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Hemostasis
Thirty-three Standardbred foals received a physical examination and had blood drawn for anti-thrombin III (AT III), immunoglobulin G (IgG), and haemostasis evaluation between 24 and 72 h of age. Based on physical examination, a normal haemogram within reference intervals and serum IgG concentration >600 mg/dl, 19 foals remained in the study. AT III values for protein concentration (mg/dl) and activity (mg/dl and percentage thrombin inhibition) were determined by rocket immunoelectrophoresis and chromogenic substrate assay, respectively, and compared to the reference intervals for adults. In 19 healthy, full-term foals, the mean plasma AT III activity for percentage thrombin inhibition (75.9%), mean amount of active AT III (19.2 mg/dl) and the mean plasma AT III concentration (28.7 mg/dl) were significantly (P<0.05) lower than the reference interval of adult values. The mean active AT III concentration for both foals (19.2 mg/dl) and adults (24.6 mg/dl) was significantly (P<0.05) less than their AT III concentration, 28.7 and 44.3 mg/dl, respectively. Fibrinogen degradation products (FDPs) were increased in 100% of the foals, with 12 of 19 (63%) having FDPs >10 <40 μg/dl). Platelet count, prothrombin time, activated partial thromboplastin time and fibrinogen did not differ significantly from those of adult values.
Comparative Clinical Pathology – Springer Journals
Published: Oct 7, 2004
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