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Exogenous and Endogenous Neuroactive Biogenic Amines: Studies with Lactococcus lactis subsp. lactis

Exogenous and Endogenous Neuroactive Biogenic Amines: Studies with Lactococcus lactis subsp. lactis ISSN 0003-6838, Applied Biochemistry and Microbiology, 2018, Vol. 54, No. 6, pp. 603–610. © Pleiades Publishing, Inc., 2018. Exogenous and Endogenous Neuroactive Biogenic Amines: Studies with Lactococcus lactis subsp. lactis a, a a a I. R. Vodolazov *, S. D. Dbar , A. V. Oleskin , and L. G. Stoyanova Lomonosov Moscow State University, Biological Faculty, Moscow, 119234 Russia *e-mail: voidset@ya.ru Received May 15, 2018 Abstract—This work demonstrates that Lactococcus lactis subsp. lactis strains that display antimicrobial activity with respect to test cultures (potential pathogens) synthesize biogenic amines. Strains K-205 and F-116 produce submicromolar amounts of dopamine and its 2,3-dihydroxyphenylalanine precursor (DOPA) in a medium that is devoid of dopamine and DOPA. It was also revealed that exogenous neuromediators such as adrenaline (epi- nephrine), dopamine, and serotonin stimulated the growth and antimicrobial activity of some strains at micro- molar concentrations. The growth of L. lactis subsp. lactis strain 194 was threefold accelerated by all the neu- rotransmitters. The stimulatory effect was observed after 6 and 12 h of cultivation. Epinephrine and serotonin failed to produce a statistically signif icant effect on the growth of the other tested strains (K-205, 729, and F-116). Among the neurochemicals under study, dopamine exerted http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Biochemistry and Microbiology Springer Journals

Exogenous and Endogenous Neuroactive Biogenic Amines: Studies with Lactococcus lactis subsp. lactis

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References (3)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Pleiades Publishing, Inc.
Subject
Life Sciences; Biochemistry, general; Microbiology; Medical Microbiology
ISSN
0003-6838
eISSN
1608-3024
DOI
10.1134/S0003683818060157
Publisher site
See Article on Publisher Site

Abstract

ISSN 0003-6838, Applied Biochemistry and Microbiology, 2018, Vol. 54, No. 6, pp. 603–610. © Pleiades Publishing, Inc., 2018. Exogenous and Endogenous Neuroactive Biogenic Amines: Studies with Lactococcus lactis subsp. lactis a, a a a I. R. Vodolazov *, S. D. Dbar , A. V. Oleskin , and L. G. Stoyanova Lomonosov Moscow State University, Biological Faculty, Moscow, 119234 Russia *e-mail: voidset@ya.ru Received May 15, 2018 Abstract—This work demonstrates that Lactococcus lactis subsp. lactis strains that display antimicrobial activity with respect to test cultures (potential pathogens) synthesize biogenic amines. Strains K-205 and F-116 produce submicromolar amounts of dopamine and its 2,3-dihydroxyphenylalanine precursor (DOPA) in a medium that is devoid of dopamine and DOPA. It was also revealed that exogenous neuromediators such as adrenaline (epi- nephrine), dopamine, and serotonin stimulated the growth and antimicrobial activity of some strains at micro- molar concentrations. The growth of L. lactis subsp. lactis strain 194 was threefold accelerated by all the neu- rotransmitters. The stimulatory effect was observed after 6 and 12 h of cultivation. Epinephrine and serotonin failed to produce a statistically signif icant effect on the growth of the other tested strains (K-205, 729, and F-116). Among the neurochemicals under study, dopamine exerted

Journal

Applied Biochemistry and MicrobiologySpringer Journals

Published: Dec 19, 2018

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