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K. Satoh, Y. Fukumoto, M. Nakano, K. Sugimura, J. Nawata, J. Demachi, A. Karibe, Y. Kagaya, N. Ishii, K. Sugamura, H. Shimokawa (2009)
Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1.Cardiovascular research, 81 1
C. Peclet, G. Lamirande, R. Daoust (1982)
Sensitivity to RNase treatment of ribosomes and rRNA from normal rat liver and Novikoff hepatoma.British Journal of Cancer, 45
K. Birnbaum, D.C. Wirtz, C.H. Siebert (2002)
Use of extracorporeal shock-wave therapy (ESWT) in the treatment of non-unions: a review of the literatureArch Orthop Trauma Surg, 122
S. Silver (1937)
Heart FailureThe Indian Medical Gazette, 72
C. Prinz, O. Lindner, T. Bitter, D. Hering, W. Burchert, D. Horstkotte, L. Faber (2009)
Extracorporeal Cardiac Shock Wave Therapy Ameliorates Clinical Symptoms and Improves Regional Myocardial Blood Flow in a Patient with Severe Coronary Artery Disease and Refractory AnginaCase Reports in Medicine, 2009
E. Martin‐Rendon, S. Brunskill, C. Hyde, S. Stanworth, A. Mathur, S. Watt (2008)
Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review.European heart journal, 29 15
Daniel Ceradini, Anita Kulkarni, M. Callaghan, Oren Tepper, N. Bastidas, M. Kleinman, Jennifer Capla, R. Galiano, J. Levine, G. Gurtner (2004)
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1Nature Medicine, 10
M. Seidl, P. Steinbach, K. Wörle, F. Hofstädter (1994)
Induction of stress fibres and intercellular gaps in human vascular endothelium by shock-waves.Ultrasonics, 32 5
Y. Kikuchi, K. Ito, Yoshitaka Ito, T. Shiroto, R. Tsuburaya, K. Aizawa, K. Hao, Y. Fukumoto, J. Takahashi, M. Takeda, M. Nakayama, S. Yasuda, S. Kuriyama, I. Tsuji, H. Shimokawa (2010)
Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris.Circulation journal : official journal of the Japanese Circulation Society, 74 3
A. Aicher, C. Heeschen, Ken-ichiro Sasaki, C. Urbich, A. Zeiher, S. Dimmeler (2006)
Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells: A New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb IschemiaCirculation, 114
D. Nurzynska, F. Meglio, C. Castaldo, A. Arcucci, E. Marlinghaus, S. Russo, B. Corrado, L. Santo, F. Baldascino, M. Cotrufo, S. Montagnani (2008)
Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart.Ultrasound in medicine & biology, 34 2
K. Wollert, G. Meyer, J. Lotz, Stefanie Lichtenberg, P. Lippolt, C. Breidenbach, S. Fichtner, T. Korte, B. Hornig, D. Messinger, L. Arseniev, B. Hertenstein, A. Ganser, H. Drexler (2004)
Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trialThe Lancet, 364
R. Saggini, A. Figus, A. Troccola, V. Cocco, A. Saggini, N. Scuderi (2008)
Extracorporeal shock wave therapy for management of chronic ulcers in the lower extremities.Ultrasound in medicine & biology, 34 8
A. Volpi, C. Vita, M.G. Franzosi (1993)
Determinants of 6-month mortality in survivors of myocardial infarction after thrombolysis: results of the GISSI-2 data base. The Ad hoc Working Group of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-2 Data BaseCirculation, 88
A. Khattab, Broder Brodersen, Daniela Schuermann-Kuchenbrandt, H. Beurich, R. Tölg, V. Geist, T. Schäfer, G. Richardt (2007)
Extracorporeal cardiac shock wave therapy: first experience in the everyday practice for treatment of chronic refractory angina pectoris.International journal of cardiology, 121 1
E. Maisonhaute, César Prado, P. White, R. Compton (2002)
Surface acoustic cavitation understood via nanosecond electrochemistry. Part III: Shear stress in ultrasonic cleaning.Ultrasonics sonochemistry, 9 6
