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Evolving strategies to overcome endocrine resistance in breast cancer

Evolving strategies to overcome endocrine resistance in breast cancer Endocrine therapies targeting estrogen action decrease mortality from breast cancer, but their efficacy is limited by intrinsic and acquired therapeutic resistance. Various mechanisms can contribute to insensitivity toward endocrine treatment in hormone receptor-positive breast cancer patients. Definition of the specific genetic lesions and molecular processes that determine clinical endocrine resistance is still incomplete but recently tremendous advances have been made. In this short review the latest strategies to overcome endocrine resistance will be discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png memo - Magazine of European Medical Oncology Springer Journals

Evolving strategies to overcome endocrine resistance in breast cancer

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Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer-Verlag Wien
Subject
Medicine & Public Health; Medicine/Public Health, general; Oncology
ISSN
1865-5041
eISSN
1865-5076
DOI
10.1007/s12254-012-0003-6
Publisher site
See Article on Publisher Site

Abstract

Endocrine therapies targeting estrogen action decrease mortality from breast cancer, but their efficacy is limited by intrinsic and acquired therapeutic resistance. Various mechanisms can contribute to insensitivity toward endocrine treatment in hormone receptor-positive breast cancer patients. Definition of the specific genetic lesions and molecular processes that determine clinical endocrine resistance is still incomplete but recently tremendous advances have been made. In this short review the latest strategies to overcome endocrine resistance will be discussed.

Journal

memo - Magazine of European Medical OncologySpringer Journals

Published: May 30, 2012

References