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Effects of intranasal administration of 5-hydroxytryptamine-modulin endogenous serotonergic modulator on rat behavior

Effects of intranasal administration of 5-hydroxytryptamine-modulin endogenous serotonergic... This article presents the study of the effects of 5-hydroxytryptamine-modulin—a poorly studied endogenous peptide (Leu-Ser-Ala-Leu)—which specifically interacts with 5-HT1B-auto- and heteroreceptors. Data obtained in the experiments on rats suggest prolonged anxiolytic and antidepressive effect of intranasal 5-HT-modulin administration and give evidence to an essential role of endogenous 5-HT-modulin in the regulation of anxiety and depression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Moscow University Biological Sciences Bulletin Springer Journals

Effects of intranasal administration of 5-hydroxytryptamine-modulin endogenous serotonergic modulator on rat behavior

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References (37)

Publisher
Springer Journals
Copyright
Copyright © 2012 by Allerton Press, Inc.
Subject
Life Sciences; Zoology; Life Sciences, general; Biochemistry, general; Plant Sciences; Cell Biology
ISSN
0096-3925
eISSN
1934-791X
DOI
10.3103/S0096392512020083
Publisher site
See Article on Publisher Site

Abstract

This article presents the study of the effects of 5-hydroxytryptamine-modulin—a poorly studied endogenous peptide (Leu-Ser-Ala-Leu)—which specifically interacts with 5-HT1B-auto- and heteroreceptors. Data obtained in the experiments on rats suggest prolonged anxiolytic and antidepressive effect of intranasal 5-HT-modulin administration and give evidence to an essential role of endogenous 5-HT-modulin in the regulation of anxiety and depression.

Journal

Moscow University Biological Sciences BulletinSpringer Journals

Published: Jun 13, 2012

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