Access the full text.
Sign up today, get DeepDyve free for 14 days.
(2007)
Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female
(2003)
Excisional wound healing. In: Dipietro LA, Burns AL (eds) Methods in molecular medicine: wound healing methods and protocols
Haihong Li, Xiaobing Fu, Lei Zhang, Qing-jun Huang, Z. Wu, T. Sun (2008)
Research of PDGF-BB gel on the wound healing of diabetic rats and its pharmacodynamics.The Journal of surgical research, 145 1
M. Hardman, E. Emmerson, L. Campbell, G. Ashcroft (2008)
Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice.Endocrinology, 149 2
G. Ashcroft, S. Mills, K. Lei, L. Gibbons, M. Jeong, Marisu Taniguchi, M. Burow, M. Horan, S. Wahl, T. Nakayama (2003)
Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.The Journal of clinical investigation, 111 9
M. Rajabi, F. Rajabi (2007)
THE EFFECT OF ESTROGEN ON WOUND HEALING IN RATS
Kumar Ganesan, G. Banu, A. Murugesan, M. Pandian (2007)
Antihyperglycaemic and antiperoxidative effect of Helicteres isora L. bark extracts in streptozotocin-induced diabetic ratsJournal of Applied Biomedicine, 5
S. Verdier-Sévrain, M. Yaar, J. Cantatore, A. Traish, B. Gilchrest (2004)
Estradiol induces proliferation of keratinocytes via receptor‐ mediated mechanismsThe FASEB Journal, 18
(2005)
Hormonal influences on wound healing. Wounds
A. Singer, R. Clark (1999)
Cutaneous wound healing.The New England journal of medicine, 341 10
G. Ashcroft, J. Ashworth (2003)
Potential Role of Estrogens in Wound HealingAmerican Journal of Clinical Dermatology, 4
E. Pirilä, N. Ramamurthy, P. Maisi, S. Mcclain, A. Kucine, J. Wahlgren, L. Golub, T. Salo, T. Sorsa (2001)
Wound healing in ovariectomized rats: effects of chemically modified tetracycline (CMT-8) and estrogen on matrix metalloproteinases -8, -13 and type I collagen expression.Current medicinal chemistry, 8 3
Deborah Doxey, May Ng, Russell Dill, Anthony Iacopino (1995)
Platelet-derived growth factor levels in wounds of diabetic rats.Life sciences, 57 11
DD Kakagia, KJ Kazakos, KC Xarchas (2007)
Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcersJ Diab Complications, 21
P. Gál, T. Toporcer, B. Vidinský, M. Mokry, T. Grendel, M. Novotný, J. Sokolský, N. Bobrov, S. Toporcerová, J. Sabó, Š. Mozes̆ (2008)
Postsurgical administration of estradiol benzoate decreases tensile strength of healing skin wounds in ovariectomized rats.The Journal of surgical research, 147 1
E. Pirilä, M. Parikka, N. Ramamurthy, P. Maisi, S. Mcclain, A. Kucine, T. Tervahartiala, K. Prikk, L. Golub, T. Salo, T. Sorsa (2002)
Chemically modified tetracycline (CMT‐8) and estrogen promote wound healing in ovariectomized rats: Effects on matrix metalloproteinase‐2, membrane type 1 matrix metalloproteinase, and laminin‐5 γ2‐chainWound Repair and Regeneration, 10
G. Ashcroft, J. Dodsworth, E. Boxtel, R. Tarnuzzer, M. Horan, G. Schultz, M. Ferguson (1997)
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levelsNature Medicine, 3
M. Rajabi, F. Rajabi, P. Dehnavi, Mitra Heidarpour (2008)
Estrogen Accelerates Wound Angiogenesis In Ratsiranian journal of pathology, 3
S Frank, H Kämpfer (2003)
Methods in molecular medicine: wound healing methods and protocols. Vol 78
Patrik Velander, C. Theopold, O. Bleiziffer, J. Bergmann, H. Svensson, Yao Feng, E. Eriksson (2009)
Cell suspensions of autologous keratinocytes or autologous fibroblasts accelerate the healing of full thickness skin wounds in a diabetic porcine wound healing model.The Journal of surgical research, 157 1
Z. Qiu, A. Kwon, Y. Kamiyama (2007)
Effects of plasma fibronectin on the healing of full-thickness skin wounds in streptozotocin-induced diabetic rats.The Journal of surgical research, 138 1
R. Lobmann, C. Zemlin, M. Motzkau, K. Reschke, H. Lehnert (2006)
Expression of matrix metalloproteinases and growth factors in diabetic foot wounds treated with a protease absorbent dressing.Journal of diabetes and its complications, 20 5
T. Simoncini, P. Mannella, A. Genazzani (2006)
Rapid Estrogen Actions in the Cardiovascular SystemAnnals of the New York Academy of Sciences, 1089
A. Terranova (1991)
The Effects of Diabetes Mellitus on Wound HealingPlastic Surgical Nursing, 11
S. Frank, H. Kämpfer (2003)
Excisional Wound HealingMethods in molecular medicine, 78
C. Engeland, Bahareh Sabzehei, P. Marucha (2009)
Sex hormones and mucosal wound healingBrain, Behavior, and Immunity, 23
