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K. Khavandi, M. Arunakirinathan, A. Greenstein, A. Heagerty (2013)
Retinal Arterial Hypertrophy: the New LVH?Current Hypertension Reports, 15
A. Antonopoulos, M. Margaritis, Regent Lee, K. Channon, C. Antoniades (2012)
Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical TrialsCurrent Pharmaceutical Design, 18
J. Mckenney (2005)
Efficacy and safety of rosuvastatin in treatment of dyslipidemia.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 62 10
L. Hubbard, Rosemary Brothers, William King, L. Clegg, R. Klein, L. Cooper, A. Sharrett, M. Davis, Jianwen Cai (1999)
Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study.Ophthalmology, 106 12
Cong Sun, Jie-Jin Wang, D. Mackey, T. Wong (2009)
Retinal vascular caliber: systemic, environmental, and genetic associations.Survey of ophthalmology, 54 1
P. Ridker, E. Danielson, F. Fonseca, J. Genest, A. Gotto, J. Kastelein, W. Koenig, P. Libby, A. Lorenzatti, Jean Macfadyen, B. Nordestgaard, J. Shepherd, J. Willerson, R. Glynn (2008)
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.The New England journal of medicine, 359 21
M. Knudtson, B. Klein, R. Klein, Tien Wong, L. Hubbard, Kristine Lee, S. Meuer, C. Bulla (2003)
Variation associated with measurement of retinal vessel diameters at different points in the pulse cycleBritish Journal of Ophthalmology, 88
J. Parr, G. Spears (1974)
Mathematic relationships between the width of a retinal artery and the widths of its branches.American journal of ophthalmology, 77 4
Shuang Wang, Liang Xu, J. Jonas, T. Wong, T. Cui, Yi-bin Li, Y. Wang, Q. You, Hua Yang, Cong Sun (2009)
Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study.Ophthalmology, 116 12
P. Ridker, E. Danielson, Francisco Fonseca, J. Genest, A. Gotto, J. Kastelein, W. Koenig, P. Libby, A. Lorenzatti, Jean Macfadyen, B. Nordestgaard, J. Shepherd, J. Willerson, R. Glynn (2009)
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trialThe Lancet, 373
M. Sasaki, Wei Gan, R. Kawasaki, L. Hodgson, Kim Lee, T. Wong, E. Lamoureux, L. Robman, R. Guymer (2013)
Effect of simvastatin on retinal vascular caliber: the Age‐Related Maculopathy Statin StudyActa Ophthalmologica, 91
S. Ji (2010)
Measurement of retinal arteriole-to-venule ratio in normal eyes of Han nationalityRecent Advances in Ophthalmology
N. Terai, E. Spoerl, S. Fischer, K. Hornykewycz, M. Haustein, J. Haentzschel, L. Pillunat (2011)
Statins affect ocular microcirculation in patients with hypercholesterolaemiaActa Ophthalmologica, 89
T. Nagaoka, T. Hein, A. Yoshida, L. Kuo (2007)
Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways.Investigative ophthalmology & visual science, 48 2
M. Ikram, F. Jong, Johannes Vingerling, J. Witteman, A. Hofman, M. Breteler, P. Jong (2004)
Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study.Investigative ophthalmology & visual science, 45 7
横山 光宏, R. Ross (1998)
Atherosclerosis is an Inflammatory DiseaseJapanese Circulation Journal-english Edition, 62
Kadir Ağladıoğlu, G. Pekel, V. Çıtışlı, R. Yağcı (2015)
Choroidal thickness and retinal vascular caliber correlations with internal carotid artery Doppler variablesJournal of Clinical Ultrasound, 43
T. Nagaoka, A. Takahashi, E. Sato, N. Izumi, T. Hein, L. Kuo, A. Yoshida (2006)
Effect of systemic administration of simvastatin on retinal circulation.Archives of ophthalmology, 124 5
Williams Kj, I. Tabas (1999)
Atherosclerosis--an inflammatory disease.The New England journal of medicine, 340 24
O. Tamai, H. Matsuoka, H. Itabe, Y. Wada, K. Kohno, T. Imaizumi (1997)
Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans.Circulation, 95 1
R. Rosenson (2003)
Rosuvastatin: a new inhibitor of HMG-CoA reductase for the treatment of dyslipidemiaExpert Review of Cardiovascular Therapy, 1
K. Ikram, Yi-Ting Ong, C. Cheung, T. Wong (2012)
