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P. Ong, T. Ohtake, C. Brandt, I. Strickland, M. Boguniewicz, T. Ganz, R. Gallo, D. Leung (2002)
Endogenous antimicrobial peptides and skin infections in atopic dermatitis.The New England journal of medicine, 347 15
Lin Guo, K. Lim, Cristina Poduje, M. Daniel, J. Gunn, M. Hackett, Samuel Miller (1998)
Lipid A Acylation and Bacterial Resistance against Vertebrate Antimicrobial PeptidesCell, 95
M. Zanetti, R. Gennaro, D. Romeo (1995)
Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domainFEBS Letters, 374
S. Schaller-Bals, A. Schulze, R. Bals (2002)
Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection.American journal of respiratory and critical care medicine, 165 7
R. Gallo, Katherine Kim, M. Bernfield, C. Kozak, M. Zanetti, L. Merluzzi, R. Gennaro (1997)
Identification of CRAMP, a Cathelin-related Antimicrobial Peptide Expressed in the Embryonic and Adult Mouse*The Journal of Biological Chemistry, 272
A. Schmidtchen, I. Frick, E. Andersson, H. Tapper, L. Björck (2002)
Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL‐37Molecular Microbiology, 46
A. Cole, T. Hong, L. Boo, Tung Nguyen, Chengquan Zhao, G. Bristol, J. Zack, A. Waring, O. Yang, R. Lehrer (2002)
Retrocyclin: A primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1Proceedings of the National Academy of Sciences of the United States of America, 99
J. Nouwen, A. Belkum, H. Verbrugh (2001)
Determinants of Staphylococcus aureus nasal carriage.The Netherlands journal of medicine, 59 3
A. Bastian, H. Schäfer (2001)
Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro.Regulatory peptides, 101 1-3
D. Islam, L. Bandholtz, J. Nilsson, H. Wigzell, B. Christensson, B. Agerberth, G. Gudmundsson (2001)
Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulatorNature Medicine, 7
W. Shafer, X. Qu, A. Waring, R. Lehrer (1998)
Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family.Proceedings of the National Academy of Sciences of the United States of America, 95 4
Alexander Cole, Jishu Shi, A. Ceccarelli, Yong-Hwan Kim, A. Park, Tomas Ganz (2001)
Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds.Blood, 97 1
V. Nizet, T. Ohtake, X. Lauth, J. Trowbridge, Jennifer Rudisill, R. Dorschner, V. Pestonjamasp, J. Piraino, K. Huttner, R. Gallo (2001)
Innate antimicrobial peptide protects the skin from invasive bacterial infectionNature, 414
M. Zaiou, V. Nizet, R. Gallo (2003)
Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence.The Journal of investigative dermatology, 120 5
AJ Ouellette, MW Hsieh, DF Cano-Gauci (1994)
Mouse Paneth cell defensins: primary structures and antibacterial activities of cryptdin isoforms expressed in a single intestinal cryptInfect Immun, 62
K. Pütsep, G. Carlsson, H. Boman, M. Andersson (2002)
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation studyThe Lancet, 360
T. Guina, E. Yi, Houle Wang, M. Hackett, Samuel Miller (2000)
A PhoP-Regulated Outer Membrane Protease of Salmonella enterica Serovar Typhimurium Promotes Resistance to Alpha-Helical Antimicrobial PeptidesJournal of Bacteriology, 182
R. Dorschner, V. Pestonjamasp, Seema Tamakuwala, T. Ohtake, Jennifer Rudisill, V. Nizet, B. Agerberth, G. Gudmundsson, R. Gallo (2001)
Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus.The Journal of investigative dermatology, 117 1
Deborah O’Neil, E. Porter, D. Elewaut, G. Anderson, L. Eckmann, T. Ganz, M. Kagnoff (1999)
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.Journal of immunology, 163 12
R. Bals, Xiaorong Wang, Zhongren Wu, T. Freeman, V. Bafna, M. Zasloff, J. Wilson (1998)
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.The Journal of clinical investigation, 102 5
R. Gallo, M. Ono, T. Povsic, C. Page, E. Eriksson, M. Klagsbrun, M. Bernfield (1994)
Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds.Proceedings of the National Academy of Sciences of the United States of America, 91 23
Y. Chaly, E. Paleolog, T. Kolesnikova, I. Tikhonov, E. Petratchenko, N. Voitenok (2000)
Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells.European cytokine network, 11 2
A. Schmidtchen, I. Frick, L. Björck (2001)
Dermatan sulphate is released by proteinases of common pathogenic bacteria and inactivates antibacterial α‐defensinMolecular Microbiology, 39
R. Bals, D. Weiner, R. Meegalla, J. Wilson (1999)
Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model.The Journal of clinical investigation, 103 8
E. Lysenko, J. Gould, R. Bals, J. Wilson, J. Weiser (2000)
Bacterial Phosphorylcholine Decreases Susceptibility to the Antimicrobial Peptide LL-37/hCAP18 Expressed in the Upper Respiratory TractInfection and Immunity, 68
Jeffrey Smith, S. Travis, E. Greenberg, M. Welsh (1996)
Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface FluidCell, 85
(2002)
This study identified a receptor on host cells for human cathelicidin that might enable its chemotactic activity
(2013)
References Subscriptions Permissions Email Alerts Neutrophil Defensins Induce Histamine Secretion from Mast Cells: Mechanisms of Action
C. Chalekson, M. Neumeister, J. Jaynes (2002)
Improvement in burn wound infection and survival with antimicrobial peptide D2A21 (Demegel).Plastic and reconstructive surgery, 109 4
De Yang, Qian Chen, A. Schmidt, G. Anderson, Ji Wang, J. Wooters, Joost Oppenheim, O. Chertov (2000)
Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T CellsThe Journal of Experimental Medicine, 192
P. Park, G. Pier, M. Hinkes, M. Bernfield (2001)
Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulenceNature, 411
Giovanna Marchini, S. Lindow, H. Brismar, B. Ståbi, V. Berggren, A. Ulfgren, S-B Lonne-Rahm, B. Agerberth, G. Gudmundsson (2002)
The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosaBritish Journal of Dermatology, 147
Kimberly Conner, Karen Nern, Jennifer Rudisill, Terrence O’Grady, R. Gallo (2002)
The antimicrobial peptide LL-37 is expressed by keratinocytes in condyloma acuminatum and verruca vulgaris.Journal of the American Academy of Dermatology, 47 3
B. Schutte, J. Mitros, J. Bartlett, Jesse Walters, H. Jia, M. Welsh, T. Casavant, P. McCray (2002)
Discovery of five conserved β-defensin gene clusters using a computational search strategyProceedings of the National Academy of Sciences of the United States of America, 99
H. Zhang, G. Porro, N. Orzech, B. Mullen, M. Liu, Arthur Slutsky (2001)
Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion.American journal of physiology. Lung cellular and molecular physiology, 280 5
Andre Ouelleyite, Matthew Hsieh, T. Michael, Nosek, D. Cano-Gauci, K. Huttner, R. Buick', M. Selsted (1994)
Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoformsInfection and Immunity, 62
(2002)
The susceptibility of patients with atopic dermatitis to bacterial infections might be explained by a lack of expression of antimicrobial peptides
Carlos, Parra-Lopezl, Robert Lin, A. Aspedon, E. Groisman (1994)
A Salmonella protein that is required for resistance to antimicrobial peptides and transport of potassium.The EMBO Journal, 13
J. Ashitani, Hiroshi Mukae, T. Hiratsuka, M. Nakazato, Kenshi Kumamoto, Shigeru Matsukura (2001)
Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection.Chest, 119 4
A. Peschel, M. Otto, R. Jack, H. Kalbacher, G. Jung, F. Götz (1999)
Inactivation of the dlt Operon inStaphylococcus aureus Confers Sensitivity to Defensins, Protegrins, and Other Antimicrobial Peptides*The Journal of Biological Chemistry, 274
B. Agerberth, H. Gunne, Jakob Odeberg, P. Kogner, H. Boman, G. Gudmundsson (1995)
FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.Proceedings of the National Academy of Sciences of the United States of America, 92 1
J. Larrick, Jaehag Lee, Shihwin Ma, Xu Li, U. Francke, S. Wright, R. Balint (1996)
Structural, functional analysis and localization of the human CAP18 geneFEBS Letters, 398
A. Aprikyan, G. Carlsson, S. Stein, A. Oganesian, B. Fadeel, D. Dale, J. Palmblad, J. Henter (2003)
Retraction. Neutrophil elastase mutations in severe congenital neutropenia patients of the original Kostmann family.Blood, 103 2
D. Yang, O. Chertov, S. Bykovskaia, Q. Chen, M. Buffo, J. Shogan, M. Anderson, J. Schröder, J. Wang, O. Howard, J. Oppenheim (1999)
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.Science, 286 5439
Douglas Jones, C. Bevins (1992)
Paneth cells of the human small intestine express an antimicrobial peptide gene.The Journal of biological chemistry, 267 32
G. Morrison, F. Kilanowski, D. Davidson, J. Dorin (2002)
Characterization of the Mouse Beta Defensin 1, Defb1, Mutant Mouse ModelInfection and Immunity, 70
K. Brogden, V. Kalfa, M. Ackermann, D. Palmquist, P. McCray, B. Tack (2001)
The Ovine Cathelicidin SMAP29 Kills Ovine Respiratory Pathogens In Vitro and in an Ovine Model of Pulmonary InfectionAntimicrobial Agents and Chemotherapy, 45
P. Park, G. Pier, M. Preston, O. Goldberger, M. Fitzgerald, M. Bernfield (2000)
Syndecan-1 Shedding Is Enhanced by LasA, a Secreted Virulence Factor of Pseudomonas aeruginosa*The Journal of Biological Chemistry, 275
A Befus, C Mowat, M Gilchrist (1999)
Neutrophil defensins induce histamine secretion from mast cells: mechanisms of actionJ Immunol, 163
M. Bajaj‐Elliott, P. Fedeli, G. Smith, P. Domizio, L. Maher, R. Ali, A. Quinn, M. Farthing (2002)
Modulation of host antimicrobial peptide (β-defensins 1 and 2) expression during gastritisGut, 51
G. Gudmundsson, G. Gudmundsson, B. Agerberth, B. Agerberth, J. Odeberg, T. Bergman, B. Olsson, R. Salcedo (1996)
The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.European journal of biochemistry, 238 2
JS Gunn, SS Ryan, JC Velkinburgh (2000)
Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimuriumInfect Immun, 68
K. Zarember, S. Katz, B. Tack, L. Doukhan, J. Weiss, P. Elsbach (2002)
Host Defense Functions of Proteolytically Processed and Parent (Unprocessed) Cathelicidins of Rabbit GranulocytesInfection and Immunity, 70
J. Lehmann, M. Retz, J. Harder, M. Krams, U. Kellner, J. Hartmann, Kerstin Hohgräwe, Uta Raffenberg, M. Gerber, T. Loch, K. Weichert‐Jacobsen, M. Stöckle (2002)
Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infectionBMC Infectious Diseases, 2
M. Ortega, Tomas Ganz, Stephen Milner (2000)
Human beta defensin is absent in burn blister fluid.Burns : journal of the International Society for Burn Injuries, 26 8
De Yang, O. Chertov, S. Bykovskaia, Qian Chen, M. Buffo, J. Shogan, M. Anderson, J. Schröder, Ji Wang, O. Howard, Joost Oppenheim (1999)
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6Science, 286
A. Ceccarelli, A. Cole, A. Park, S. Tahk, D. Yoshioka, T. Ganz (2001)
Therapeutic effect of a pig-derived peptide antibiotic on porcine wound infections.Comparative medicine, 51 1
N. Uehara, A. Yagihashi, K. Kondoh, N. Tsuji, T. Fujita, H. Hamada, N. Watanabe (2003)
Human beta-defensin-2 induction in Helicobacter pylori-infected gastric mucosal tissues: antimicrobial effect of overexpression.Journal of medical microbiology, 52 Pt 1
A. Nardo, A. Vitiello, R. Gallo (2003)
Cutting Edge: Mast Cell Antimicrobial Activity Is Mediated by Expression of Cathelicidin Antimicrobial Peptide 1The Journal of Immunology, 170
W. Lushbaugh, R. Finley, A Blossom, A. Banga, P. Shah, J. Cleary, J. Jaynes (2000)
