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- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Springer London
- Subject
- Medicine & Public Health; Oncology ; Hematology; Pathology
- eISSN
- 1618-565X
- DOI
- 10.1007/s00580-008-0721-7
- Publisher site
- See Article on Publisher Site
Abstract
The fibrinolytic mechanism in the armadillo Chaetophractus villosus (Mammalia, Xenarthra, Dasypodidae) quite unknown until now was studied. Results were compared with those corresponding to healthy adult human beings. Whole blood lysis time and diluted blood lysis time were not detectable in armadillos. Euglobulin clot lysis time and plasminogen activity (Plg) were lower than in healthy humans. We established the presence of the fibrinolytic system in Ch. villosus through the measurement of fibrin fibrinogen degradation products. The activity of the plasminogen activator inhibitor was two to four times greater than in healthy humans. The activity of the alpha 2 anti-plasmin (α2AP) was similar and displaced toward lower values. The Plg/α2AP relation was lower. The results obtained suggest that Ch. villosus has a hypercoagulable and hypofibrinolytic profile. Our findings are not only the first contribution to elucidate the physiology of the fibrinolytic system in Xenarthra but also contribute to develop an animal model for studies in haemostasis and thrombosis.
Journal
Comparative Clinical Pathology – Springer Journals
Published: Mar 5, 2008