Retinal Vascular Caliber Measurements: Clinical Significance, Current Knowledge and Future PerspectivesOphthalmologica, 229
J. Parr, G. Spears (1974)
General caliber of the retinal arteries expressed as the equivalent width of the central retinal artery.American journal of ophthalmology, 77 4
K. McGeechan, G. Liew, P. Macaskill, L. Irwig, R. Klein, A. Sharrett, B. Klein, Jie Wang, Jie Wang, L. Chambless, Tien Wong, Tien Wong (2008)
Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] Study).The American journal of cardiology, 102 1
Harry Leung, Jie Wang, E. Rochtchina, Tien Wong, Ronald Klein, Paul Mitchell (2005)
Dyslipidaemia and microvascular disease in the retinaEye, 19
M. Bayerle‐Eder, G. Fuchsjäger‐Mayrl, A. Sieder, E. Polska, M. Roden, T. Stulnig, M. Bischof, W. Waldhäusl, L. Schmetterer, M. Wolzt (2002)
Effect of pravastatin on responsiveness to N-monomethyl-L-arginine in patients with hypercholesterolaemia.Atherosclerosis, 160 1
N. Stone, Jennifer Robinson, A. Lichtenstein, C. Noel, B. Merz, D. Lloyd‐Jones, C. Blum, P. Mcbride, R. Eckel, F. Schwartz, A. Goldberg, Susan Shero, Rn, D. Gordon, Sidney Smith, D. Levy, K. Watson, P. Wilson, Karen Eddleman, N. Jarrett, K. Labresh, Lev Nevo, J. Wnek, Jeffrey Anderson, J. Halperin, N. Albert, J. Hochman, B. Bozkurt, R. Kovacs, R. Brindis, Macc Ohman, L. Curtis, S. Pressler, D. DeMets, F. Sellke, R. Guyton, W. Shen, G. Tomaselli, Stone Nj, Robinson J, Lichtenstein Ah, M. Bairey, Blum Cn, Eckel Cb, Goldberg Rh, Gordon Ac, Levy D, Lloyd-Jones Dm, P. Mcbride, Js Schwartz, Shero St, Smith Sc, W. Wilson (2014)
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.Circulation, 129 25 Suppl 2
E. Stein, K. Strutt, H. Southworth, P. Diggle, Elinor Miller (2003)
Comparison of rosuvastatin versus atorvastatin in patients with heterozygous familial hypercholesterolemia.The American journal of cardiology, 92 11
D. Betteridge, J. Gibson, P. Sager (2007)
Comparison of effectiveness of rosuvastatin versus atorvastatin on the achievement of combined C-reactive protein (<2 mg/L) and low-density lipoprotein cholesterol (< 70 mg/dl) targets in patients with type 2 diabetes mellitus (from the ANDROMEDA study).The American journal of cardiology, 100 8
Introduction Atherosclerosis erodes large elastic arteries and damages peripheral small vessels. Evaluating retinal vessel caliber enables exploration of the effect of improving microcirculation with statins. Objective We investigated whether rosuvastatin therapy improves retinal vasculature in hypercholesterolemic patients with a low-to-moderate risk of coronary artery disease (CAD). Methods This was a prospective, open-label, randomized study in which 127 patients were enrolled and randomized (ratio 1:1) into rosuvastatin and control groups. Results Rosuvastatin increased retinal arteriolar calibers by 3.560 µm at 12 months, decreased retinal venular calibers by 3.110 µm at 6 months and by 5.860 µm at 12 months, and increased the artery–vein ratio (AVR) by 2.68% at 6 months and by 5.90% at 12 months. Meanwhile, in the control group, retinal arteriolar calibers decreased by 1.110 µm at 12 months, retinal venular calibers increased by 1.020 µm at 6 months and by 1.04 µm at 12 months, and AVR decreased by 1.12% at 6 months and by 1.73% at 12 months. All the above parameters were statistically significant between groups, but there was no significant change in retinal arteriolar calibers at 6 months. The increased AVR correlated significantly with decreased C-reactive protein (CRP) at 6 months and decreased low-density lipoprotein and CRP at 12 months. Discussion For patients with a low-to-moderate risk of CAD, we found a significant
American Journal of Cardiovascular Drugs – Springer Journals
Published: Feb 22, 2019
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