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O. Massot, J. Rousselle, M. Fillion, B. Grimaldi, I. Cloëz-Tayarani, A. Fugelli, N. Prudhomme, L. Seguin, B. Rousseau, M. Plantefol, R. Hen, G. Fillion (1996)
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This article presents the study of the effects of 5-hydroxytryptamine-modulin—a poorly studied endogenous peptide (Leu-Ser-Ala-Leu)—which specifically interacts with 5-HT1B-auto- and heteroreceptors. Data obtained in the experiments on rats suggest prolonged anxiolytic and antidepressive effect of intranasal 5-HT-modulin administration and give evidence to an essential role of endogenous 5-HT-modulin in the regulation of anxiety and depression.
Moscow University Biological Sciences Bulletin – Springer Journals
Published: Jun 13, 2012
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