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Forming vascular networks within functional cardiac tissue constructs

Forming vascular networks within functional cardiac tissue constructs Over the years much has been attempted to generate engineered cardiac tissue. One approach is culturing cells within engineered biodegradable scaffolds to provide temporary elastic support and to replace the necrotic cardiomyocytes. In particular, these engineered tissue construct have been of great interest as an implantable patch over a region of the myocardial infarct to stimulate the formation of micro-vessel growth and thus increase blood flow through the myocardium. For the successful revascularization after myocardial infarction, vascularization within three-dimensional engineered cardiac tissue construct has become important for stimulating the formation of a mature microvascular network. In this review, various approaches and recent advances in vascularization of engineered cardiac patch are highlighted and discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biomedical Engineering Letters Springer Journals

Forming vascular networks within functional cardiac tissue constructs

Lee, Hanna; Bae, Hojae
Biomedical Engineering Letters , Volume 3 (3) – Oct 9, 2013
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References (59)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Korean Society of Medical and Biological Engineering and Springer
Subject
Engineering; Biomedical Engineering; Biophysics and Biological Physics; Biomedicine general; Medical and Radiation Physics
ISSN
2093-9868
eISSN
2093-985X
DOI
10.1007/s13534-013-0106-y
Publisher site
See Article on Publisher Site

Abstract

Over the years much has been attempted to generate engineered cardiac tissue. One approach is culturing cells within engineered biodegradable scaffolds to provide temporary elastic support and to replace the necrotic cardiomyocytes. In particular, these engineered tissue construct have been of great interest as an implantable patch over a region of the myocardial infarct to stimulate the formation of micro-vessel growth and thus increase blood flow through the myocardium. For the successful revascularization after myocardial infarction, vascularization within three-dimensional engineered cardiac tissue construct has become important for stimulating the formation of a mature microvascular network. In this review, various approaches and recent advances in vascularization of engineered cardiac patch are highlighted and discussed.

Journal

Biomedical Engineering Letters – Springer Journals

Published: Oct 9, 2013

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