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Giant cell-rich osteosarcoma of tibia in a dog: a pathological and immunohistochemical study

Giant cell-rich osteosarcoma of tibia in a dog: a pathological and immunohistochemical study Osteosarcoma is determined as a bone matrix-producing malignant mesenchymal tumor. However, it is relatively rare among different species of domestic animals, but it corresponds about 85 % of all malignant bone tumors in dogs. Nevertheless, the giant cell-rich osteosarcoma (GCRO) is a rare subtype of the osteosarcoma, which to our knowledge has not yet been reported in dogs. This report describes a GCRO in the tibia of a six and half-year-old, spayed, 41 kg, female, Scottish deerhound dog with a history of a mass on the tibia and severe lameness being observed by the owner. Histologically, the tumor was characterized by numerous multinucleated giant cell nests separated by small bundles of pleomorphic to polygonal cells. Between the spindle cells, osteoid was rare and organized in thin strands. Immunohistochemical stains for vimentin were positive, with no detectable cellular staining for cytokeratin. A GCRO was concluded in this case. The dog died 1 week after the biopsy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Giant cell-rich osteosarcoma of tibia in a dog: a pathological and immunohistochemical study

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References (17)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer-Verlag London
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-014-1892-z
Publisher site
See Article on Publisher Site

Abstract

Osteosarcoma is determined as a bone matrix-producing malignant mesenchymal tumor. However, it is relatively rare among different species of domestic animals, but it corresponds about 85 % of all malignant bone tumors in dogs. Nevertheless, the giant cell-rich osteosarcoma (GCRO) is a rare subtype of the osteosarcoma, which to our knowledge has not yet been reported in dogs. This report describes a GCRO in the tibia of a six and half-year-old, spayed, 41 kg, female, Scottish deerhound dog with a history of a mass on the tibia and severe lameness being observed by the owner. Histologically, the tumor was characterized by numerous multinucleated giant cell nests separated by small bundles of pleomorphic to polygonal cells. Between the spindle cells, osteoid was rare and organized in thin strands. Immunohistochemical stains for vimentin were positive, with no detectable cellular staining for cytokeratin. A GCRO was concluded in this case. The dog died 1 week after the biopsy.

Journal

Comparative Clinical PathologySpringer Journals

Published: Feb 13, 2014

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