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Endothelial function and oxidative stress in diabetes: active profile of the long-acting nitrate pentaerythritol tetranitrate (PETN)

Endothelial function and oxidative stress in diabetes: active profile of the long-acting nitrate... Diabetes is an independent risk factor for coronary artery disease. For the occurrence of cardiovascular complications in diabetes, endothelial dysfunction plays an important role. Alterations of the endothelial-dependent coronary blood flow reserve have been shown to be based on the reduced bioavailability of nitric oxide (NO). Therefore, pharmacological approaches, which potentially reduce oxidative stress at the site of the endothelium, may be beneficial. As compared with other nitrates, the long-acting nitrate pentaerythritol tetranitrate (PETN) displays characteristics which may be beneficial for the treatment of endothelial dysfunction: apart from its vasodilatory and anti-ischemic properties, it has been shown to reduce endothelial dysfunction by activating the heme oxygenase-1 (HO-1) system. It also suppresses atherosclerotic vascular alterations. Other than regular nitrates, e.g., isosorbide dinitrate, drug tolerance is not observed. Treatment with pentaerythritol tetranitrate (PETN) may be advantageous in diabetic patients, who frequently present with endothelial dysfunction. Studies in diabetes assessing the effects of pentaerythritol tetranitrate (PETN) on cardiovascular function may display important effects on the active profile of PETN. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Research in Cardiology Supplements Springer Journals

Endothelial function and oxidative stress in diabetes: active profile of the long-acting nitrate pentaerythritol tetranitrate (PETN)

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References (41)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Medicine & Public Health; Cardiac Surgery; Angiology; Internal Medicine; Diagnostic Radiology; Cardiology
ISSN
1861-0706
eISSN
1861-0714
DOI
10.1007/s11789-010-0015-x
Publisher site
See Article on Publisher Site

Abstract

Diabetes is an independent risk factor for coronary artery disease. For the occurrence of cardiovascular complications in diabetes, endothelial dysfunction plays an important role. Alterations of the endothelial-dependent coronary blood flow reserve have been shown to be based on the reduced bioavailability of nitric oxide (NO). Therefore, pharmacological approaches, which potentially reduce oxidative stress at the site of the endothelium, may be beneficial. As compared with other nitrates, the long-acting nitrate pentaerythritol tetranitrate (PETN) displays characteristics which may be beneficial for the treatment of endothelial dysfunction: apart from its vasodilatory and anti-ischemic properties, it has been shown to reduce endothelial dysfunction by activating the heme oxygenase-1 (HO-1) system. It also suppresses atherosclerotic vascular alterations. Other than regular nitrates, e.g., isosorbide dinitrate, drug tolerance is not observed. Treatment with pentaerythritol tetranitrate (PETN) may be advantageous in diabetic patients, who frequently present with endothelial dysfunction. Studies in diabetes assessing the effects of pentaerythritol tetranitrate (PETN) on cardiovascular function may display important effects on the active profile of PETN.

Journal

Clinical Research in Cardiology SupplementsSpringer Journals

Published: Mar 12, 2010

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