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Diabetes is commonly complicated by thrombosis and atherosclerosis. In humans, diabetes mellitus has been associated with a decreased synthesis of prostacyclin, which could partly explain the prothrombotic state. Experimental diabetes has been diverging in this aspect, and endothelial damage has been proposed to be an early event. To analyse whether the effect of inducing diabetes had any influence on prostacyclin release from diabetic tissue, streptozotocin-induced diabetic rat aortas and renal tissue were incubated in Hank's balanced salt solution. The stable degradation product for prostacyclin 6-keto-PGF1α was determined by radioimmunoassay. There was no difference in the release of 6-keto-PGF1α from aorta and renal tissue in diabetic animals compared to controls, and insulin given to diabetic animals also had no effect.
Comparative Clinical Pathology – Springer Journals
Published: Jul 9, 2004
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