Arman Askari, S. Unzek, Z. Popović, C. Goldman, F. Forudi, M. Kiedrowski, A. Rovner, S. Ellis, James Thomas, P. Dicorleto, E. Topol, M. Penn (2003)
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathyThe Lancet, 362
T. Uwatoku, K. Ito, K. Abe, K. Oi, Takatoshi Hizume, K. Sunagawa, H. Shimokawa (2007)
Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigsCoronary Artery Disease, 18
H. Yip, Li-Teh Chang, Cheuk-Kwan Sun, A. Youssef, J. Sheu, Ching‐Jen Wang (2008)
Shock wave therapy applied to rat bone marrow-derived mononuclear cells enhances formation of cells stained positive for CD31 and vascular endothelial growth factor.Circulation journal : official journal of the Japanese Circulation Society, 72 1
Feng-Sheng Wang, Ching‐Jen Wang, Huei-Jen Huang, Hou Chung, Ron-Fu Chen, Kuender Yang, Kuender Yang (2001)
Physical shock wave mediates membrane hyperpolarization and Ras activation for osteogenesis in human bone marrow stromal cells.Biochemical and biophysical research communications, 287 3
M. Jessup, S. Brozena (2003)
Heart failureN Engl J Med, 348
Qian Hs, P. Liu, Huw Ly, A. Orme, M. Halks-Miller, Hill Sm, F. Jin, P. Kretschmer, E. Blasko, L. Cashion, P. Szymanski, R. Vergona, R. Harkins, Jun Yu, W. Sessa, Dole Wp, Gabor Rubanyi, K. Kauser (2006)
Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase geneGene Therapy, 13
K. Oi, Y. Fukumoto, K. Ito, T. Uwatoku, K. Abe, Takatoshi Hizume, H. Shimokawa (2008)
Extracorporeal shock wave therapy ameliorates hindlimb ischemia in rabbits.The Tohoku journal of experimental medicine, 214 2
A. Mathur, John Martin (2004)
Stem cells and repair of the heartThe Lancet, 364
E. Maisonhaute, A. White, R. Compton (2001)
Surface Acoustic Cavitation Understood via Nanosecond ElectrochemistryJournal of Physical Chemistry B, 105
J. Forrester, M. Price, R. Makkar (2003)
Stem cell repair of infarcted myocardium: an overview for clinicians.Circulation, 108 9
T. Nishida, H. Shimokawa, K. Oi, H. Tatewaki, T. Uwatoku, K. Abe, Y. Matsumoto, N. Kajihara, Masataka Eto, T. Matsuda, H. Yasui, A. Takeshita, K. Sunagawa (2004)
Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in VivoCirculation, 110
Tanveer Khan, Frank Sellke, R. Laham (2003)
Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemiaGene Therapy, 10
Y. Vasyuk, A. Hadzegova, E. Shkolnik, M. Kopeleva, O. Krikunova, E. Iouchtchouk, E. Aronova, S. Ivanova (2010)
Initial clinical experience with extracorporeal shock wave therapy in treatment of ischemic heart failure.Congestive heart failure, 16 5
V. Schächinger, B. Assmus, M. Britten, Jörg Honold, R. Lehmann, C. Teupe, N. Abolmaali, T. Vogl, W. Hofmann, H. Martin, S. Dimmeler, A. Zeiher (2004)
Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial.Journal of the American College of Cardiology, 44 8
A. Stojadinovic, E. Elster, K. Anam, D. Tadaki, M. Amare, Stephen Zins, T. Davis (2008)
Angiogenic response to extracorporeal shock wave treatment in murine skin isograftsAngiogenesis, 11
J. Regensteiner, K. Stewart (2006)
Established and evolving medical therapies for claudication in patients with peripheral arterial diseaseNature Clinical Practice Cardiovascular Medicine, 3
T. Asahara, T. Murohara, A. Sullivan, Marcy Silver, R. Zee, Tong Li, B. Witzenbichler, G. Schatteman, J. Isner (1997)
Isolation of Putative Progenitor Endothelial Cells for AngiogenesisScience, 275
K. Birnbaum, D. Wirtz, C. Siebert, K. Heller (2002)
Use of extracorporeal shock-wave therapy (ESWT) in the treatment of non-unionsArchives of Orthopaedic and Trauma Surgery, 122
