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- Copyright © Zoological Society, Kolkata, India 2021
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- 0373-5893
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- DOI
- 10.1007/s12595-021-00406-1
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Abstract
Very often endocrine disrupting chemicals are heterogeneous combination of chemical compounds which mainly target the body’s endocrine system. These can exhibit their effects via different mechanisms of action by intervening with hormone receptors, signalling transduction pathway, hormonal biosynthesis, transport, distribution, metabolism process and epigenetic modifications. Exposure to endocrine disruptors can cause a variety of reproductive health problems, such as changes in sex hormone levels, infertility, and ultimately cellular damage to the reproductive organs. This overview covers the different modes of action by which these agents interact with the body's endocrine system. However, the main objective is to ascertain the negative biological effects of some dominant endocrine disruptors, for example bisphenols, dioxins, pesticides, phthalates, drugs and phytoestrogens on female reproductive organs when used to induce reproductive health risks related to early puberty, altered menstrual cycle, altered ovarian steroidogenesis and folliculogenesis, polycystic ovary syndrome and endometriosis based on various in vitro, in vivo and clinical examinations.
Journal
Proceedings of the Zoological Society – Springer Journals
Published: Dec 1, 2021
Keywords: Endocrine disrupting chemicals; Mode of actions; Female infertility; PCOS; Endometriosis