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- Publisher
- Springer Journals
- Copyright
- Copyright © 2015 by The Author(s)
- Subject
- Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
- ISSN
- 1175-3277
- eISSN
- 1179-187X
- DOI
- 10.1007/s40256-015-0156-x
- pmid
- 26691333
- Publisher site
- See Article on Publisher Site
Abstract
Am J Cardiovasc Drugs (2016) 16:129–138 DOI 10.1007/s40256-015-0156-x ORIGINAL RESEARCH ARTICLE Efficacy and Safety Study of Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide Combination Therapy in Patients with Hypertension Not Controlled with Olmesartan Medoxomil and Hydrochlorothiazide Combination Therapy: Results of a Randomized, Double-Blind, Multicenter Trial 1 1 2 3 • • • • Il Suk Sohn Chong-Jin Kim Byung-Hee Oh Taek-Jong Hong 4 5 6 • • • Chang-Gyu Park Byung-Soo Kim Woo-Baek Chung For the Investigators Published online: 21 December 2015 The Author(s) 2015. This article is published with open access at Springerlink.com Abstract [130/80 mmHg with diabetes or chronic kidney disease] Background This study was to evaluate the efficacy and with 4-week dual FDC therapy (OM/HCTZ 20/12.5). The safety of triple fixed-dose combination (FDC) therapy with patients were randomized to receive either OM/AML/ olmesartan medoxomil (OM) 20 mg, amlodipine (AML) HCTZ 20/5/12.5 or OM/HCTZ 20/12.5 once daily for 5 mg, and hydrochlorothiazide (HCTZ) 12.5 mg (OM/ 8 weeks. At the end of 8 weeks, patients with uncontrolled AML/HCTZ 20/5/12.5) in Korean patients with moderate BP were assigned to receive either OM/AML/HCTZ 40/5/ hypertension not controlled with dual FDC therapy (OM/ 12.5 or OM/AML/HCTZ 20/5/12.5 in an additional 8-week HCTZ
Journal
American Journal of Cardiovascular Drugs – Springer Journals
Published: Dec 21, 2015