Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Etiology of exercise-induced asthma: Physical stress-induced transcription

Etiology of exercise-induced asthma: Physical stress-induced transcription Exercise-induced asthma (EIA) occurs with a high prevalence in both asthmatic and nonasthmatic individuals. Although understanding of the functional genomics (proteomics) in sports medicine remains limited, this review focuses on immunologic changes as reflected in transcriptional regulation in respect to EIA. Studies demonstrated that leukotrienes play a significant role in EIA. Exercise increases the distribution of leukotrienes and influences the leukotriene transcription pathway; it could be shown that the genes ALOX5 and ALOX5AP encoding for 5-lipooxygenase (5-LO) and 5-lipoxygenase—activating protein (FLAP) as well as activators for 5-LO, p38 mitogen-activated protein kinase (MAPK), and others, are enhanced after exercise in healthy subjects. Possibly EIA is triggered via leukotriene release if a predisposition or other conditions (eg, epithelial injury and repair) are present. Furthermore, exercise influences transcription factors such as nuclear factor-kappa B (NF-κB), activator protein-1 (AP1), cytokines, and chemokines and promotes cellular responses linked to EIA, which are possibly able to modify further the incidence or the severity of EIA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Etiology of exercise-induced asthma: Physical stress-induced transcription

Hilberg, Thomas
Current Allergy and Asthma Reports , Volume 7 (1) – May 30, 2007
Download PDF
6 pages

Loading next page...
 
/lp/springer-journals/etiology-of-exercise-induced-asthma-physical-stress-induced-Gwep6r4BIi

References (51)

Publisher
Springer Journals
Copyright
Copyright © 2007 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Infectious Diseases; Otorhinolaryngology; Pneumology/Respiratory System; Allergology
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-007-0027-x
Publisher site
See Article on Publisher Site

Abstract

Exercise-induced asthma (EIA) occurs with a high prevalence in both asthmatic and nonasthmatic individuals. Although understanding of the functional genomics (proteomics) in sports medicine remains limited, this review focuses on immunologic changes as reflected in transcriptional regulation in respect to EIA. Studies demonstrated that leukotrienes play a significant role in EIA. Exercise increases the distribution of leukotrienes and influences the leukotriene transcription pathway; it could be shown that the genes ALOX5 and ALOX5AP encoding for 5-lipooxygenase (5-LO) and 5-lipoxygenase—activating protein (FLAP) as well as activators for 5-LO, p38 mitogen-activated protein kinase (MAPK), and others, are enhanced after exercise in healthy subjects. Possibly EIA is triggered via leukotriene release if a predisposition or other conditions (eg, epithelial injury and repair) are present. Furthermore, exercise influences transcription factors such as nuclear factor-kappa B (NF-κB), activator protein-1 (AP1), cytokines, and chemokines and promotes cellular responses linked to EIA, which are possibly able to modify further the incidence or the severity of EIA.

Journal

Current Allergy and Asthma Reports – Springer Journals

Published: May 30, 2007

There are no references for this article.