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18 (4H, m, ArH), 8.42 (2H, s, NH 2 ), 10.52 (1H, s, NH)
Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
Two new categories of fused pyridines include 2H-thiazolo[3,2-a]pyridine-6-carbohydrazides and 2H-oxazolo[3,2-a]pyridine-6-carbohydrazides have been successfully synthesized via five-component cascade reactions using 9-fluorenone, cyanoacetohydrazide, 1,1-bis(methylthio)-2-nitroethene, aromatic aldehydes and cysteamine hydrochloride or ethanol amine as starting materials. This new approach involves a subsequence of key steps: N,S-acetal or N,O-acetal formation, Knoevenagel condensation, Michael addition, tautomerization and N-cyclization. It also has some advantages, such as convenience of operation, tolerance of a wide diversity of functional groups, use of green solvent and ease of purification by washing the crude products with ethanol.Graphical abstract[graphic not available: see fulltext]
Molecular Diversity – Springer Journals
Published: Apr 1, 2023
Keywords: Thiazolopyridine; Oxazolopyridine; Cyanoacetohydrazide; Nitroketene acetal; One-pot reaction
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