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Effects of N-Acetylcysteine on the Cardiac Remodeling Biomarkers and Major Adverse Events Following Acute Myocardial Infarction: A Randomized Clinical Trial

Effects of N-Acetylcysteine on the Cardiac Remodeling Biomarkers and Major Adverse Events... Am J Cardiovasc Drugs (2014) 14:51–61 DOI 10.1007/s40256-013-0048-x OR IGINAL RESEARCH ARTIC L E Effects of N-Acetylcysteine on the Cardiac Remodeling Biomarkers and Major Adverse Events Following Acute Myocardial Infarction: A Randomized Clinical Trial • • Azita Hajhossein Talasaz Hossein Khalili • • • Fanak Fahimi Yaser Jenab Mohammad Ali Broumand Mojtaba Salarifar Farzad Darabi Published online: 9 October 2013 Springer International Publishing Switzerland 2013 Abstract Results In patients who received NAC, the serum levels Aims The aims of this study were to evaluate the effects of matrix metalloproteinase (MMP)-9 and MMP-2 after of N-acetylcysteine (NAC) on cardiac remodeling and 72 h were significantly lower than those in the placebo major adverse events following acute myocardial infarction group (p = 0.014 and p = 0.045, respectively). The length (AMI). of hospitalization in patients who received NAC was sig- Methods In a prospective, double-blind, randomized nificantly shorter than that in the placebo group clinical trial, the effect of NAC on the serum levels of (p = 0.024). With respect to MACE, there was a signifi- cardiac biomarkers was compared with that of placebo in cant difference between those who received NAC (14 %) 98 patients with AMI. Also, the patients http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cardiovascular Drugs Springer Journals

Effects of N-Acetylcysteine on the Cardiac Remodeling Biomarkers and Major Adverse Events Following Acute Myocardial Infarction: A Randomized Clinical Trial

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References (54)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer International Publishing Switzerland
Subject
Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
ISSN
1175-3277
eISSN
1179-187X
DOI
10.1007/s40256-013-0048-x
pmid
24105017
Publisher site
See Article on Publisher Site

Abstract

Am J Cardiovasc Drugs (2014) 14:51–61 DOI 10.1007/s40256-013-0048-x OR IGINAL RESEARCH ARTIC L E Effects of N-Acetylcysteine on the Cardiac Remodeling Biomarkers and Major Adverse Events Following Acute Myocardial Infarction: A Randomized Clinical Trial • • Azita Hajhossein Talasaz Hossein Khalili • • • Fanak Fahimi Yaser Jenab Mohammad Ali Broumand Mojtaba Salarifar Farzad Darabi Published online: 9 October 2013 Springer International Publishing Switzerland 2013 Abstract Results In patients who received NAC, the serum levels Aims The aims of this study were to evaluate the effects of matrix metalloproteinase (MMP)-9 and MMP-2 after of N-acetylcysteine (NAC) on cardiac remodeling and 72 h were significantly lower than those in the placebo major adverse events following acute myocardial infarction group (p = 0.014 and p = 0.045, respectively). The length (AMI). of hospitalization in patients who received NAC was sig- Methods In a prospective, double-blind, randomized nificantly shorter than that in the placebo group clinical trial, the effect of NAC on the serum levels of (p = 0.024). With respect to MACE, there was a signifi- cardiac biomarkers was compared with that of placebo in cant difference between those who received NAC (14 %) 98 patients with AMI. Also, the patients

Journal

American Journal of Cardiovascular Drugs – Springer Journals

Published: Oct 9, 2013

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