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Haematological and platelet effects of butylated hydroxytoluene (BHT, E321)

Haematological and platelet effects of butylated hydroxytoluene (BHT, E321) Inclusion of butylated hydroxytoluene (BHT) in the diet of rats, at a dose level of 3 g/kg/day for up to 14 or 21 days, caused modest, but persistent, increases in platelet count, microcytic red blood cell count and red blood cell glutathione (up to 144%, 280% and 197% of control values respectively). These changes were directly BHT-related but unrelated to its hepatotoxicity and independent of vitamin K status. Transient increases in red blood cell count, haematocrit and haemoglobin and transient decreases in reticulocyte, white blood cell and neutrophil counts were, however, related to the early but temporary reduction in food and water intake in the initial stages of feeding the BHT-containing diet. The apparent microcytosis was not accompanied by any other evidence of haemolytic anaemia and may, therefore, have arisen as an artifactual consequence of platelet abnormalities. The cause of the increased platelet phenomenon is not yet characterised but may be an adaptive response to a BHT-related platelet dysfunction and does not appear to be life threatening since an 8-fold increase in mean platelet count has been observed without any detectable adverse effect on thrombogenesis. It is suggested that BHT, given in high doses, could prove to be a useful tool in the identification and characterisation of thrombopoietin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Haematological and platelet effects of butylated hydroxytoluene (BHT, E321)

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Publisher
Springer Journals
Copyright
Copyright © 1994 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF00368276
Publisher site
See Article on Publisher Site

Abstract

Inclusion of butylated hydroxytoluene (BHT) in the diet of rats, at a dose level of 3 g/kg/day for up to 14 or 21 days, caused modest, but persistent, increases in platelet count, microcytic red blood cell count and red blood cell glutathione (up to 144%, 280% and 197% of control values respectively). These changes were directly BHT-related but unrelated to its hepatotoxicity and independent of vitamin K status. Transient increases in red blood cell count, haematocrit and haemoglobin and transient decreases in reticulocyte, white blood cell and neutrophil counts were, however, related to the early but temporary reduction in food and water intake in the initial stages of feeding the BHT-containing diet. The apparent microcytosis was not accompanied by any other evidence of haemolytic anaemia and may, therefore, have arisen as an artifactual consequence of platelet abnormalities. The cause of the increased platelet phenomenon is not yet characterised but may be an adaptive response to a BHT-related platelet dysfunction and does not appear to be life threatening since an 8-fold increase in mean platelet count has been observed without any detectable adverse effect on thrombogenesis. It is suggested that BHT, given in high doses, could prove to be a useful tool in the identification and characterisation of thrombopoietin.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Sep 8, 2004

References

  • Thrombopoietin production in mice treated with acetylsalicylic acid
    Clift, RE; Cottrell, MB; McDonald, TP
  • Evaluation of erythropoiesis after bone marrow transplantation: quantitative reticulocyte counting
    Davies, SV; Cavill, I; Bentley, N
  • Microdetermination of oxyhaemoglobin, methaemoglobin and sulphaemoglobin in a single sample of blood
    Evelyn, KA; Malloy, HT
  • A fluorometric method for determination of oxidised and reduced glutathione in tissues
    Hissin, PJ; Hilf, R
  • Evidence that stimulation of megakaryocytopoiesis by low dose vincristine results from an effect on platelets
    Jackson, CW; Edwards, CC
  • A comparative study of platelet aggregation in man and laboratory animal
    MacMillan, DC; Sim, AK
  • Effect of starvation and refeeding on the circadian rhythms of hematological and clinico-biochemical values, and water intake of rats
    Maejima, K; Nagase, S
  • Regulation of megakaryocytopoiesis by thrombopoietin
    McDonald, TP
  • Adaptation of coenzyme stimulation assays for the nutritional assessment of vitamins B1, B2 and B6 using the Cobas Bio centrifugal analyser
    Mount, JN; Heduan, E; Herd, C
  • Hepatotoxicity of butylated hydroxytoluene (BHT) to rats
    Nakagawa, Y; Tayama, K; Hiraga, K
  • Hepatic responses to the administration of high doses of BHT to the rat: their relevance to hepatocarcinogenicity
    Powell, CJ; Connelly, JC; Jones, SM
  • Acetylsalicylic acid stimulates murine megakaryocyte precursor cells
    Sullivan, PS; McDonald, TP
  • Reduced aggregation capacity of washed platelets and dysfibrinogenaemia in rats given butylated hydroxytoluene
    Takahashi, O
  • Feeding of butylated hydroxytoluene to rats caused a rapid decrease in blood coagulation factors II (prothrombin), VII, IX and X
    Takahashi, O
  • Some properties of rat platelet aggregation and effects of butylated hydroxytoluene, warfarin and aspirin
    Takahashi, O
  • Effects of dietary butylated hydroxytoluene on functional and biochemical properties of platelets and plasma preceding the occurrence of haemorrhage
    Takahashi, O; Hiraga, K
  • Significance of reduced food and water consumption in rats intoxicated with vanadium
    Zaporowska, H; Wasilewski, W