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Ethoxylation of p -Fluoronitrobenzene using phase-transfer catalysts under microflow conditions

Ethoxylation of p -Fluoronitrobenzene using phase-transfer catalysts under microflow conditions Abstract Nucleophilic aromatic substitution, one of the most common transformation methods for aromatic organic compounds, is often performed under biphasic conditions using a phase-transfer catalyst. Herein, we investigated the synthesis of 4-nitrophenetole from 4-fluoronitrobenzene in a continuous-flow microreactor, which accelerates mass transfer between the two phases. The reaction proceeded smoothly under slug flow conditions and a slight acceleration effect was observed under ambient pressure. By contrast, high temperature and pressure conditions gave the target compound in good yield within a shorter residence time. Graphical Abstract Please provide caption for graphical abstract.Nucleophilic aromatic Substitution under microflow conditions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Ethoxylation of p -Fluoronitrobenzene using phase-transfer catalysts under microflow conditions

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Publisher
Springer Journals
Copyright
2019 Akadémiai Kiadó
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-019-00032-1
Publisher site
See Article on Publisher Site

Abstract

Abstract Nucleophilic aromatic substitution, one of the most common transformation methods for aromatic organic compounds, is often performed under biphasic conditions using a phase-transfer catalyst. Herein, we investigated the synthesis of 4-nitrophenetole from 4-fluoronitrobenzene in a continuous-flow microreactor, which accelerates mass transfer between the two phases. The reaction proceeded smoothly under slug flow conditions and a slight acceleration effect was observed under ambient pressure. By contrast, high temperature and pressure conditions gave the target compound in good yield within a shorter residence time. Graphical Abstract Please provide caption for graphical abstract.Nucleophilic aromatic Substitution under microflow conditions

Journal

Journal of Flow ChemistrySpringer Journals

Published: Jun 1, 2019

References