, E. Mutius (2004)
Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health.The Journal of allergy and clinical immunology, 113 5
Daocheng Zhu, C. Kepley, Min Zhang, K. Zhang, A. Saxon (2002)
A novel human immunoglobulin Fcγ–Fcɛ bifunctional fusion protein inhibits FcɛRI-mediated degranulationNature Medicine, 8
C. Lima, A. Perini, M. Garcia, M. Martins, M. Teixeira, M. Macedo (2002)
Eosinophilic inflammation and airway hyper‐responsiveness are profoundly inhibited by a helminth (Ascaris suum) extract in a murine model of asthmaClinical & Experimental Allergy, 32
A. Spiegel, A. Tall, G. Raphenon, J. Trape, P. Druilhe (2003)
Increased frequency of malaria attacks in subjects co-infected by intestinal worms and Plasmodium falciparum malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene, 97 2
W. Piessens, S. Ratiwayanto, S. Tuti, J. Palmieri, P. Piessens, I. Koiman, D. Dennis (1980)
Antigen-specific suppressor cells and suppressor factors in human filariasis with Brugia malayi.The New England journal of medicine, 302 15
G. Wohlleben, C. Trujillo, Justus Müller, Y. Ritze, S. Grunewald, Ursula Tatsch, K. Erb (2004)
Helminth infection modulates the development of allergen-induced airway inflammation.International immunology, 16 4
A. Kurniawan, M. Yazdanbakhsh, R. Ree, R. Aalberse, M. Selkirk, F. Partono, R. Maizels (1993)
Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis.Journal of immunology, 150 9
E. Pearce, Colleen Kane, Jie Sun, Justin Taylor, A. McKee, L. Cervi (2004)
Th2 response polarization during infection with the helminth parasite Schistosoma mansoniImmunological Reviews, 201
B. Björkstén, P. Naaber, E. Sepp, M. Mikelsaar (1999)
The intestinal microflora in allergic Estonian and Swedish 2‐year‐old childrenClinical & Experimental Allergy, 29
A. Biggelaar, R. Ree, L. Rodrigues, B. Lell, A. Deelder, P. Kremsner, M. Yazdanbakhsh (2000)
Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10The Lancet, 356
Y. Yan, G. Inuo, N. Akao, S. Tsukidate, K. Fujita (1997)
Down-regulation of murine susceptibility to cerebral malaria by inoculation with third-stage larvae of the filarial nematode Brugia pahangiParasitology, 114
M. Hesse, C. Piccirillo, Y. Belkaid, Jeannette Prufer, Margaret Mentink-Kane, M. Leusink, A. Cheever, E. Shevach, T. Wynn (2004)
The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T CellsThe Journal of Immunology, 172
S. Till, J. Francis, K. Nouri-Aria, S. Durham (2004)
Mechanisms of immunotherapy.The Journal of allergy and clinical immunology, 113 6
R Hussain (1992)
2731J Immunol, 148
CW Todd (1979)
1440J Immunol, 122
P. Jeannin, Sybille Lecoanet, Y. Delneste, J. Gauchat, J. Bonnefoy (1998)
IgE versus IgG4 production can be differentially regulated by IL-10.Journal of immunology, 160 7
S. Gordon (2003)
Alternative activation of macrophagesNature Reviews Immunology, 3
D. Ledingham, Vivian McAlister, H. Ehigiator, C. Giacomantonio, M. Theal, T. Lee (1996)
Prolongation of rat kidney allograft survival by nematodes.Transplantation, 61 2
M. Kullberg, Edward Pearce, S. Hieny, Alan Sher, J. Berzofsky (1992)
Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.Journal of immunology, 148 10
M. Wilson, R. Maizels (2004)
Regulation of allergy and autoimmunity in helminth infectionClinical Reviews in Allergy & Immunology, 26
P. Matricardi, F. Rosmini, V. Panetta, L. Ferrigno, S. Bonini (2002)
Hay fever and asthma in relation to markers of infection in the United States.The Journal of allergy and clinical immunology, 110 3
R. Summers, D. Elliott, K. Qadir, J. Urban, R. Thompson, J. Weinstock (2003)
Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel diseaseAmerican Journal of Gastroenterology, 98
I. McInnes, B. Leung, M. Harnett, J. Gracie, Fooyew Liew, W. Harnett (2003)
A Novel Therapeutic Approach Targeting Articular Inflammation Using the Filarial Nematode-Derived Phosphorylcholine-Containing Glycoprotein ES-62The Journal of Immunology, 171
Westernized countries are suffering from an epidemic rise in immunologic disorders, such as childhood allergy. A popular explanation is that the increased prevalence in allergy is due to a diminished or altered exposure to gut-dwelling microbes, resulting in a disordered immunoregulation. Various population studies have provided a strong case for the involvement of helminth infections in this respect. Detailed analysis of helminth-induced immune responses showed that helminths not only prime for polarized Th2 responses but also potently induce T-cell hyporesponsiveness. Recently, it has been demonstrated that helminths induce suppressed host immune responses by the priming for regulatory T cells. It is proposed that this regulatory T cell-inducing activity accounts for the protection observed in the development of allergic disorders. It would be interesting to define and characterize particular helminth molecules that have profound immunomodulatory capacities as a target for therapeutic application in the treatment or prophylaxis of allergic manifestations.
Current Allergy and Asthma Reports – Springer Journals
Published: Jan 1, 2005
Keywords: Treg Cell; Allergy Clin Immunol; Cerebral Malaria; Helminth Infection; Schistosoma Mansoni
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.