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References (12)
-
G. Kryzhanovskiǐ, A. Shandra, L. Godlevskii, A. Mazarati (1992)
[The antiepileptic system].Uspekhi fiziologicheskikh nauk, 23 3
-
J. Mukawa (1985)
[the cerebellum and epilepsy].No shinkei geka. Neurological surgery, 13 1
-
G. Paxinos, Charles Watson (1983)
The Rat Brain in Stereotaxic Coordinates -
T. Vanaveski, S. Molchanova, D. Pham, Annika Schäfer, Ceren Pajanoja, J. Narvik, Vignesh Srinivasan, M. Urb, Maria Koivisto, E. Vasar, T. Timmusk, R. Minkeviciene, O. Eriksson, M. Lalowski, T. Taira, L. Korhonen, V. Võikar, D. Lindholm (2021)
PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in MiceFrontiers in Molecular Neuroscience, 14
-
H. Hussein, A. Moghimi, A. Roohbakhsh (2019)
Anticonvulsant and ameliorative effects of pioglitazone on cognitive deficits, inflammation and apoptosis in the hippocampus of rat pups exposed to febrile seizureIranian Journal of Basic Medical Sciences, 22
-
LS Godlevsky (2014)
456Acta Neurobiol. Exp. (Wars.), 74
-
L. Godlevsky, T. Muratova, N. Kresyun, G. Luijtelaar, A. Coenen (2014)
Anxiolytic and antidepressive effects of electric stimulation of the paleocerebellar cortex in pentylenetetrazol kindled rats.Acta neurobiologiae experimentalis, 74 4
-
Razieh Mohazab, M. Javadi‐Paydar, B. Delfan, A. Dehpour (2012)
Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in miceEpilepsy Research, 101
-
R. Ciccocioppo, M. Ubaldi (2020)
Nuclear peroxisome proliferator activated receptor-gamma (PPARγ) as a therapeutic target to treat neurodegeneration and dependence elicited by drugs of abuseNeural Regeneration Research, 16
-
D. Abdallah (2010)
Anticonvulsant potential of the peroxisome proliferator-activated receptor gamma agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in miceBrain Research, 1351
-
L. Godlevsky, M. Pervak (2019)
Peroxisomal Proliferator-Activated γ-Receptors: Participation in the Anti-Seizure Effects of Transcranial DC Stimulation of the CerebellumNeurophysiology, 51
-
T. Hung, F. Chu, D. Wu, Sheng-Nan Wu, Chin-Wei Huang (2019)
The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal ExcitotoxicityMolecular Neurobiology, 56
- Publisher
- Springer Journals
- Copyright
- Copyright © Springer Science+Business Media, LLC, part of Springer Nature 2022
- ISSN
- 0090-2977
- eISSN
- 1573-9007
- DOI
- 10.1007/s11062-022-09919-7
- Publisher site
- See Article on Publisher Site
Abstract
In rats with the kindling syndrome induced by i.p. injections of pentylenetetrazole (PTZ; 35 mg/kg daily, for three weeks), the averaged latency of seizures induced by a test injection of PTZ (35 mg/kg) was significantly greater (by 42.2%, P < 0.05 vs. control) after a combination of pioglitazone administration (100 mg/kg, i.p.) and transcranial DC stimulation (tDCS, 300 μA, 10 min, cathode on the skull surface) oriented toward the cerebellar cortex. Also, combined using of tDCS and pioglitazone prevented the occurrence of generalized tonico-clonic seizure attacks in 8 out of 10 rats of the respective group (P < 0.05), reduced the seizure severity by 31.3% on average (P < 0.05), and made shorter ictal discharges (by 45.0%; P < 0.05).
Journal
Neurophysiology – Springer Journals
Published: Mar 1, 2022
Keywords: transcranial DC stimulation (tDCS); cerebellum; pentylenetetrazole-induced seizures; kindling; peroxisomal proliferator-activated γ-receptors (PPARγ)