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Experimental diabetes: No effects on prostacyclin release from the vessel wall and renal cortex

Experimental diabetes: No effects on prostacyclin release from the vessel wall and renal cortex Diabetes is commonly complicated by thrombosis and atherosclerosis. In humans, diabetes mellitus has been associated with a decreased synthesis of prostacyclin, which could partly explain the prothrombotic state. Experimental diabetes has been diverging in this aspect, and endothelial damage has been proposed to be an early event. To analyse whether the effect of inducing diabetes had any influence on prostacyclin release from diabetic tissue, streptozotocin-induced diabetic rat aortas and renal tissue were incubated in Hank's balanced salt solution. The stable degradation product for prostacyclin 6-keto-PGF1α was determined by radioimmunoassay. There was no difference in the release of 6-keto-PGF1α from aorta and renal tissue in diabetic animals compared to controls, and insulin given to diabetic animals also had no effect. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Experimental diabetes: No effects on prostacyclin release from the vessel wall and renal cortex

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References (69)

Publisher
Springer Journals
Copyright
Copyright © 1993 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF00368111
Publisher site
See Article on Publisher Site

Abstract

Diabetes is commonly complicated by thrombosis and atherosclerosis. In humans, diabetes mellitus has been associated with a decreased synthesis of prostacyclin, which could partly explain the prothrombotic state. Experimental diabetes has been diverging in this aspect, and endothelial damage has been proposed to be an early event. To analyse whether the effect of inducing diabetes had any influence on prostacyclin release from diabetic tissue, streptozotocin-induced diabetic rat aortas and renal tissue were incubated in Hank's balanced salt solution. The stable degradation product for prostacyclin 6-keto-PGF1α was determined by radioimmunoassay. There was no difference in the release of 6-keto-PGF1α from aorta and renal tissue in diabetic animals compared to controls, and insulin given to diabetic animals also had no effect.

Journal

Comparative Clinical PathologySpringer Journals

Published: Jul 9, 2004

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