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J. Elfenbein, S. Robertson, R. MacKay, B. Kukanich, L. Sanchez (2014)
Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horsesBMC Veterinary Research, 10
G. Taccetti, S. Campana, A. Neri, V. Boni, F. Festini (2008)
Antibiotic Therapy against Pseudomonas aeruginosa in Cystic FibrosisJournal of Chemotherapy, 20
A. Farid, Y. Horii (2012)
Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosisLipids in Health and Disease, 11
K. Poole (2011)
Pseudomonas Aeruginosa: Resistance to the MaxFrontiers in Microbiology, 2
David Bass, T. Gonwa, P. Szejda, M. Cousart, L. Dechatelet, C. McCall (1980)
Eosinopenia of acute infection: Production of eosinopenia by chemotactic factors of acute inflammation.The Journal of clinical investigation, 65 6
D. Boothe, A. Boeckh, H. Boothe (2009)
Evaluation of the distribution of enrofloxacin by circulating leukocytes to sites of inflammation in dogs.American journal of veterinary research, 70 1
Stefanie Linch, Ann Kelly, Erin Danielson, R. Pero, James Lee, J. Gold (2009)
Mouse Eosinophils Possess Potent Antibacterial Properties In VivoInfection and Immunity, 77
M. Leendertse, R. Willems, Ida Giebelen, P. Pangaart, M. Bonten, T. Poll (2009)
The acute‐phase response impairs host defence against Enterococcus faecium peritonitisImmunology, 128
M. Thrall (2003)
Veterinary Hematology and Clinical Chemistry
B Tras, A Maden, L Bas, M Elmas, E Yazar, T Civelek (2001)
Investigation of biochemical side-effects on enrofloxacin in dogsJ Vet Med A, 48
I. Infusino, M. Panteghini (2013)
Serum albumin: accuracy and clinical use.Clinica chimica acta; international journal of clinical chemistry, 419
Y Morita, J Tomida, Y Kawamura (2014)
Responses of Pseudomonas aeruginosa to antimicrobials—reviewFront Microbiol Antimicrob Resist Chemotherapy, 4
G. Rossi, A. Giordano, F. Pezzia, M. Kjelgaard‐Hansen, S. Paltrinieri (2013)
Serum paraoxonase 1 activity in dogs: preanalytical and analytical factors and correlation with C-reactive protein and alpha-2-globulin.Veterinary clinical pathology, 42 3
(2000)
Acute phase protein in different species measured as a tool to assess animal health
B. Bardoel, Elaine Kenny, G. Sollberger, A. Zychlinsky (2014)
The balancing act of neutrophils.Cell host & microbe, 15 5
M. Vitiello, M. Galdiero, E. Finamore, S. Galdiero, M. Galdiero (2012)
NF-κB as a potential therapeutic target in microbial diseases.Molecular bioSystems, 8 4
M. Salman, Chandramouli Malleda, Narayanavari Suneel, I. Qureshi, E. Frank, C. D'Souza (2011)
Homology modeling of human serum paraoxonase1 and its molecular interaction studies with aspirin and cefazolinBioinformation, 7
M. Andonova, V. Urumova, B. Petkova, E. Slavov, P. Dzhelebov, T. Chaprazov, R. Roydev, I. Borissov (2014)
Haematological and biochemical parameters characterising the progression of experimental Pseudomonas aeruginosa skin infection in dogs.Bulgarian Journal of Veterinary Medicine, 17
A. Toker, M. Kadı, A. Yıldırım, H. Aksoy, F. Akçay (2009)
Serum lipid profile paraoxonase and arylesterase activities in psoriasisCell Biochemistry and Function, 27
C. Mavroudis, C. Backer, R. Idriss (1994)
Pediatric Cardiac Surgery
K. Lorentz, B. Flatter, E. Augustin (1979)
Arylesterase in serum: elaboration and clinical application of a fixed-incubation method.Clinical chemistry, 25 10
Christine Juliana, T. Fernandes‐Alnemri, Jianghong Wu, P. Datta, L. Solórzano, Je-Wook Yu, R. Meng, A. Quong, E. Latz, C. Scott, E. Alnemri (2010)
Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome*The Journal of Biological Chemistry, 285
M. Andonova, V. Urumova (2013)
Immune surveillance mechanisms of the skin against the stealth infection strategy of Pseudomonas aeruginosa-review.Comparative immunology, microbiology and infectious diseases, 36 5
J. Cerón, F. Tecles, A. Tvarijonaviciute (2014)
Serum paraoxonase 1 (PON1) measurement: an updateBMC Veterinary Research, 10
V. Kumar, G. Chandra, J. Ramesh, S. Vairamuthu, P. Thejomoorthy, P. Hariharan (2012)
Effect of enrofloxacin administration on haematological profile in broiler chicken- A safety pharmacology studyIndian Journal of Field Veterinarians, 8
J. Boehmer, Z. Olumee-Shabon (2018)
Acute phase proteins : Biomarkers of infection and inflammation in food animals
D. Farrell (2004)
Pathophysiologic roles of the fibrinogen gamma chainCurrent Opinion in Hematology, 11
