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Food protein-induced enterocolitis syndrome: a review of the new guidelines

Food protein-induced enterocolitis syndrome: a review of the new guidelines Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated gastrointestinal food allergy that presents with delayed vomiting after ingestion primarily in infants. While the pathophysiology of FPIES is poorly understood, the clinical presentation of acute FPEIS reactions has been well characterized. The first International Consensus Guidelines for the Diagnosis and Management of Food Protein–induced Enterocolitis Syndrome were published in 2017 and reviewed epidemiology, clinical presentation, and prognosis of acute and chronic FPIES. The workgroup outlined clinical phenotypes, proposed diagnostic criteria, and made recommendations on management. This article summarizes the guidelines and adds recent updates. FPIES is gaining recognition, however there continues to be delays in diagnosis and misdiagnosis due to overlap of symptoms with over conditions, lack of a diagnostic test, and because some of the common trigger foods are not thought of as allergenic. More research into disease mechanisms and factors influencing differences between populations is needed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Allergy Organization Journal Springer Journals

Food protein-induced enterocolitis syndrome: a review of the new guidelines

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Publisher
Springer Journals
Copyright
Copyright © 2018 by The Author(s).
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
1939-4551
DOI
10.1186/s40413-017-0182-z
Publisher site
See Article on Publisher Site

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated gastrointestinal food allergy that presents with delayed vomiting after ingestion primarily in infants. While the pathophysiology of FPIES is poorly understood, the clinical presentation of acute FPEIS reactions has been well characterized. The first International Consensus Guidelines for the Diagnosis and Management of Food Protein–induced Enterocolitis Syndrome were published in 2017 and reviewed epidemiology, clinical presentation, and prognosis of acute and chronic FPIES. The workgroup outlined clinical phenotypes, proposed diagnostic criteria, and made recommendations on management. This article summarizes the guidelines and adds recent updates. FPIES is gaining recognition, however there continues to be delays in diagnosis and misdiagnosis due to overlap of symptoms with over conditions, lack of a diagnostic test, and because some of the common trigger foods are not thought of as allergenic. More research into disease mechanisms and factors influencing differences between populations is needed.

Journal

World Allergy Organization Journal – Springer Journals

Published: Feb 7, 2018

References

  • Food protein-induced enterocolitis syndrome: insights from review of a large referral population
    Ruffner, MA; Ruymann, K; Barni, S; Cianferoni, A; Brown-Whitehorn, T; Spergel, JM
  • Clinical and immunological characteristics of a pediatric population with food protein-induced enterocolitis syndrome (FPIES) to fish
    Gonzalez-Delgado, P; Caparros, E; Moreno, MV
  • Humoral and cellular responses to casein in patients with food protein-induced enterocolitis to cow's milk
    Caubet, JC; Bencharitiwong, R; Ross, A; Sampson, HA; Berin, MC; Nowak-Wegrzyn, A
  • Clinical features and resolution of food protein-induced enterocolitis syndrome: 10-year experience
    Caubet, JC; Ford, LS; Sickles, L
  • Unusual shift from IgE-mediated milk allergy to food protein-induced enterocolitis syndrome
    Banzato, C; Piacentini, GL; Comberiati, P; Mazzei, F; Boner, AL; Peroni, DG
  • Use of ondansetron for food protein-induced enterocolitis syndrome
    Holbrook, T; Keet, CA; Frischmeyer-Guerrerio, PA; Wood, RA
  • Ondansetron for food protein-induced enterocolitis syndrome
    Miceli Sopo, S; Battista, A; Greco, M; Monaco, S