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Changes and correlation analysis of serum leptin and adiponectin expression in patients with gastric and colorectal cancer
ObjectiveTo observe the effect of mild moxibustion on cancer-related fatigue, serum ghrelin and adiponectin in patients undergoing chemotherapy after colorectal cancer surgery.MethodsSeventy patients were divided into a control group and an observation group according to the random number table method, with 35 cases in each group. Patients in both groups were treated with conventional FOLFOX4 chemotherapy regimen. Patients in the control group also received routine treatments such as symptomatic treatment of complications, health education, nutritional support, and exercise intervention. Patients in the observation group received mild moxibustion on the basis of interventions used in the control group. The Piper fatigue scale-revision (PFS-R), Karnofsky performance status (KPS) and spleen and kidney yang deficiency syndrome were scored, and serum ghrelin and adiponectin levels were measured before and after treatment.ResultsAfter treatment, total score of PFS-R in the control group did not change significantly (P>0.05), while in the observation group it was significantly reduced (P<0.05) and lower than that in the control group (P<0.05); KPS scores in both groups were increased (both P<0.05), and it was significantly higher in the observation group than in the control group (P<0.05); total score of spleen and kidney yang deficiency syndrome in the control group did not change significantly (P>0.05), while it was significantly reduced in the observation group (P<0.05) and lower than that in the control group (P<0.05); serum ghrelin and adiponectin levels in the control group had no significant changes (both P>0.05), but the levels were significantly increased in the observation group (both P<0.05) and higher than those in the control group (both P<0.05).ConclusionBased on the routine treatments, mild moxibustion can relieve fatigue, improve quality of life, and improve the symptoms of spleen and kidney yang deficiency in patients undergoing chemotherapy after colorectal cancer surgery, which may be related to the regulation of serum ghrelin and adiponectin levels.
Journal of Acupuncture and Tuina Science – Springer Journals
Published: Jun 25, 2021
Keywords: Moxibustion Therapy; Moxa Stick Moxibustion; Drug Therapy; Drug-related Side Effects and Adverse Reactions; Colorectal Neoplasms; Fatigue; Ghrelin; Adiponectin; 灸法; 艾条灸; 药物疗法; 药物相关的副作用和不良反应; 结肠直肠肿瘤; 疲劳; 胃促生长素; 脂联素; R246.1; A
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