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Infection of Swiss albino mice with Plasmodium berghei ANKA (PbA), a lethal strain, led to injury of the liver, thymic atrophy and high host mortality. Action of pentoxifylline (PTX), an inhibitor of TNF-α (tumor necrosis factor alpha), was investigated on hepatic necrosis, thymic atrophy, increased percentage of Sub G0/G1 hepatic and thymic populations, parasitemia and survivability of the infected mice host. Our data suggest the importance of PTX in mice survival and curing of liver cirrhosis, without affecting the parasitemic condition of the infected mice. Histomorphological changes were well evident from the appearance of hypertrophied hepatic cells with abundance of pigments. In the thymus no cortico-medullary demarcation was observed with presence of hypertrophied thymocytes. Hyperplasia of hepatic cells in the Sub-G0/G1 stage as revealed by flow cytometric analyses, was suppressed by PTX which is an indication of apoptotic effect of PTX in mice. Mice treated with PTX showed a significant decrease of necrotic areas in liver and thymus, suggesting that PTX treatment controls TNF-α effect, and thus PTX may be used as an adjuvant in the treatment of malaria.
Proceedings of the Zoological Society – Springer Journals
Published: Nov 6, 2012
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