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Expression Patterns of Snail1, E-Cadherin and N-Cadherin Proteins in the Developing Kidney and in Wilms’ Tumor (Nephroblastoma)

Expression Patterns of Snail1, E-Cadherin and N-Cadherin Proteins in the Developing Kidney and in... Rare Cancers Ther (2014) 2:1–9 DOI 10.1007/s40487-014-0005-0 ORIGINAL RESEARCH Expression Patterns of Snail1, E-Cadherin and N-Cadherin Proteins in the Developing Kidney and in Wilms’ Tumor (Nephroblastoma) • • Sebastian Christoph Schmid Kareen Blechschmidt • • Stefan Schulz Karl Friedrich Becker Gregor Weirich To view enhanced content go to www.rarecancers-open.com Received: May 1, 2014 / Published online: July 16, 2014 The Author(s) 2014. This article is published with open access at Springerlink.com Results: Six of the childhood WT showed a ABSTRACT cytoplasmic Snail1 reaction. Adult WT were Introduction: Snail1 is a transcription factor that Snail1 negative. E-cadherin expression was suppresses E-cadherin. The roles of Snail1 and found in epithelial structures in eight of the E-cadherin in mesenchyme–epithelial transition nine WT. Tubular epithelial cells showed a Snail1 (MET) are not yet clear. We explored the role of positivity in the cytoplasm of seven kidneys. Snail1, E-cadherin and N-cadherin in fetal E-cadherin expression was found in epithelia of kidneys and compared it with Wilms’ tumor/ all ten fetal kidneys, but not in the mesenchyme. nephroblastoma (WT), a rare mesenchymal Four out of ten fetal kidneys and six out of nine kidney tumor, to better understand MET in WT were N-cadherin positive. One http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oncology and Therapy Springer Journals

Expression Patterns of Snail1, E-Cadherin and N-Cadherin Proteins in the Developing Kidney and in Wilms’ Tumor (Nephroblastoma)

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Publisher
Springer Journals
Copyright
Copyright © 2014 by The Author(s)
Subject
Medicine & Public Health; Internal Medicine
ISSN
2366-1070
eISSN
2195-6022
DOI
10.1007/s40487-014-0005-0
Publisher site
See Article on Publisher Site

Abstract

Rare Cancers Ther (2014) 2:1–9 DOI 10.1007/s40487-014-0005-0 ORIGINAL RESEARCH Expression Patterns of Snail1, E-Cadherin and N-Cadherin Proteins in the Developing Kidney and in Wilms’ Tumor (Nephroblastoma) • • Sebastian Christoph Schmid Kareen Blechschmidt • • Stefan Schulz Karl Friedrich Becker Gregor Weirich To view enhanced content go to www.rarecancers-open.com Received: May 1, 2014 / Published online: July 16, 2014 The Author(s) 2014. This article is published with open access at Springerlink.com Results: Six of the childhood WT showed a ABSTRACT cytoplasmic Snail1 reaction. Adult WT were Introduction: Snail1 is a transcription factor that Snail1 negative. E-cadherin expression was suppresses E-cadherin. The roles of Snail1 and found in epithelial structures in eight of the E-cadherin in mesenchyme–epithelial transition nine WT. Tubular epithelial cells showed a Snail1 (MET) are not yet clear. We explored the role of positivity in the cytoplasm of seven kidneys. Snail1, E-cadherin and N-cadherin in fetal E-cadherin expression was found in epithelia of kidneys and compared it with Wilms’ tumor/ all ten fetal kidneys, but not in the mesenchyme. nephroblastoma (WT), a rare mesenchymal Four out of ten fetal kidneys and six out of nine kidney tumor, to better understand MET in WT were N-cadherin positive. One

Journal

Oncology and TherapySpringer Journals

Published: Jul 16, 2014

References