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Expression of Platelet Surface Receptors and Early Changes in Platelet Function in Patients with STEMI Treated with Abciximab and Clopidogrel versus Clopidogrel Alone

Expression of Platelet Surface Receptors and Early Changes in Platelet Function in Patients with... Am J Cardiovasc Drugs 2007; 7 (6): 433-439 ORIGINAL RESEARCH ARTICLE 1175-3277/07/0006-0433/$44.95/0 © 2007 Adis Data Information BV. All rights reserved. Expression of Platelet Surface Receptors and Early Changes in Platelet Function in Patients with STEMI Treated with Abciximab and Clopidogrel versus Clopidogrel Alone Anna Konopka, Justyna Spychalska, Dariusz Sitkiewicz, Ewa Zdebska , Iwona Pilichowska, Walerian Piotrowski and Janina Stepinska Institute of Cardiology and Institute of Haematology and Blood Transfusion in Warsaw, Warsaw, Poland Abstract Background: Platelets play a crucial role in the pathogenesis of acute coronary syndromes (ACS). The efficacy of antiplatelet treatment is pivotal in the success of percutaneous coronary intervention (PCI) performed in patients with ACS. Objective: The aim of the study was to investigate the effects of clopidogrel with or without abciximab on the expression of platelet surface receptors and platelet function in patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI. Materials and methods: Thirty patients with STEMI were included in the study. During acute primary coronary intervention, patients received aspirin (acetylsalicylic acid) and clopidogrel in a loading dose of 300mg. Clopidogrel was the only antiplatelet therapy used by nine patients (group B). Twenty-one patients (group A) received additional abciximab. Blood samples were collected http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cardiovascular Drugs Springer Journals

Expression of Platelet Surface Receptors and Early Changes in Platelet Function in Patients with STEMI Treated with Abciximab and Clopidogrel versus Clopidogrel Alone

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References (18)

Publisher
Springer Journals
Copyright
Copyright © 2007 by Adis Data Information BV
Subject
Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
ISSN
1175-3277
eISSN
1179-187X
DOI
10.2165/00129784-200707060-00006
pmid
18076210
Publisher site
See Article on Publisher Site

Abstract

Am J Cardiovasc Drugs 2007; 7 (6): 433-439 ORIGINAL RESEARCH ARTICLE 1175-3277/07/0006-0433/$44.95/0 © 2007 Adis Data Information BV. All rights reserved. Expression of Platelet Surface Receptors and Early Changes in Platelet Function in Patients with STEMI Treated with Abciximab and Clopidogrel versus Clopidogrel Alone Anna Konopka, Justyna Spychalska, Dariusz Sitkiewicz, Ewa Zdebska , Iwona Pilichowska, Walerian Piotrowski and Janina Stepinska Institute of Cardiology and Institute of Haematology and Blood Transfusion in Warsaw, Warsaw, Poland Abstract Background: Platelets play a crucial role in the pathogenesis of acute coronary syndromes (ACS). The efficacy of antiplatelet treatment is pivotal in the success of percutaneous coronary intervention (PCI) performed in patients with ACS. Objective: The aim of the study was to investigate the effects of clopidogrel with or without abciximab on the expression of platelet surface receptors and platelet function in patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI. Materials and methods: Thirty patients with STEMI were included in the study. During acute primary coronary intervention, patients received aspirin (acetylsalicylic acid) and clopidogrel in a loading dose of 300mg. Clopidogrel was the only antiplatelet therapy used by nine patients (group B). Twenty-one patients (group A) received additional abciximab. Blood samples were collected

Journal

American Journal of Cardiovascular Drugs – Springer Journals

Published: Aug 17, 2012

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