Use of intravaginal microbicides to prevent acquisition of Trichomonas vaginalis infection in Lactobacillus-pretreated, estrogenized young mice.The American journal of tropical medicine and hygiene, 63 5-6
O. Sørensen, P. Follin, A. Johnsen, J. Calafat, G. Tjabringa, P. Hiemstra, N. Borregaard (2001)
Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3.Blood, 97 12
M. Goldman, G. Anderson, Ethan Stolzenberg, U. Kari, M. Zasloff, James Wilson (1997)
Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic FibrosisCell, 88
B. Agerberth, Jong-Youn Lee, T. Bergman, M. Carlquist, H. Boman, V. Mutt, H. Jörnvall (1991)
Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides.European journal of biochemistry, 202 3
R. Cunliffe, M. Kamal, F Rose, P James, Y. Mahida (2002)
Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa.Journal of clinical pathology, 55 4
F. Niyonsaba, K. Iwabuchi, A. Someya, M. Hirata, H. Matsuda, H. Ogawa, I. Nagaoka (2002)
A cathelicidin family of human antibacterial peptide LL‐37 induces mast cell chemotaxisImmunology, 106
A. Peschel, A. Peschel, R. Jack, M. Otto, L. Collins, Petra Staubitz, G. Nicholson, H. Kalbacher, W. Nieuwenhuizen, G. Jung, A. Tarkowski, K. Kessel, J. Strijp (2001)
Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with l-LysineThe Journal of Experimental Medicine, 193
H. Wiesenfeld, R. Heine, M. Krohn, Sharon Hillier, Antonio Amortegui, Michael Nicolazzo, Richard L. Sweet (2002)
Association between elevated neutrophil defensin levels and endometritis.The Journal of infectious diseases, 186 6
J. Aarbiou, M. Ertmann, S. Wetering, P. Noort, D. Rook, K. Rabe, S. Litvinov, J. Krieken, W. Boer, P. Hiemstra (2002)
Human neutrophil defensins induce lung epithelial cell proliferation in vitroJournal of Leukocyte Biology, 72
C. Moser, D. Weiner, E. Lysenko, R. Bals, J. Weiser, James Wilson (2002)
β-Defensin 1 Contributes to Pulmonary Innate Immunity in MiceInfection and Immunity, 70
J. Heilborn, M. Nilsson, G. Kratz, G. Weber, O. Sørensen, N. Borregaard, M. Ståhle-Bäckdahl (2003)
The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium.The Journal of investigative dermatology, 120 3
Daniel Carothers, Scott Graham, H. Jia, M. Ackermann, B. Tack, P. McCray (2001)
Production of β-Defensin Antimicrobial Peptides by Maxillary Sinus MucosaAmerican Journal of Rhinology & Allergy, 15
A. Bastian, H. Schäfer (2001)
Human α-defensin 1 (HNP-1) inhibits adenoviral infection in vitroRegulatory Peptides, 101
M. Zanetti, L. Litteri, G. Griffiths, R. Gennaro, D. Romeo (1991)
Stimulus-induced maturation of probactenecins, precursors of neutrophil antimicrobial polypeptides.Journal of immunology, 146 12
AM Cole, S Tahk, A Oren (2001)
Determinants of Staphylococcus aureus nasal carriageClin Diagn Lab Immunol, 8
Antimicrobial peptides are diverse and evolutionarily ancient molecules produced by all living organisms. Peptides belonging to the cathelicidin and defensin gene families exhibit an immune strategy as they defend against infection by inhibiting microbial survival, and modify hosts through triggering tissue-specific defense and repair events. A variety of processes have evolved in microbes to evade the action of antimicrobial peptides, including the ability to degrade or inactivate antimicrobial peptides, or suppress host production of the peptide in response to infection. Animal models and clinical investigations have shown that an absence of cathelicidin or defensin antimicrobials can lead to disease. In this article, we review important recent advances in understanding the biology of antimicrobial peptides and their role in normal immunity and human disease.
Current Allergy and Asthma Reports – Springer Journals
Published: May 30, 2003
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