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Erythrocyte metabolism in the gibbon, the elephant and the lion

Erythrocyte metabolism in the gibbon, the elephant and the lion Erythrocyte metabolism was studied in the white-handed gibbon (Hylobatus leucogenys), the Asian elephant (Elephas maximus) and the lion (Panthera leo). Aspects of metabolism studied were activities of the enzymes associated with glycolysis and the antioxidant defence systems, glycolytic rates using four different substrates and the susceptibility of haemoglobin to three different oxidising agents, acetylphenylhydrazine (APH), hydrogen peroxide (H202) and sodium nitrite (NaNO2). The main findings were as follows. First, compared with humans, the erythrocytes from the gibbon were more resistant to H202-induced haemolysis and had very high activity of NADH-methaemoglobin reductase. Oxidation of haemoglobin by NaNO2 was largely blocked by 0.1 mM GSH. Second, the erythrocytes from the lion had a very high activity of pyruvate kinase (PK). The rate of methaemoglobin formation by APH was also very high in these erythrocytes. Third, the erythrocytes of the elephant had very low levels of hexokinase and PK and were more resistant to oxidant stress than those of the lion and humans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Erythrocyte metabolism in the gibbon, the elephant and the lion

Agar, N.; Gay, C.
Comparative Clinical Pathology , Volume 5 (3) – Sep 8, 2004
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References (29)

Publisher
Springer Journals
Copyright
Copyright © 1995 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF00368038
Publisher site
See Article on Publisher Site

Abstract

Erythrocyte metabolism was studied in the white-handed gibbon (Hylobatus leucogenys), the Asian elephant (Elephas maximus) and the lion (Panthera leo). Aspects of metabolism studied were activities of the enzymes associated with glycolysis and the antioxidant defence systems, glycolytic rates using four different substrates and the susceptibility of haemoglobin to three different oxidising agents, acetylphenylhydrazine (APH), hydrogen peroxide (H202) and sodium nitrite (NaNO2). The main findings were as follows. First, compared with humans, the erythrocytes from the gibbon were more resistant to H202-induced haemolysis and had very high activity of NADH-methaemoglobin reductase. Oxidation of haemoglobin by NaNO2 was largely blocked by 0.1 mM GSH. Second, the erythrocytes from the lion had a very high activity of pyruvate kinase (PK). The rate of methaemoglobin formation by APH was also very high in these erythrocytes. Third, the erythrocytes of the elephant had very low levels of hexokinase and PK and were more resistant to oxidant stress than those of the lion and humans.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Sep 8, 2004

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