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Generalized muscular steatosis (pseudohypertrophy) in a heifer

Generalized muscular steatosis (pseudohypertrophy) in a heifer Although multiple hypotheses have been proposed for the pathogenesis of muscular steatosis (pseudohypertrophy), the published evidence that supports either of these hypotheses is limited. A 14-month-old Holstein–Friesian heifer, which was slaughtered 2 days after the onset of dyspnea, hypotonia, hindquarter weakness, and ultimate inability to rise, showed bilateral lesions of muscular steatosis involving almost all skeletal muscles including the diaphragm. Lesions were characterized primarily by widespread replacement of myofibers by adipose tissue, which occurred more preferentially at the areas adjacent to the perimysial connective tissue. Atrophic or degenerated myofibers were present more prominently at the marginal areas of the muscle fascicles. Many perimysial arterioles showed fibrinoid degeneration systematically. It is thought that ischemia due to systematic arteriolar alteration was implicated in the development of this spontaneously occurring generalized muscular steatosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Generalized muscular steatosis (pseudohypertrophy) in a heifer

Ohfuji, S.
Comparative Clinical Pathology , Volume 22 (4) – Mar 13, 2013
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Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer-Verlag London
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-013-1723-7
Publisher site
See Article on Publisher Site

Abstract

Although multiple hypotheses have been proposed for the pathogenesis of muscular steatosis (pseudohypertrophy), the published evidence that supports either of these hypotheses is limited. A 14-month-old Holstein–Friesian heifer, which was slaughtered 2 days after the onset of dyspnea, hypotonia, hindquarter weakness, and ultimate inability to rise, showed bilateral lesions of muscular steatosis involving almost all skeletal muscles including the diaphragm. Lesions were characterized primarily by widespread replacement of myofibers by adipose tissue, which occurred more preferentially at the areas adjacent to the perimysial connective tissue. Atrophic or degenerated myofibers were present more prominently at the marginal areas of the muscle fascicles. Many perimysial arterioles showed fibrinoid degeneration systematically. It is thought that ischemia due to systematic arteriolar alteration was implicated in the development of this spontaneously occurring generalized muscular steatosis.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Mar 13, 2013

References

  • Disorders of voluntary muscle
    Bradley, R; Fell, BF
  • Polymyositis and dermatomyositis
    Dalakas, MC; Hohlfeld, R
  • Microvascular changes in early and advanced dermatomyositis: a quantitative study
    Emslie-Smith, AM; Engel, AG
  • Microvascular changes in skeletal muscle in idiopathic inflammatory myopathy
    Estruch, R; Grau, JM; Fernández-Solá, J; Casadmont, J; Monforte, R; Urbano-Márquez, A
  • Inflammatory myopathies: evaluation and management
    Greenberg, SA
  • Diseases of skeletal muscle. Comparative neuropathology
    Hadlow, WJ
  • Animal experiment and biopsy studies on the cause, manifestations and diagnostic relevance of perifascicular muscle fiber atrophy
    Herrmann, V
  • Muscular pseudohypertrophy (steatosis) in a bovine fetus
    Langohr, IM; Stevenson, GW; Valentine, BA
  • Muscular pseudohypertrophy in an adult case with centronuclear myopathy
    Matsushita, S; Ikeda, S; Hanyu, N; Yamamoto, K; Yanagisawa, N
  • Thomson’s special veterinary pathology
    McGavin, MD
  • Atlas of meat inspection pathology
    Monlux, WS; Monlux, AW
  • Vascular pathology in dermatomyositis and anatomic relations to myopathology
    Pestronk, A; Schmidt, RE; Choksi, R
  • Developmental disorders of skeletal muscle in cattle, pigs and sheep
    Swatland, HJ