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Effects of N-terminal nociceptin fragment on the anxiety level of American cockroach Periplaneta americana in the “open field” during changes in light intensity

Effects of N-terminal nociceptin fragment on the anxiety level of American cockroach Periplaneta... Injection of N-terminal nociceptin fragment (FN) had an anxiolytic effect on the anxiety level of the cockroach Periplaneta americana during the “open field” test in both red light and varying light. The intensity of horizontal activity (HA) and number of changes in direction (CD) by insects were taken as an indicator of their anxiety level. FN decreased HA in red light to 48% (100 μg/g) and 63% (200 μg/g) with CD of 39% (100 μg/g) relative to control. Tetrapeptide at a dose of 50 μg/g had no significant effect on HA and CD. With the light stimulus increased to 6.0 W, HA and CD reached 230% and 192%, respectively, relative to control. In this case, FN injection inhibited further HA increase in bright light to 37% (100 μg/g) and 50% (200 μg/g). CD also reduced to 39% (100 μg/g) and 68% (200 μg/g) relative to control. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Moscow University Biological Sciences Bulletin Springer Journals

Effects of N-terminal nociceptin fragment on the anxiety level of American cockroach Periplaneta americana in the “open field” during changes in light intensity

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References (21)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Allerton Press, Inc.
Subject
Life Sciences; Biochemistry, general; Cell Biology; Life Sciences, general; Plant Sciences; Zoology
ISSN
0096-3925
eISSN
1934-791X
DOI
10.3103/S0096392515010046
Publisher site
See Article on Publisher Site

Abstract

Injection of N-terminal nociceptin fragment (FN) had an anxiolytic effect on the anxiety level of the cockroach Periplaneta americana during the “open field” test in both red light and varying light. The intensity of horizontal activity (HA) and number of changes in direction (CD) by insects were taken as an indicator of their anxiety level. FN decreased HA in red light to 48% (100 μg/g) and 63% (200 μg/g) with CD of 39% (100 μg/g) relative to control. Tetrapeptide at a dose of 50 μg/g had no significant effect on HA and CD. With the light stimulus increased to 6.0 W, HA and CD reached 230% and 192%, respectively, relative to control. In this case, FN injection inhibited further HA increase in bright light to 37% (100 μg/g) and 50% (200 μg/g). CD also reduced to 39% (100 μg/g) and 68% (200 μg/g) relative to control.

Journal

Moscow University Biological Sciences BulletinSpringer Journals

Published: Apr 7, 2015

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