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Functional competence and monoclonal antibody reactivity of neutrophils from cows injected with Escherichia coli endotoxin

Functional competence and monoclonal antibody reactivity of neutrophils from cows injected with... Neutrophils of cows injected with endotoxin were evaluated for their functional competence and monoclonal antibody binding in relation to morphological maturity. Six clinically healthy lactating Holstein cows were each injected intravenously with 100 μg Escherichia coli endotoxin. Blood was collected at 0, 6, 30, 54, 78 and 150 hours postinjection for total and differential leucocyte counts and to isolate neutrophils for functional assays. Marked leucopenia, neutropenia with left shift to band neutrophils, lymphopenia and monocytopenia were evident at 6 h postinjection. Neutrophil and lymphocyte counts normalised by 30 hours, while band neutrophils remained elevated until 54 hours postinjection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Functional competence and monoclonal antibody reactivity of neutrophils from cows injected with Escherichia coli endotoxin

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References (71)

Publisher
Springer Journals
Copyright
Copyright © 1991 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF00422688
Publisher site
See Article on Publisher Site

Abstract

Neutrophils of cows injected with endotoxin were evaluated for their functional competence and monoclonal antibody binding in relation to morphological maturity. Six clinically healthy lactating Holstein cows were each injected intravenously with 100 μg Escherichia coli endotoxin. Blood was collected at 0, 6, 30, 54, 78 and 150 hours postinjection for total and differential leucocyte counts and to isolate neutrophils for functional assays. Marked leucopenia, neutropenia with left shift to band neutrophils, lymphopenia and monocytopenia were evident at 6 h postinjection. Neutrophil and lymphocyte counts normalised by 30 hours, while band neutrophils remained elevated until 54 hours postinjection.

Journal

Comparative Clinical PathologySpringer Journals

Published: Sep 22, 2004

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