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P. Hopkins, Lily Wu, S. Hunt, B. James, G. Vincent, Roger Williams (1996)
Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease.Arteriosclerosis, thrombosis, and vascular biology, 16 2
T. Gori, A. Daiber (2009)
Non-Hemodynamic Effects of Organic Nitrates and the Distinctive Characteristics of Pentaerithrityl TetranitrateAmerican Journal of Cardiovascular Drugs, 9
B. Schnorbus, R. Schiewe, M. Ostad, Christoph Medler, D. Wachtlin, P. Wenzel, A. Daiber, T. Münzel, A. Warnholtz (2010)
Effects of pentaerythritol tetranitrate on endothelial function in coronary artery disease: results of the PENTA studyClinical Research in Cardiology, 99
Georg Kojda, A. Hacker, Eike Noack (1998)
Effects of nonintermittent treatment of rabbits with pentaerythritol tetranitrate on vascular reactivity and superoxide production.European journal of pharmacology, 355 1
G. Thomas, Jonathan DiFabio, T. Gori, J. Parker (2007)
Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism.Journal of the American College of Cardiology, 49 12
G. Pieper, G. Gross (1988)
Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta.The American journal of physiology, 255 4 Pt 2
S. Oberle, Petra Schwartz, A. Abate, H. Schröder (1999)
The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells.Biochemical and biophysical research communications, 261 1
J. Knight (1998)
Free radicals: their history and current status in aging and disease.Annals of clinical and laboratory science, 28 6
M. Kichuk, N. Seyedi, X. Zhang, C. Marboe, R. Michler, L. Addonizio, G. Kaley, A. Nasjletti, T. Hintze (1996)
Regulation of nitric oxide production in human coronary microvessels and the contribution of local kinin formation.Circulation, 94 1
B. Williams, B. Gallacher, Hash Patel, Carole Orme (1997)
Glucose-Induced Protein Kinase C Activation Regulates Vascular Permeability Factor mRNA Expression and Peptide Production by Human Vascular Smooth Muscle Cells In VitroDiabetes, 46
M Brownlee (2001)
Biochemistry and molecular cell biology of diabetic complicationsNature, 414
Insight Review Articles
P. Wenzel, M. Oelze, M. Coldewey, M. Hortmann, A. Seeling, U. Hink, H. Mollnau, D. Stalleicken, H. Weiner, J. Lehmann, Huige Li, U. Förstermann, T. Münzel, A. Daiber (2007)
Heme Oxygenase-1: A Novel Key Player in the Development of Tolerance in Response to Organic NitratesArteriosclerosis, Thrombosis, and Vascular Biology, 27
M. Carli, M. Tobes, T. Mangner, A. Levine, O. Muzik, Pulak Chakroborty, T. Levine (1997)
Effects of cardiac sympathetic innervation on coronary blood flow.The New England journal of medicine, 336 17
T. Gori, A. Al-hesayen, C. Jolliffe, J. Parker (2003)
Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers.The American journal of cardiology, 91 11
E. Standl, O. Schnell (2000)
A new look at the heart in diabetes mellitus: from ailing to failingDiabetologia, 43
U. Jurt, T. Gori, A. Ravandi, Saeid Babaei, P. Zeman, J. Parker (2001)
Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study.Journal of the American College of Cardiology, 38 3
S. Wilson, D. Celermajer, A. Nakagomi, R. Wyndham, M. Janu, S. Freedman (1999)
Vascular risk factors correlate to the extent as well as the severity of coronary atherosclerosis.Coronary artery disease, 10 7
A. Daiber, P. Wenzel, M. Oelze, T. Münzel (2007)
New insights into bioactivation of organic nitrates, nitrate tolerance and cross-toleranceClinical Research in Cardiology, 97
M. Sekiya, Makoto Sato, J. Funada, T. Ohtani, H. Akutsu, Kouki Watanabe (2005)
Effects of the Long-Term Administration of Nicorandil on Vascular Endothelial Function and the Progression of ArteriosclerosisJournal of Cardiovascular Pharmacology, 46
A. Daiber, P. Wenzel, M. Oelze, Swenja Schuhmacher, T. Jansen, T. Münzel (2009)
Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment.Chemico-biological interactions, 178 1-3
L. Otterbein, A. Choi (2000)
Heme oxygenase: colors of defense against cellular stress.American journal of physiology. Lung cellular and molecular physiology, 279 6
Eberhard Schulz, N. Tsilimingas, R. Rinze, B. Reiter, M. Wendt, M. Oelze, Silke Woelken-Weckmüller, U. Walter, H. Reichenspurner, T. Meinertz, T. Münzel (2002)
Functional and Biochemical Analysis of Endothelial (Dys)function and NO/cGMP Signaling in Human Blood Vessels With and Without Nitroglycerin PretreatmentCirculation: Journal of the American Heart Association, 105
N. Abraham, A. Asija, G. Drummond, S. Peterson (2007)
Heme oxygenase -1 gene therapy: recent advances and therapeutic applications.Current gene therapy, 7 2
M. Lorenzi, E. Cagliero (1991)
Pathobiology of Endothelial and Other Vascular Cells in Diabetes Mellitus: Call for DataDiabetes, 40
