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Effect of the oral administration of Ephedra Sinica extract on suppression of body weight gains

Effect of the oral administration of Ephedra Sinica extract on suppression of body weight gains Abstract Ephedra Sinica (Ma-hwang, ES) is a medicinal extract used in Oriental Medicine. ES is used clinically to release exterior symptoms, disperse cold, control wheezing, promote urination and reduce edema. Historically, ES have suppressive effect on body weight gains. Using diet-induced obesity C57BL/6 mouse model, anti-obesity effect and cytotoxicity of the longterm oral administration of these herbal extracts were investigated. Herbal extract treated groups were arrested in weight increment only when they were lodged together. Such effects were abolished when they kept individually. ES fed mice behaved very rudely and violently. On the basis of histological studies of liver tissues and also in vitro cytotoxicity tests of the liver and kidney cell lines, no significant toxicity was found by 14 weeks of ES treatments. However, we found significant changes in gene expression profile between ES treated group and SA treated group by micro-array analysis. In case of ES group, up-regulated genes were 113 and down-regulated were 120. Some of lipid metabolism related genes also significantly changed in both treatment groups. In conclusion, ES had effects on increasing the basal metabolic rate by stimulating the sympathetic nervous systems. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioChip Journal Springer Journals

Effect of the oral administration of Ephedra Sinica extract on suppression of body weight gains

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References (3)

Publisher
Springer Journals
Copyright
2010 The Korean BioChip Society and Springer-Verlag Berlin Heidelberg
ISSN
1976-0280
eISSN
2092-7843
DOI
10.1007/s13206-010-4309-3
Publisher site
See Article on Publisher Site

Abstract

Abstract Ephedra Sinica (Ma-hwang, ES) is a medicinal extract used in Oriental Medicine. ES is used clinically to release exterior symptoms, disperse cold, control wheezing, promote urination and reduce edema. Historically, ES have suppressive effect on body weight gains. Using diet-induced obesity C57BL/6 mouse model, anti-obesity effect and cytotoxicity of the longterm oral administration of these herbal extracts were investigated. Herbal extract treated groups were arrested in weight increment only when they were lodged together. Such effects were abolished when they kept individually. ES fed mice behaved very rudely and violently. On the basis of histological studies of liver tissues and also in vitro cytotoxicity tests of the liver and kidney cell lines, no significant toxicity was found by 14 weeks of ES treatments. However, we found significant changes in gene expression profile between ES treated group and SA treated group by micro-array analysis. In case of ES group, up-regulated genes were 113 and down-regulated were 120. Some of lipid metabolism related genes also significantly changed in both treatment groups. In conclusion, ES had effects on increasing the basal metabolic rate by stimulating the sympathetic nervous systems.

Journal

BioChip Journal – Springer Journals

Published: Sep 1, 2010

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