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Curr Allergy Asthma Rep (2017) 17:82 https://doi.org/10.1007/s11882-017-0751-9 BASIC AND APPLIED SCIENCE (I LEWKOWICH, SECTION EDITOR) 1 1,2 3 1,2 Jae Seok Jeong & So Ri Kim & Seong Ho Cho & Yong Chul Lee The Author(s) 2017. This article is an open access publication Abstract particularly corticosteroid-resistant severe disease, defining a Purpose of Review In this review, we will integrate recent novel concept of endotype-driven approach may be essential. knowledge on endoplasmic reticulum (ER) stress and allergy, Recently, stress responses originate from the endoplasmic re- thereby highlighting the therapeutic potential of ER stress in ticulum (ER) and the associated inflammatory molecular plat- the context of precision medicine for allergic diseases. form has been suggested as a crucial player of immune and Recent Findings Emerging evidence suggests that allergic inflammatory responses. This implies that ER stress-related diseases are very heterogeneous having numerous endotypes. pathways may represent a new endotype-driven therapeutic This leads to the new era of modern medicine, which assumes strategy in the treatment of allergic diseases. that a particular endotype-driven therapy, called precision . . medicine, would be more efficacious in a specific group of Keywords Precision medicine Biomarker Allergic . . . patients rather than in all
Current Allergy and Asthma Reports – Springer Journals
Published: Nov 8, 2017
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