R. Palmer, A. Ferrige, S. Moncada (1987)
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorNature, 327
(2005)
Explaining the phenomenon of nitrate tolerance.Circulation research, 97 7
S. Baumgartner‐Parzer, L. Wagner, M. Pettermann, A. Gessl, W. Waldhäusl (1995)
Modulation by high glucose of adhesion molecule expression in cultured endothelial cellsDiabetologia, 38
C. Granger, R. Califf, S. Young, R. Candela, Joseph Samara, S. Worley, D. Kereiakes, E. Topol (1993)
Outcome of patients with diabetes mellitus and acute myocardial infarction treated with thrombolytic agents. The Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group.Journal of the American College of Cardiology, 21 4
Wolfgang Otter, S. Kleybrink, Wittich Doering, Eberhard Standl, O. Schnell (2004)
Hospital outcome of acute myocardial infarction in patients with and without diabetes mellitusDiabetic Medicine, 21
Yen-Hsu Chen, S. yet, M. Perrella (2003)
Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac FunctionExperimental Biology and Medicine, 228
S. Oberle, A. Abate, N. Grosser, Anke Hemmerle, H. Vreman, P. Dennery, H. Schneider, D. Stalleicken, H. Schröder (2003)
Endothelial Protection by Pentaerithrityl Trinitrate: Bilirubin and Carbon Monoxide as Possible MediatorsExperimental Biology and Medicine, 228
Sergey Dikalov, B. Fink, M. Skatchkov, Eberhard Bassenge (1999)
Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C.Free radical biology & medicine, 27 1-2
T. Thum, D. Fraccarollo, Sabrina Thum, M. Schultheiss, A. Daiber, P. Wenzel, T. Munzel, G. Ertl, J. Bauersachs (2007)
Differential Effects of Organic Nitrates on Endothelial Progenitor Cells Are Determined by Oxidative StressArteriosclerosis, Thrombosis, and Vascular Biology, 27
Zhiqiang Chen, Jian Zhang, J. Stamler (2002)
Identification of the enzymatic mechanism of nitroglycerin bioactivationProceedings of the National Academy of Sciences of the United States of America, 99
A. Pautz, P. Rauschkolb, Nadine Schmidt, J. Art, M. Oelze, P. Wenzel, U. Förstermann, A. Daiber, H. Kleinert (2009)
Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects.Physiological genomics, 38 2
I. Yokoyama, S. Momomura, T. Ohtake, K. Yonekura, J. Nishikawa, Y. Sasaki, M. Omata (1997)
Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus.Journal of the American College of Cardiology, 30 6
O Schnell, D Stalleicken, N Marx (2009)
Endothelfunktion und oxidativer Stress bei Diabetes – Nutzen eines LangzeitnitratsDiabetes, Stoffwechsel und Herz, 18
L. Vítek, H. Schwertner (2007)
The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases.Advances in clinical chemistry, 43
N. Hattori, O. Schnell, F. Bengel, J. Rihl, S. Nekolla, A. Drzezga, E. Standl, M. Schwaiger (2002)
Deferoxamine improves coronary vascular responses to sympathetic stimulation in patients with type 1 diabetes mellitusEuropean Journal of Nuclear Medicine and Molecular Imaging, 29
Adam Kruger, S. Peterson, M. Schwartzman, H. Fusco, J. McClung, M. Weiss, S. Shenouda, A. Goodman, M. Goligorsky, A. Kappas, N. Abraham (2006)
Up-Regulation of Heme Oxygenase Provides Vascular Protection in an Animal Model of Diabetes through Its Antioxidant and Antiapoptotic EffectsJournal of Pharmacology and Experimental Therapeutics, 319
Diabetes is an independent risk factor for coronary artery disease. For the occurrence of cardiovascular complications in diabetes, endothelial dysfunction plays an important role. Alterations of the endothelial-dependent coronary blood flow reserve have been shown to be based on the reduced bioavailability of nitric oxide (NO). Therefore, pharmacological approaches, which potentially reduce oxidative stress at the site of the endothelium, may be beneficial. As compared with other nitrates, the long-acting nitrate pentaerythritol tetranitrate (PETN) displays characteristics which may be beneficial for the treatment of endothelial dysfunction: apart from its vasodilatory and anti-ischemic properties, it has been shown to reduce endothelial dysfunction by activating the heme oxygenase-1 (HO-1) system. It also suppresses atherosclerotic vascular alterations. Other than regular nitrates, e.g., isosorbide dinitrate, drug tolerance is not observed. Treatment with pentaerythritol tetranitrate (PETN) may be advantageous in diabetic patients, who frequently present with endothelial dysfunction. Studies in diabetes assessing the effects of pentaerythritol tetranitrate (PETN) on cardiovascular function may display important effects on the active profile of PETN.
Clinical Research in Cardiology Supplements – Springer Journals
Published: Mar 12, 2010
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