Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effects of sodium and potassium concentrations and pH on equine erythrocyte volume and deformability

Effects of sodium and potassium concentrations and pH on equine erythrocyte volume and deformability During strenuous exercise, equine erythrocyte deformability is transiently decreased. Decreased deformability is associated with increased cell volume, decreased cell density and increased intracellular sodium, potassium and chloride concentrations. To better understand these changes, we attempted to reproduce exercise-associated changes in erythrocytes in vitro by adjusting plasma sodium, potassium and pH to levels which occur during racing activity. Increasing plasma sodium to 145 meq/1 and plasma potassium to 8 meq/1 resulted in decreased erythrocyte filterability, increased cell volume, and increased intracellular sodium, potassium and chloride. Incubation of erythrocytes with frusemide and bumetanide, but not ouabain or [(dihydroindenyl)oxy]alkanoic acid (DIOA), attenuated these changes. Decreasing plasma pH to 7.0 also decreased erythrocyte filterability, increased cell volume, and increased intracellular concentrations of sodium, potassium and chloride. Ouabain, but not frusemide or bumetanide, prevented the decrease infilterability and attenuated the increase in intracellular sodium. Addition of DIOA exacerbated the effect of pH on erythrocyte filterability. Therefore, exercise-associated changes in erythrocyte deformability, size and electrolyte concentration can be reproduced in vitro by increasing plasma sodium and potassium concentrations and by decreasing pH. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Effects of sodium and potassium concentrations and pH on equine erythrocyte volume and deformability

Comparative Clinical Pathology , Volume 7 (1) – Dec 7, 2004

Loading next page...
 
/lp/springer-journals/effects-of-sodium-and-potassium-concentrations-and-ph-on-equine-8Lgy1OnUgS

References (35)

Publisher
Springer Journals
Copyright
Copyright © 1997 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Hematology; Oncology
eISSN
1433-2973
DOI
10.1007/BF01320997
Publisher site
See Article on Publisher Site

Abstract

During strenuous exercise, equine erythrocyte deformability is transiently decreased. Decreased deformability is associated with increased cell volume, decreased cell density and increased intracellular sodium, potassium and chloride concentrations. To better understand these changes, we attempted to reproduce exercise-associated changes in erythrocytes in vitro by adjusting plasma sodium, potassium and pH to levels which occur during racing activity. Increasing plasma sodium to 145 meq/1 and plasma potassium to 8 meq/1 resulted in decreased erythrocyte filterability, increased cell volume, and increased intracellular sodium, potassium and chloride. Incubation of erythrocytes with frusemide and bumetanide, but not ouabain or [(dihydroindenyl)oxy]alkanoic acid (DIOA), attenuated these changes. Decreasing plasma pH to 7.0 also decreased erythrocyte filterability, increased cell volume, and increased intracellular concentrations of sodium, potassium and chloride. Ouabain, but not frusemide or bumetanide, prevented the decrease infilterability and attenuated the increase in intracellular sodium. Addition of DIOA exacerbated the effect of pH on erythrocyte filterability. Therefore, exercise-associated changes in erythrocyte deformability, size and electrolyte concentration can be reproduced in vitro by increasing plasma sodium and potassium concentrations and by decreasing pH.

Journal

Comparative Clinical PathologySpringer Journals

Published: Dec 7, 2004

There are no references for this article.