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- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Springer-Verlag London Limited
- Subject
- Medicine & Public Health; Pathology; Hematology; Oncology
- eISSN
- 1618-565X
- DOI
- 10.1007/s00580-005-0545-7
- Publisher site
- See Article on Publisher Site
Abstract
Since leukocytes have the potential to produce oxygen free radicals that damage biomolecules, we have evaluated the influence of thiolic antioxidants (glutathione, N-acetylcysteine and thioproline) on selected hematoimmunological characteristics. We used peritoneal leukocytes incubated at 0.5, 1.0 and 5.0 mM concentration of antioxidants. Following thiol treatment, we found a stimulation of phagocytic activity, and markedly decreased incidence of programmed cell death of peritoneal leukocytes, both basal and induced by H2O2. Low concentrations of thiolic compounds also increased the activity of catalase, glutathione peroxidase and glutathione reductase. On the contrary, only the highest concentration of N-acetylcysteine and thioproline reduced superoxide dismutase activity. Tested antioxidants can lead to a decrease of the oxidative stress, and could provide a nutritional benefit for evaluated immunological characteristics.
Journal
Comparative Clinical Pathology – Springer Journals
Published: Apr 9, 2005