M. Komesu, Marcelo Tanga, Kemli Buttros, C. Nakao (2004)
Effects of acute diabetes on rat cutaneous wound healing.Pathophysiology : the official journal of the International Society for Pathophysiology, 11 2
S. Enoch, D. Leaper (2005)
Basic science of wound healingSurgery (oxford), 26
W. Marhoffer, M. Stein, E. Maeser, K. Federlin (1992)
Impairment of Polymorphonuclear Leukocyte Function and Metabolic Control of DiabetesDiabetes Care, 15
D. Kakagia, K. Kazakos, K. Xarchas, M. Karanikas, G. Georgiadis, G. Tripsiannis, C. Manolas (2007)
Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial.Journal of diabetes and its complications, 21 6
A. Asilian, R. Tavakolikia, Fariba. Iraji, M. Ghasemi (2001)
TOPICAL ESTROGEN IN WOUND HEALING: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL ON YOUNG HEALTHY PEOPLEJournal of Research in Medical Sciences, 6
Karin Hehenberger, J. Heilborn, K. Brismar, A. Hansson (1998)
Inhibited proliferation of fibroblasts derived from chronic diabetic wounds and normal dermal fibroblasts treated with high glucose is associated with increased formation of L‐lactateWound Repair and Regeneration, 6
J. Brosens, E. Lam, M. Parker (2006)
Inflammation and Sex Steroid Receptors: A Motif for ChangeCell, 124
(2005)
Hormonal influences on wound healing
M. Calvin (2000)
Oestrogens and wound healing.Maturitas, 34 3
B. Garmy-Susini, E. Delmas, P. Gourdy, M. Zhou, C. Bossard, B. Bugler, F. Bayard, A. Krust, A. Prats, T. Doetschman, H. Prats, J. Arnal (2004)
Role of Fibroblast Growth Factor-2 Isoforms in the Effect of Estradiol on Endothelial Cell Migration and ProliferationCirculation Research: Journal of the American Heart Association, 94
C. Gargett, M. Zaitseva, K. Bucak, S. Chu, P. Fuller, P. Rogers (2002)
17β-Estradiol Up-Regulates Vascular Endothelial Growth Factor Receptor-2 Expression in Human Myometrial Microvascular Endothelial Cells: Role of Estrogen Receptor-α and -βThe Journal of Clinical Endocrinology and Metabolism, 87
Ian Darby, T. Bisucci, T. Hewitson, Donald MacLellan (1997)
Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice.The international journal of biochemistry & cell biology, 29 1
J. Labat-robert, M. Leutenegger, G. Llopis, Y. Ricard, J. Derouette (1984)
Plasma and tissue fibronectin in diabetes.Clinical physiology and biochemistry, 2 1
R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, H. Lehnert (2002)
Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patientsDiabetologia, 45
T Simoncini, P Mannella, AR Genazzani (2006)
Rapid estrogen actions in the cardiovascular systemAnn NY Acad Sci, 1089
MO Desiree, JP Tania, MD philipse (2006)
Sex hormones and wound healingWounds, 18
G. Ashcroft, G. Ashcroft, T. Greenwell-Wild, M. Horan, S. Wahl, M. Ferguson (1999)
Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response.The American journal of pathology, 155 4
In this research, the possible effects of systemic and topical estrogen were investigated on wound healing in normal and diabetic male rats. One hundred and ten male Wistar rats were divided into two groups (normal and diabetic). After induction of diabetes by streptozotocin in rats, each group was divided into three subgroups (control, sham, and test). A round full-thickness skin excision with 1.5-cm diameter was performed on the dorsum of each rat. In systemic use, 10 μG/SC of estradiol benzoate was administered daily to test subgroups for 28 days. In topical use, the wounds in the test subgroup rats were treated with a daily topical dose of 0.5 mg estrogen. Sham subgroup was injected with placebo and the control subgroup received nothing. The area of the wounds was measured by using scion image software at 3, 5, 7, 14, 21, 28 days. Histopathologic evaluation was assessed semi-quantitatively for different parameters including re-epithelization, neoangiogenesis, and granulation tissue formation. In macroscopic study, estradiol subgroups (systemic and topical application) wound healing had considerable changes in day 7 (p < 0.05). Histopathologic evaluation was revealed increased vascularization, re-epithelialization in estradiol subgroups. So, this research expressed that systemic and topical estrogen can improve the impaired healing of diabetic wounds.
Comparative Clinical Pathology – Springer Journals
Published: Jan 5, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.