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Genetic Counseling and Genetic Testing in the Preoperative Evaluation of Breast Cancer Patients

Genetic Counseling and Genetic Testing in the Preoperative Evaluation of Breast Cancer Patients Breast cancers arising in the context of germline BRCA gene mutation have unique biological features that must be considered during treatment planning. Breast conserving surgery is an acceptable option in highly motivated women who are fully informed about the risks of ipsilateral breast tumor recurrence and contralateral breast cancer. Partial breast irradiation is not recommended for these women. Concurrent bilateral salpingo-oophorectomy should be considered. BRCA1-associated breast cancer may be resistant to taxanes, but appears highly sensitive to platinum agents and to PARP inhibitors. Preoperative genetic testing can be accomplished with short turn around times and does not increase patient anxiety. Inclusion of a professional genetic counselor in the management team is essential. BRCA gene mutation status is emerging as an important prognostic and predictive factor for breast cancer patients. Preoperative genetic counseling and testing is recommended for women likely to carry a BRCA gene mutation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Breast Cancer Reports Springer Journals

Genetic Counseling and Genetic Testing in the Preoperative Evaluation of Breast Cancer Patients

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Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Internal Medicine; Surgical Oncology; Oncology
ISSN
1943-4588
eISSN
1943-4596
DOI
10.1007/s12609-012-0071-y
Publisher site
See Article on Publisher Site

Abstract

Breast cancers arising in the context of germline BRCA gene mutation have unique biological features that must be considered during treatment planning. Breast conserving surgery is an acceptable option in highly motivated women who are fully informed about the risks of ipsilateral breast tumor recurrence and contralateral breast cancer. Partial breast irradiation is not recommended for these women. Concurrent bilateral salpingo-oophorectomy should be considered. BRCA1-associated breast cancer may be resistant to taxanes, but appears highly sensitive to platinum agents and to PARP inhibitors. Preoperative genetic testing can be accomplished with short turn around times and does not increase patient anxiety. Inclusion of a professional genetic counselor in the management team is essential. BRCA gene mutation status is emerging as an important prognostic and predictive factor for breast cancer patients. Preoperative genetic counseling and testing is recommended for women likely to carry a BRCA gene mutation.

Journal

Current Breast Cancer ReportsSpringer Journals

Published: Feb 11, 2012

References