K. Ito, Y. Fukumoto, H. Shimokawa (2009)
Extracorporeal shock wave therapy as a new and non-invasive angiogenic strategy.The Tohoku journal of experimental medicine, 219 1
A. Ciampa, A. Prati, E. Amelio, E. Cavalieri, T. Persichini, M. Colasanti, G. Musci, E. Marlinghaus, Hisanori Suzuki, S. Mariotto (2005)
Nitric oxide mediates anti‐inflammatory action of extracorporeal shock wavesFEBS Letters, 579
A. Volpi, Claudio Vita, M. Franzosi, E. Geraci, A. Maggioni, F. Mauri, E. Negri, E. Santoro, L. Tavazzi, G. Tognoni (1993)
Determinants of 6‐Month Mortality in Survivors of Myocardial Infarction After Thrombolysis Results of the GISSI‐2 Data BaseCirculation, 88
Masahiro Kajiguchi, T. Kondo, H. Izawa, Masayoshi Kobayashi, Koji Yamamoto, Satoshi Shintani, Y. Numaguchi, T. Naoe, J. Takamatsu, K. Komori, T. Murohara (2007)
Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia.Circulation journal : official journal of the Japanese Circulation Society, 71 2
M. Grunewald, I. Avraham, Y. Dor, E. Bachar-Lustig, A. Itin, S. Yung, S. Chimenti, Limor Landsman, R. Abramovitch, E. Keshet (2006)
VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory CellsCell, 124
B. Millauer, S. Wizigmann-Voos, H. Schnürch, R. Martinez, N. Møller, W. Risau, A. Ullrich (1993)
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesisCell, 72
S. Davani, F. Deschaseaux, D. Chalmers, P. Tiberghien, J. Kantelip (2005)
Can stem cells mend a broken heart?Cardiovascular research, 65 2
G. Gotte, E. Amelio, S. Russo, E. Marlinghaus, G. Musci, Hisanori Suzuki (2002)
Short‐time non‐enzymatic nitric oxide synthesis from L‐arginine and hydrogen peroxide induced by shock waves treatmentFEBS Letters, 520
R. Tamma, S. Dell'endice, A. Notarnicola, L. Moretti, Silvio Patella, V. Patella, A. Zallone, B. Moretti (2009)
Extracorporeal shock waves stimulate osteoblast activities.Ultrasound in medicine & biology, 35 12
T. Tatsumi, E. Ashihara, Toshihide Yasui, S. Matsunaga, A. Kido, Y. Sasada, Satoshi Nishikawa, M. Hadase, Masahiro Koide, Reo Nakamura, Hidekazu Irie, Kazuki Ito, Akihiro Matsui, Hiroyuki Matsui, M. Katamura, S. Kusuoka, S. Matoba, Satoshi Okayama, M. Horii, S. Uemura, C. Shimazaki, H. Tsuji, Yoshihiko Saito, H. Matsubara (2007)
Intracoronary Transplantation of Non-Expanded Peripheral Blood-Derived Mononuclear Cells Promotes Improvement of Cardiac Function in Patients With Acute Myocardial InfarctionCirculation, 71
K. Osterziel (2006)
Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1 year results of the REPAIR-AMI trial.European heart journal, 28 5
R. Apfel (1982)
Acoustic cavitation: a possible consequence of biomedical uses of ultrasound.The British journal of cancer. Supplement, 5
B. Sumpio (2000)
Primary care: Foot ulcersThe New England Journal of Medicine, 343
Stephen Epstein, S. Fuchs, Y. Zhou, R. Baffour, R. Kornowski (2001)
Therapeutic interventions for enhancing collateral development by administration of growth factors: basic principles, early results and potential hazards.Cardiovascular research, 49 3
Yu Wang, T. Guo, H. Cai, Tie-kun Ma, Si-ming Tao, Shu Sun, Ming-qing Chen, Y. Gu, Jia-Hua Pang, J. Xiao, Xiyun Yang, Chao Yang (2010)
Cardiac Shock Wave Therapy Reduces Angina and Improves Myocardial Function in Patients With Refractory Coronary Artery DiseaseClinical Cardiology, 33
B.E. Sumpio (2000)
Foot ulcersN Engl J Med, 343
J. Sheu, Cheuk-Kwan Sun, Li-Teh Chang, Hsiu‐Yu Fang, Sheng-ying Chung, Sarah Chua, M. Fu, F. Lee, Y. Kao, S. Ko, Ching‐Jen Wang, C. Yen, S. Leu, H. Yip (2010)
Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits.Annals of vascular surgery, 24 6
Aron Fisher, Shu Chien, A. Barakat, R. Nerem (2001)
Endothelial cellular response to altered shear stress.American journal of physiology. Lung cellular and molecular physiology, 281 3
Yoshihiro Fukumoto, A. Ito, T. Uwatoku, Tetsuya Matoba, T. Kishi, Haruki Tanaka, Akira Takeshita, Kenji Sunagawa, H. Shimokawa (2006)
Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery diseaseCoronary Artery Disease, 17
J. Kastrup, E. Jørgensen, A. Rück, K. Tägil, D. Glogar, W. Rużyłło, H. Bøtker, D. Dudek, V. Drvota, B. Hesse, L. Thuesen, P. Blomberg, M. Gyöngyösi, C. Sylvén (2005)
Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris A randomized double-blind placebo-controlled study: the Euroinject One trial.Journal of the American College of Cardiology, 45 7
Ching‐Jen Wang, Feng-Sheng Wang, Kuender Yang, L. Weng, Chia-Chen Hsu, Chun Huang, Lin-Cheng Yang (2003)
Shock wave therapy induces neovascularization at the tendon–bone junction. A study in rabbitsJournal of Orthopaedic Research, 21
G. Olivetti, R. Ricci, C. Beghi, G. Guideri, P. Anversa (1986)
Response of the border zone to myocardial infarction in rats.The American journal of pathology, 125 3
Xiaoyu Yan, B. Zeng, Y. Chai, C. Luo, Xiaolin Li (2008)
Improvement of Blood Flow, Expression of Nitric Oxide, and Vascular Endothelial Growth Factor by Low-Energy Shockwave Therapy in Random-Pattern Skin Flap ModelAnnals of Plastic Surgery, 61
Sheng Kang, Yuejin Yang, Chong-jian Li, R. Gao (2008)
Effects of intracoronary autologous bone marrow cells on left ventricular function in acute myocardial infarction: a systematic review and meta-analysis for randomized controlled trialsCoronary Artery Disease, 19
A. Kawamoto, T. Tkebuchava, J. Yamaguchi, Hiromi Nishimura, Y. Yoon, C. Milliken, S. Uchida, O. Masuo, H. Iwaguro, Hong Ma, A. Hanley, Marcy Silver, M. Kearney, Douglas Losordo, J. Isner, T. Asahara (2003)
Intramyocardial Transplantation of Autologous Endothelial Progenitor Cells for Therapeutic Neovascularization of Myocardial IschemiaCirculation: Journal of the American Heart Association, 107
S. Mariotto, E. Cavalieri, E. Amelio, A. Ciampa, A. Prati, E. Marlinghaus, S. Russo, Hisanori Suzuki (2005)
Extracorporeal shock waves: from lithotripsy to anti-inflammatory action by NO production.Nitric oxide : biology and chemistry, 12 2
S. Dimmeler, A. Zeiher, M. Schneider (2005)
Unchain my heart: the scientific foundations of cardiac repair.The Journal of clinical investigation, 115 3
J. Rutanen, T. Rissanen, J. Markkanen, M. Gruchała, Päivi Silvennoinen, A. Kivelä, A. Hedman, M. Hedman, T. Heikura, M. Ordén, S. Stacker, M. Achen, J. Hartikainen, S. Ylä-Herttuala (2004)
Adenoviral Catheter-Mediated Intramyocardial Gene Transfer Using the Mature Form of Vascular Endothelial Growth Factor-D Induces Transmural Angiogenesis in Porcine HeartCirculation: Journal of the American Heart Association, 109
Yoshitaka Ito, K. Ito, T. Shiroto, R. Tsuburaya, G. Yi, M. Takeda, Y. Fukumoto, S. Yasuda, H. Shimokawa (2010)
Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia–reperfusion injury in pigs in vivoCoronary Artery Disease, 21
I. Mheid, A.A. Quyyumi (2009)
Cell therapy in peripheral arterial diseaseAngiology, 59
S. Mariotto, A. Prati, E. Cavalieri, E. Amelio, E. Marlinghaus, Hisanori Suzuki (2009)
Extracorporeal shock wave therapy in inflammatory diseases: molecular mechanism that triggers anti-inflammatory action.Current medicinal chemistry, 16 19
