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Curr Allergy Asthma Rep (2017) 17: 8 DOI 10.1007/s11882-017-0672-7 ALLERGENS (RK BUSH AND JA WOODFOLK, SECTION EDITORS) Galactose-α-1,3-Galactose: Atypical Food Allergen or Model IgE Hypersensitivity? 1 1 1 Jeffrey M. Wilson & Alexander J. Schuyler & Nikhila Schroeder & Thomas A. E. Platts-Mills Published online: 21 February 2017 Springer Science+Business Media New York 2017 . . Abstract Keywords Alpha-gal (α-gal) Food allergy Red meat . . Purpose of Review Galactose-α-1,3-galactose (α-gal) is a car- allergy Th2 Type 2 immunity bohydrate allergen with several unique characteristics. In this article, we discuss some recent advances in our understanding of the ‘alpha-gal syndrome,’ highlight data supporting the role Introduction of ticks in pathogenesis, and speculate on immune mecha- nisms that lead to sensitization. Until recently, the oligosaccharide galactose-α-1,3-galactose Recent Findings First described as the target of IgE in indi- (α-gal) was best known for its role as a major antigenic barrier viduals suffering immediate hypersensitivity reactions to the in xenotransplantation [1]. Owing to a loss of functional 1,3 novel anti-EGF monoclonal antibody cetuximab, it is now galactosyltransferase, humans and other members of the cat- clear that α-gal sensitization is associated with mammalian arrhine group of primates lack the synthetic machinery to gen-
Current Allergy and Asthma Reports – Springer Journals
Published: Feb 21, 2017
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