Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Staub, A. Meyerhans, B. Bundi (2006)
Prediction of cardiovascular morbidity and mortality: comparison of the internal carotid artery resistive index with the common carotid artery intima-media thicknessStroke, 37
R.J. Bisoendial, G.K. Hovingh, E. Groot (2002)
Measurement of subclinical atherosclerosis: beyond risk factor assessmentCurr Opin Lipidol, 13
S.E. Nissen, E.M. Tuzcu, P. Schoenhagen (2004)
Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trialJAMA, 291
S.E. Nissen, S.J. Nicholls, I. Sipahi (2006)
Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trialJAMA, 295
R.R. Sankatsing, E. Groot, J.W. Jukema (2005)
Surrogate markers for atherosclerotic diseaseCurr Opin Lipidol, 16
K. Croce, P. Libby (2007)
Intertwining of thrombosis and inflammation in atherosclerosisCurr Opin Hematol, 14
S.M. Grundy, J.I. Cleeman, C.N. Merz (2004)
Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelinesCirculation, 110
P.M. Ridker, C.H. Hennekens, J.E. Buring (2000)
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in womenN Engl J Med, 342
P.J. Touboul, M.G. Hennerici, S. Meairs (2007)
Mannheim carotid intima-media thickness consensus (2004–2006). An update on behalf of the advisory board of the 3rd and 4th Watching the Risk Symposium 13th and 15th European stroke conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006Cerebrovasc Dis, 23
B.G. Brown, X.-Q. Zhao (2007)
Is intravascular ultrasound the gold standard surrogate for clinically relevant atherosclerosis progression?J Am Coll Cardiol, 49
H.K. Saini, Y.J. Xu, A.S. Arneja (2005)
Pharmacological basis of different targets for the treatment of atherosclerosisJ Cell Mol Med, 9
C. Berry, P.L. L’Allier, J. Gregoire (2008)
Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progressionCirculation, 115
(2002)
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final reportCirculation, 106
H.S. Kruth (2001)
Lipoprotein cholesterol and atherosclerosisCurr Mol Med, 1
M.R. Law, N.J. Wald, S.G. Thompson (1994)
By how much and how quickly does reduction in serum cholesterol lower risk of ischemic heart disease?BMJ, 308
D. Gordon, J.L. Probstfield, R.J. Garrison (1989)
High density lipoprotein cholesterol and cardiovascular disease: four prospective American studiesCirculation, 79
E.M. Tuzcu, S.J. Nicholls (2007)
Statins: targeting inflammation by lowering lowdensity lipoproteinJ Am Coll Cardiol, 49
A. Sachdeva, C.P. Cannon, P.C. Deedwania (2009)
Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The GuidelinesAm Heart J, 157
A correlation exists between circulating levels of low-density lipoprotein cholesterol (LDL-C) and risk of cardiovascular disease (CVD). Evidence from clinical trials indicates that reducing LDL-C levels can result in beneficial clinical outcomes in patients at risk of CVD and in high-risk patients with clinical symptoms of CVD. Lipid-lowering agents, of which HMG-CoA reductase inhibitors (statins) are the most effective, protect against the vascular changes seen in the development of atherosclerotic plaque formation. Clinical trials assessing the effects of statins on coronary atherosclerosis using quantitative coronary angiography or intravascular ultrasound showed that statins can reduce progression or even cause regression of atherosclerotic plaque. This improvement of vascular structure after statin treatment is correlated with reductions in LDL-C levels. This appears to be the principal mechanism by which statin therapy reduces cardiovascular risk, with emerging evidence for statin-mediated changes in high-density lipoprotein and C-reactive protein levels contributing to modification of the atherosclerotic plaque.
American Journal of Cardiovascular Drugs – Springer Journals
Published: Aug 17, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.