Jin‐Ho Choi, Ji-Sun Choi, Wang-Soo Lee, I. Rhee, Sang-Chol Lee, H. Gwon, Sang Lee, Y. Choe, D. Kim, W. Suh, D. Kim, E. Jeon (2007)
Lack of additional benefit of intracoronary transplantation of autologous peripheral blood stem cell in patients with acute myocardial infarction.Circulation journal : official journal of the Japanese Circulation Society, 71 4
Jae-Sung Choi, Ki-Bong Kim, W. Han, Dong Kim, J. Park, Jong Lee, Dong Lee (2006)
Efficacy of therapeutic angiogenesis by intramyocardial injection of pCK-VEGF165 in pigs.The Annals of thoracic surgery, 82 2
S. Rafii, D. Lyden (2003)
Therapeutic stem and progenitor cell transplantation for organ vascularization and regenerationNature Medicine, 9
B. Moretti, A. Notarnicola, G. Maggio, L. Moretti, M. Pascone, S. Tafuri, V. Patella (2009)
The management of neuropathic ulcers of the foot in diabetes by shock wave therapyBMC Musculoskeletal Disorders, 10
Ischemic heart disease is the leading cause of death and a major cause of hospital admissions, with the number of affected patients increasing worldwide. The current management of ischemic heart disease has three major therapeutic options: medication, percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). However, the prognosis for patients with severe ischemic heart disease without indications for PCI or CABG still remains poor due to the lack of effective treatments. It is therefore crucial to develop alternative therapeutic strategies for severe ischemic heart disease. Extracorporeal shock wave (SW) therapy was introduced clinically more than 20 years ago to fragment kidney stones, which has markedly improved the treatment of urolithiasis. We found that a low-energy SW (about 10% of the energy density used for urolithiasis) effectively increases the expression of vascular endothelial growth factor (VEGF) in cultured endothelial cells. Based on this in vitro study, we initiated in vivo studies and have demonstrated that extracorporeal cardiac SW therapy with a low-energy SW up-regulates the expression of VEGF, induces neovascularization, and improves myocardial ischemia in a porcine model of chronic myocardial ischemia, without any adverse effects in vivo. On the basis of promising results in animal studies, we performed a series of clinical studies in patients with severe coronary artery disease without indication for PCI or CABG, including, firstly, an open trial followed by a placebo-controlled, double-blind study. In both studies, our extracorporeal cardiac SW therapy improved symptoms, exercise capacity, and myocardial perfusion in patients with severe coronary artery disease. Importantly, no procedural complications or adverse effects were noted. The SW therapy was also effective in ameliorating left ventricular remodeling after acute myocardial infarction (MI) in pigs and in enhancing angiogenesis in hind-limb ischemia in rabbits. Based on these animal studies, we are also conducting clinical studies in patients with acute MI and in those with peripheral artery disease. Thus, our extracorporeal cardiac SW therapy appears to be an effective, safe, and non-invasive angiogenic approach in cardiovascular medicine and its indication could be extended to a variety of ischemic diseases in the near future. In this article, we briefly summarize our work in animals and humans, and discuss the advantages and perspectives of our extracorporeal SW therapy.
American Journal of Cardiovascular Drugs – Springer Journals
Published: Aug 17, 2012
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