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Expression of the epithelial polymeric immunoglobulin receptor is decreased in allergic rhinitis and eosinophilic rhinosinusitis

Expression of the epithelial polymeric immunoglobulin receptor is decreased in allergic rhinitis... Hupin et al. Clinical and Translational Allergy 2013, 3(Suppl 2):O8 http://www.ctajournal.com/content/3/S2/O8 ORAL PRESENTATION Open Access Expression of the epithelial polymeric immunoglobulin receptor is decreased in allergic rhinitis and eosinophilic rhinosinusitis 1* 1 2 2 Cloé Hupin , Philippe Rombaux , Marylène Lecocq , Charles Pilette From 9th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2013) Leuven, Belgium. 21-23 March 2013 Background was mainly observed in patients with increased mucosal Transcytosis of immunoglobulin A (IgA) through polarized eosinophils. bronchial and sinonasal epithelial cells is mediated by the polymeric immunoglobulin receptor (pIgR), which repre- Conclusion sents the rate-limiting factor for this frontline protective Epithelial pIgR expression is decreased in patients with mechanism in the airways. pIgR expression is decreased in CRSwNP and AR, results in decreased SC (and IgA) in COPD, lung cancer and nasopharyngeal carcinoma, while nasal secretions, and closely relates to Th2-type eosinophi- its role in sinonasal chronic inflammatory diseases has not lic inflammation. Whether this defect leads to impaired been explored. The aim of this study was thus to assess defense of the upper airways against pathogens remains to pIgR expression in sinonasal mucosa of patient with explore. chronic rhinosinusitis with (CRSwNP) or without polyps (CRSsNP) and in allergic rhinitis (AR), as well as IgA Author details and SC (the released soluble part of the pIgR) in nasal Cliniques Universitaires Saint-Luc, Service d’Oto-Rhino-Laryngologie, Brussels, Belgium. Université Catholique de Louvain, IREC, Pole de Pneumologie, ORL secretions. & Dermatologie, Brussels, Belgium. Methods Published: 16 July 2013 Nasal and ethmoidal biopsies, as well as nasal fluid, were collected from patients with CRSwNP, CRSsNP and AR, doi:10.1186/2045-7022-3-S2-O8 as compared to control subjects. pIgR expression was ana- Cite this article as: Hupin et al.: Expression of the epithelial polymeric lyzed by RT-qPCR and immunohistochemistry. IgA and immunoglobulin receptor is decreased in allergic rhinitis and SC were measured in nasal secretions by ELISA. Quantifi- eosinophilic rhinosinusitis. Clinical and Translational Allergy 2013 3(Suppl 2):O8. cation of mucosal eosinophils was performed following hematoxylin-eosin staining. Submit your next manuscript to BioMed Central Results and take full advantage of: RT-qPCR showed a significant reduction of pIgR expres- sion in ethmoidal biopsies from CRSwNP (p = 0,01) and • Convenient online submission AR (p = 0,04). This reduction was confirmed at the pro- • Thorough peer review tein level by immunohistochemistry, and resulted into • No space constraints or color figure charges reduced levels of SC and trends for reduced IgA in nasal • Immediate publication on acceptance secretions from these patients. Decreased pIgR expression • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Cliniques Universitaires Saint-Luc, Service d’Oto-Rhino-Laryngologie, Brussels, Submit your manuscript at Belgium www.biomedcentral.com/submit Full list of author information is available at the end of the article © 2013 Hupin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Translational Allergy Springer Journals

Expression of the epithelial polymeric immunoglobulin receptor is decreased in allergic rhinitis and eosinophilic rhinosinusitis

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Hupin et al; licensee BioMed Central Ltd.
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
2045-7022
DOI
10.1186/2045-7022-3-S2-O8
Publisher site
See Article on Publisher Site

Abstract

Hupin et al. Clinical and Translational Allergy 2013, 3(Suppl 2):O8 http://www.ctajournal.com/content/3/S2/O8 ORAL PRESENTATION Open Access Expression of the epithelial polymeric immunoglobulin receptor is decreased in allergic rhinitis and eosinophilic rhinosinusitis 1* 1 2 2 Cloé Hupin , Philippe Rombaux , Marylène Lecocq , Charles Pilette From 9th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2013) Leuven, Belgium. 21-23 March 2013 Background was mainly observed in patients with increased mucosal Transcytosis of immunoglobulin A (IgA) through polarized eosinophils. bronchial and sinonasal epithelial cells is mediated by the polymeric immunoglobulin receptor (pIgR), which repre- Conclusion sents the rate-limiting factor for this frontline protective Epithelial pIgR expression is decreased in patients with mechanism in the airways. pIgR expression is decreased in CRSwNP and AR, results in decreased SC (and IgA) in COPD, lung cancer and nasopharyngeal carcinoma, while nasal secretions, and closely relates to Th2-type eosinophi- its role in sinonasal chronic inflammatory diseases has not lic inflammation. Whether this defect leads to impaired been explored. The aim of this study was thus to assess defense of the upper airways against pathogens remains to pIgR expression in sinonasal mucosa of patient with explore. chronic rhinosinusitis with (CRSwNP) or without polyps (CRSsNP) and in allergic rhinitis (AR), as well as IgA Author details and SC (the released soluble part of the pIgR) in nasal Cliniques Universitaires Saint-Luc, Service d’Oto-Rhino-Laryngologie, Brussels, Belgium. Université Catholique de Louvain, IREC, Pole de Pneumologie, ORL secretions. & Dermatologie, Brussels, Belgium. Methods Published: 16 July 2013 Nasal and ethmoidal biopsies, as well as nasal fluid, were collected from patients with CRSwNP, CRSsNP and AR, doi:10.1186/2045-7022-3-S2-O8 as compared to control subjects. pIgR expression was ana- Cite this article as: Hupin et al.: Expression of the epithelial polymeric lyzed by RT-qPCR and immunohistochemistry. IgA and immunoglobulin receptor is decreased in allergic rhinitis and SC were measured in nasal secretions by ELISA. Quantifi- eosinophilic rhinosinusitis. Clinical and Translational Allergy 2013 3(Suppl 2):O8. cation of mucosal eosinophils was performed following hematoxylin-eosin staining. Submit your next manuscript to BioMed Central Results and take full advantage of: RT-qPCR showed a significant reduction of pIgR expres- sion in ethmoidal biopsies from CRSwNP (p = 0,01) and • Convenient online submission AR (p = 0,04). This reduction was confirmed at the pro- • Thorough peer review tein level by immunohistochemistry, and resulted into • No space constraints or color figure charges reduced levels of SC and trends for reduced IgA in nasal • Immediate publication on acceptance secretions from these patients. Decreased pIgR expression • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Cliniques Universitaires Saint-Luc, Service d’Oto-Rhino-Laryngologie, Brussels, Submit your manuscript at Belgium www.biomedcentral.com/submit Full list of author information is available at the end of the article © 2013 Hupin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Journal

Clinical and Translational AllergySpringer Journals

Published: Jul 16, 2013

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