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Generation of Induced Wavefront Focalization in the Human Temporal Bone Using a Standard Focused Ultrasound Single-Element Transducer

Generation of Induced Wavefront Focalization in the Human Temporal Bone Using a Standard Focused... PurposeFocused ultrasound (FUS) has been studied extensively in the medical field for tissue ablation, neuromodulation, and medication administration. The present proposal investigates the influence of frequency and skull geometry on acoustic transmission through the human temporal fossa by using single-element immersion ultrasound transducers to verify the acoustic map pressure generated by the deformation of acoustic waves.MethodsA needle-type hydrophone with a 1-mm tip attached to a computed guided 3D axis system was used to characterize the aberrations induced by a human skull in a water tank. A planar ultrasound transducer with a central frequency of 0.4 MHz and a focused transducer with a central frequency of 1.7 MHz, both targeting the beam through the human temporal bone, was used to create the acoustic pressure profile maps.ResultsThe results show that by focusing acoustic waves in the temporal bone, a planar transducer can be focalized by passing through the skull, creating a maximum focal pressure of 236.1 kPa, and a focused ultrasound transducer with a higher central frequency than those reported in the literature for human neurostimulation protocols can generate an acoustic map with a maximum focal pressure of 24.1 kPa.ConclusionThese experiments have demonstrated that the skull behaves as an acoustic lens, concentrating and attenuating the acoustic beam as it passes through. This study also proposes that a single-element focused ultrasound transducer with a center frequency of 1.7 MHz may be useful for non-invasive transcranial ultrasound applications. This finding could improve the effectiveness of transcranial ultrasound applications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Biomedical Engineering Springer Journals

Generation of Induced Wavefront Focalization in the Human Temporal Bone Using a Standard Focused Ultrasound Single-Element Transducer

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References (27)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to The Brazilian Society of Biomedical Engineering 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
2446-4732
eISSN
2446-4740
DOI
10.1007/s42600-023-00313-8
Publisher site
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Abstract

PurposeFocused ultrasound (FUS) has been studied extensively in the medical field for tissue ablation, neuromodulation, and medication administration. The present proposal investigates the influence of frequency and skull geometry on acoustic transmission through the human temporal fossa by using single-element immersion ultrasound transducers to verify the acoustic map pressure generated by the deformation of acoustic waves.MethodsA needle-type hydrophone with a 1-mm tip attached to a computed guided 3D axis system was used to characterize the aberrations induced by a human skull in a water tank. A planar ultrasound transducer with a central frequency of 0.4 MHz and a focused transducer with a central frequency of 1.7 MHz, both targeting the beam through the human temporal bone, was used to create the acoustic pressure profile maps.ResultsThe results show that by focusing acoustic waves in the temporal bone, a planar transducer can be focalized by passing through the skull, creating a maximum focal pressure of 236.1 kPa, and a focused ultrasound transducer with a higher central frequency than those reported in the literature for human neurostimulation protocols can generate an acoustic map with a maximum focal pressure of 24.1 kPa.ConclusionThese experiments have demonstrated that the skull behaves as an acoustic lens, concentrating and attenuating the acoustic beam as it passes through. This study also proposes that a single-element focused ultrasound transducer with a center frequency of 1.7 MHz may be useful for non-invasive transcranial ultrasound applications. This finding could improve the effectiveness of transcranial ultrasound applications.

Journal

Research on Biomedical Engineering – Springer Journals

Published: Sep 19, 2023

Keywords: Focused beam; Neuromodulation; Processing signals; Ultrasound transducers

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