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Haematological findings in cats naturally infected with feline immunodeficiency virus

Haematological findings in cats naturally infected with feline immunodeficiency virus The types and prevalence of haematological abnormalities occurring in FIV infected cats were determined. In addition, the role of FIV infection per se in influencing haematological values was examined by analysing results between infected and non-infected cats which had been allocated to similar clinical disease groups. FIV-positive cats were grouped as asymptomatic carriers (AC), cats with AIDS-related complex (ARC) or AIDS. FIV-negative cats were placed into matched groups using the same criteria and designated as healthy, ‘ARC’ or ‘AIDS’. Healthy FIV-negative cats also formed the reference ranges for peripheral blood and bone marrow. Anaemia was no more frequent in sick (‘ARC’ and ‘AIDS’) FIV-positive cats than sick (‘ARC’ and ‘AIDS’) FIV-negative cats. However, it was observed more frequently in FIV-positive cats than FIV-negative cats in the absence of concurrent disease, suggesting a direct effect of FIV infection. Bone marrow was affected by FIV infection; as evidenced by anaemic FIV-positive cats having proportionally less Type I reticulocytes than anaemic FIV-negative cats. In addition, FIV-positive cats demonstrated proportionally fewer mature erythroid cells in their marrow. This implied that FIV may cause a decreased life span or maturation arrest of the erythroid cell line. Lymphopenia and eosinopenia were seen more frequently in AC FIV-positive cats than healthy FIV-negative cats, suggesting the direct involvement of FIV. Thus, although FIV infection affected some haematological findings in AC cats, it appeared that haematological abnormalities in sick FIV-positive cats may be due as much to the disease state as to the virus specifically. Apart from the subjective assessment that bone marrow of FIV-positive cats appeared hypercellular, there were no pathognomonic features for FIV infection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Haematological findings in cats naturally infected with feline immunodeficiency virus

Comparative Clinical Pathology , Volume 6 (2) – Sep 23, 2004

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References (43)

Publisher
Springer Journals
Copyright
Copyright © 1996 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF00426046
Publisher site
See Article on Publisher Site

Abstract

The types and prevalence of haematological abnormalities occurring in FIV infected cats were determined. In addition, the role of FIV infection per se in influencing haematological values was examined by analysing results between infected and non-infected cats which had been allocated to similar clinical disease groups. FIV-positive cats were grouped as asymptomatic carriers (AC), cats with AIDS-related complex (ARC) or AIDS. FIV-negative cats were placed into matched groups using the same criteria and designated as healthy, ‘ARC’ or ‘AIDS’. Healthy FIV-negative cats also formed the reference ranges for peripheral blood and bone marrow. Anaemia was no more frequent in sick (‘ARC’ and ‘AIDS’) FIV-positive cats than sick (‘ARC’ and ‘AIDS’) FIV-negative cats. However, it was observed more frequently in FIV-positive cats than FIV-negative cats in the absence of concurrent disease, suggesting a direct effect of FIV infection. Bone marrow was affected by FIV infection; as evidenced by anaemic FIV-positive cats having proportionally less Type I reticulocytes than anaemic FIV-negative cats. In addition, FIV-positive cats demonstrated proportionally fewer mature erythroid cells in their marrow. This implied that FIV may cause a decreased life span or maturation arrest of the erythroid cell line. Lymphopenia and eosinopenia were seen more frequently in AC FIV-positive cats than healthy FIV-negative cats, suggesting the direct involvement of FIV. Thus, although FIV infection affected some haematological findings in AC cats, it appeared that haematological abnormalities in sick FIV-positive cats may be due as much to the disease state as to the virus specifically. Apart from the subjective assessment that bone marrow of FIV-positive cats appeared hypercellular, there were no pathognomonic features for FIV infection.

Journal

Comparative Clinical PathologySpringer Journals

Published: Sep 23, 2004

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