T. Georgieva, I. Georgiev, S. Tanev, A. Vachkov, V. Petrov, P. Eckersall, L. Sotirov, L. Lazarov, T. Christov, J. Nikolov (2009)
Variations of acute phase protein (haptoglobin, fibrinogen and ceruloplasmin) concentrations in weaning rabbits after experimental infection with E.coliRevue De Medecine Veterinaire, 160
J. Cerón, P. Eckersall, Silvia Martýnez-Subiela (2005)
Acute phase proteins in dogs and cats: current knowledge and future perspectives.Veterinary clinical pathology, 34 2
TM Georgieva, IP Georgiev, VS Petrov, A Vachkov, SI Tanev, AI Pavlov, D Eskersall (2009)
Variations of acute phase proteins in weaning rabbits experimentally infected with E. coliRev Med Vet, 160
V. George, P. Suresh, R. Ashok (2012)
A REVIEW ON THE THERAPEUT IC POTENTIALS OF PARTHENOLIDE: A SESQUITERPENE LACTONE
PD Eckersall, F Bell (2010)
Acute phase proteins: biomarkers of infection and inflammationVet J, 185
M. Oran, F. Tulubas, R. Mete, M. Aydın, Hatice Sarıkaya, A. Gurel (2014)
Evaluation of paraoxonase and arylesterase activities in patients with irritable bowel syndrome.JPMA. The Journal of the Pakistan Medical Association, 64 7
A. Tvarijonaviciute, M. Kocaturk, M. Cansev, F. Tecles, J. Cerón, Z. Yilmaz (2012)
Serum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: effects of choline administration.Research in veterinary science, 93 2
(2014)
Antibiotic resistance—the need for global solutionsBDJ, 216
S. Kroemer, F. Garch, D. Galland, J. Petit, F. Woehrlé, H. Boulouis (2014)
Antibiotic susceptibility of bacteria isolated from infections in cats and dogs throughout Europe (2002-2009).Comparative immunology, microbiology and infectious diseases, 37 2
A. Gregory, Lisa Hogue, T. Ferkol, D. Link (2004)
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.Blood, 109 8
M. Hayden, A. West, S. Ghosh (2006)
NF-kappaB and the immune response.Oncogene, 25 51
B. Tras, M. Maden, A. Bas, M. Elmas, E. Yazar, T. Ci̇velek (2001)
Investigation of biochemical and haematological side-effects of enrofloxacin in dogs.Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 48 1
P. Eckersall, R. Bell (2010)
Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine.Veterinary journal, 185 1
Y. Morita, J. Tomida, Y. Kawamura (2014)
Responses of Pseudomonas aeruginosa to antimicrobialsFrontiers in Microbiology, 4
J. Camps, I. Pujol, F. Ballester, J. Joven, J. Simó (2011)
Paraoxonases as Potential Antibiofilm Agents: Their Relationship with Quorum-Sensing Signals in Gram-Negative BacteriaAntimicrobial Agents and Chemotherapy, 55
Changes in white blood cells, leukogram patterns, the positive acute-phase protein (APP) fibrinogen and negative APPs (albumin and arylesterase) were monitored to evaluate their potential as sensitive indicators throughout the course of therapy in canine skin Pseudomonas aeruginosa infection. The study was performed on 15 male mixed-breed dogs, divided in three groups of 5 dogs each. Dogs from group A were injected subcutaneously with P. aeruginosa bacterial culture (1 × 108 CFU/mL) at a dose of 0.3 mL/kg and treated with enrofloxacin (5 mg/kg, s.c.) on post infection hour 48 for 10 consecutive days. Dogs from group B were infected and treated with a combination of enrofloxacin (at above-mentioned dose and intervals) and parthenolide (feverfew extract 90 mg, 0.7 % parthenolide). The schedule consisted of daily oral intake of two capsules of feverfew beginning on post infection hour 4 and continued for 6 days. The control group C included healthy dogs, injected s.c. with 0.3 mL/kg physiological saline. The haematological indices and APPs were assayed before infection and on 4th, 24th, 48th and 72nd hours and on 7th, 10th and 14th days after infection. Infected and antibiotic-treated dogs responded with significant leukocytosis, left shift, eosinopaenia and lymphopaenia between hours 24 and 72. In this group, fibrinogen increased substantially by post infection hours 24 (p < 0.01 vs 0 h; p < 0.05 vs group C), 48 (p < 0.001 vs 0 h; p < 0.05 vs group C) and 72 (p < 0.001 vs 0 h; p < 0.01 vs group C) while albumin reduction was marked by hours 48 (p < 0.05 vs 0 h) and 72 (p < 0.05 vs 0 h; p < 0.001 vs group C) and day 7 (p < 0.01 vs 0 h; p < 0.001 vs group C). The combination of enrofloxacin and parthenolide modified, at a significant extent, the deviations in studied parameters except for eosinophil percentage, which persisted low.
Comparative Clinical Pathology – Springer Journals
Published: Feb 22, 2016
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